BACKGROUND: To develop and validate a deep learning pipeline using prostate biopsy H&E slides to predict extraprostatic extension (EPE) in prostate cancer (PCa) patients.
Prostate cancer remains a significant public health concern, with a substantial proportion of patients experiencing biochemical recurrence (BCR) after radical prostatectomy (RP). Traditional risk models, such as CAPRA-S, have demonstrated moderate pr...
Parkinson's disease (PD), a progressive neurodegenerative disorder, presents complex motor symptoms and lacks effective disease-modifying treatments. Here we show that integrating artificial intelligence (AI) with optogenetic intervention, termed opt...
Cancer imaging : the official publication of the International Cancer Imaging Society
Aug 21, 2025
BACKGROUND: Accurate preoperative assessment of occult lymph node metastasis (OLNM) plays a crucial role in informing therapeutic decision-making for lung cancer patients. Computed tomography (CT) is the most widely used imaging modality for preopera...
BACKGROUND: Overactive bladder management presents significant challenges, with treatment failures and medication non-adherence posing substantial barriers to patient outcomes. Early prediction of these challenges could enable timely interventions an...
Spinal cord hemangioblastomas are rare, benign, intradural tumors that, despite their nonmalignant histopathology, can lead to substantial neurological morbidity. While disparities in outcomes based on race and socioeconomic status have been well-doc...
The accurate classification of obesity is essential for public health and clinical decision-making. Traditional anthropometric measures such as body mass index (BMI) have limitations in differentiating between fat and lean mass. This study aimed to e...
Diagnostic needle biopsies that miss clinically significant prostate cancer (PCa) often sample benign tissue near hidden cancers. Such benign samples might still display subtle morphological signs of cancer elsewhere in the prostate. This study exami...
Understanding how individual differences influence vulnerability to disease and responses to pharmacological treatments represents one of the main challenges in behavioral neuroscience. Nevertheless, inter-individual variability and sex-specific patt...
Analytical methods : advancing methods and applications
Aug 21, 2025
Dry eye disease (DED) and depression exhibit high comorbidity, yet lipid and purine diagnostic biomarkers for depression-related DED remain unidentified. In this study, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI)...
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