AIMC Topic: Mice, Inbred C57BL

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A deep learning-based approach for unbiased kinematic analysis in CNS injury.

Experimental neurology Sep 5, 2024
Traumatic spinal cord injury (SCI) is a devastating condition that impacts over 300,000 individuals in the US alone. Depending on the severity of the injury, SCI can lead to varying degrees of sensorimotor deficits and paralysis. Despite advances in ...
Locomotion Spinal Cord Injuries Female Animals Biomechanical Phenomena Deep Learning Mice Mice, Inbred C57BL
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Dynamic changes in pyroptosis following spinal cord injury and the identification of crucial molecular signatures through machine learning and single-cell sequencing.

Journal of pharmaceutical and biomedical analysis Aug 26, 2024
The pathological cascade of spinal cord injury (SCI) is highly intricate. The onset of neuroinflammation can exacerbate the extent of damage. Pyroptosis is a form of inflammation-linked programmed cell death (PCD), the inhibition of pyroptosis can pa...
Spinal Cord Injuries Mice Disease Models, Animal Mice, Inbred C57BL Cell Line Machine Learning Neuroinflammatory Diseases Microglia Animals Pyroptosis Male Spinal Cord Single-Cell Analysis
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Attention-based CNN-BiLSTM for sleep state classification of spatiotemporal wide-field calcium imaging data.

Journal of neuroscience methods Aug 14, 2024
BACKGROUND: Wide-field calcium imaging (WFCI) with genetically encoded calcium indicators allows for spatiotemporal recordings of neuronal activity in mice. When applied to the study of sleep, WFCI data are manually scored into the sleep states of wa...
Mice, Inbred C57BL Electroencephalography Calcium Attention Wakefulness Sleep Sleep Stages Animals Male Image Processing, Computer-Assisted Mice Neural Networks, Computer Brain
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Structured adaptive boosting trees for detection of multicellular aggregates in fluorescence intravital microscopy.

Microvascular research Aug 13, 2024
Fluorescence intravital microscopy captures large data sets of dynamic multicellular interactions within various organs such as the lungs, liver, and brain of living subjects. In medical imaging, edge detection is used to accurately identify and deli...
Lung Mice Neutrophils Mice, Inbred C57BL Algorithms Reproducibility of Results Animals Intravital Microscopy Cell Aggregation Predictive Value of Tests Microscopy, Fluorescence Image Interpretation, Computer-Assisted Blood Platelets Machine Learning
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Mechanisms of QingRe HuoXue Formula in atherosclerosis Treatment: An integrated approach using Bioinformatics, Machine Learning, and experimental validation.

International immunopharmacology Aug 12, 2024
BACKGROUND: Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. QingRe HuoXue Formula (QRHXF), a common prescription of traditional Chinese medicine, has a definite effect on the cli...
Humans Machine Learning Mice, Inbred C57BL Drugs, Chinese Herbal Gene Expression Profiling Animals Atherosclerosis Collagen Type I Mice Male Collagen Type I, alpha 1 Chain Computational Biology Molecular Docking Simulation Disease Models, Animal Plaque, Atherosclerotic
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Amino acid metabolomics and machine learning-driven assessment of future liver remnant growth after hepatectomy in livers of various backgrounds.

Journal of pharmaceutical and biomedical analysis Jul 23, 2024
Accurate assessment of future liver remnant growth after partial hepatectomy (PH) in patients with different liver backgrounds is a pressing clinical issue. Amino acid (AA) metabolism plays a crucial role in liver regeneration. In this study, we comb...
Metabolomics Liver Amino Acids Non-alcoholic Fatty Liver Disease Machine Learning Chromatography, High Pressure Liquid Liver Cirrhosis Animals Tandem Mass Spectrometry Disease Models, Animal Male Hepatectomy Mice, Inbred C57BL Mice Liver Regeneration
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Unbiased analysis of spatial learning strategies in a modified Barnes maze using convolutional neural networks.

Scientific reports Jul 10, 2024
Assessment of spatial learning abilities is central to behavioral neuroscience and a useful tool for animal model validation and drug development. However, biases introduced by the apparatus, environment, or experimentalist represent a critical chall...
Alzheimer Disease Behavior, Animal Maze Learning Spatial Learning Mice Disease Models, Animal Mice, Inbred C57BL Neural Networks, Computer Female Animals Male
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Machine-Learning-Guided Peptide Drug Discovery: Development of GLP-1 Receptor Agonists with Improved Drug Properties.

Journal of medicinal chemistry Jul 8, 2024
Peptide-based drug discovery has surged with the development of peptide hormone-derived analogs for the treatment of diabetes and obesity. Machine learning (ML)-enabled quantitative structure-activity relationship (QSAR) approaches have shown great p...
Humans Machine Learning Animals Male Peptides Drug Discovery Mice Mice, Inbred C57BL Obesity Quantitative Structure-Activity Relationship Mice, Obese Glucagon-Like Peptide-1 Receptor Agonists
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A deep-learning-based threshold-free method for automated analysis of rodent behavior in the forced swim test and tail suspension test.

Journal of neuroscience methods Jul 1, 2024
BACKGROUND: The forced swim test (FST) and tail suspension test (TST) are widely used to assess depressive-like behaviors in animals. Immobility time is used as an important parameter in both FST and TST. Traditional methods for analyzing FST and TST...
Animals Male Deep Learning Video Recording Depression Swimming Mice Behavior, Animal Mice, Inbred C57BL Hindlimb Suspension
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Identification of immune-related genes and small-molecule drugs in hypertension-induced left ventricular hypertrophy based on machine learning algorithms and molecular docking.

Frontiers in immunology Jun 27, 2024
BACKGROUND: Left ventricular hypertrophy (LVH) is a common consequence of hypertension and can lead to heart failure. The immune response plays an important role in hypertensive LVH; however, there is no comprehensive method to investigate the mechan...
Hypertension Molecular Docking Simulation Disease Models, Animal Mice, Inbred C57BL Machine Learning Gene Expression Profiling Hypertrophy, Left Ventricular Animals Gene Regulatory Networks Mice Male
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