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Programmable ultrasound-mediated swarms manipulation of bacteria-red blood cell microrobots for tumor-specific thrombosis and robust photothermal therapy.
Trends in biotechnology
Dec 20, 2024
Despite the excellent advantages of biomicrorobots, such as autonomous navigation and targeting actuation, effective penetration and retention to deep lesion sites for effective therapy remains a longstanding challenge. Here, we present dual-engine c...
AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity.
Molecular cancer
Dec 20, 2024
BACKGROUND: Immunogenic cell death (ICD) inducers are often identified in phenotypic screening campaigns by the release or surface exposure of various danger-associated molecular patterns (DAMPs) from malignant cells. This study aimed to streamline t...
Discovery of anticancer peptides from natural and generated sequences using deep learning.
International journal of biological macromolecules
Dec 18, 2024
Anticancer peptides (ACPs) demonstrate significant potential in clinical cancer treatment due to their ability to selectively target and kill cancer cells. In recent years, numerous artificial intelligence (AI) algorithms have been developed. However...
Integrating bioinformatics and machine learning to uncover lncRNA LINC00269 as a key regulator in Parkinson's disease via pyroptosis pathways.
European journal of medical research
Dec 18, 2024
BACKGROUND: Pyroptosis, a specific type of programmed cell death, which has become a significant factor to Parkinson's disease (PD). Concurrently, long non-coding RNAs (lncRNAs) have garnered attention for their regulatory roles in neurodegenerative ...
Machine learning-assisted pattern recognition and imaging of multiplexed cancer cells a porphyrin-embedded dendrimer array.
Journal of materials chemistry. B
Dec 18, 2024
Early cancer detection plays a vital role in improving the survival rate of cancer patients, underscoring the importance of developing cancer detection methods. However, it is a great challenge to achieve simple, rapid, and accurate methods for simul...
Convolutional neural network-assisted Raman spectroscopy for high-precision diagnosis of glioblastoma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Dec 17, 2024
Glioblastoma multiforme (GBM) is the most lethal intracranial tumor with a median survival of approximately 15 months. Due to its highly invasive properties, it is particularly difficult to accurately identify the tumor margins intraoperatively. The ...
Artificial intelligence-driven hydrogel microneedle patches integrating 5-fluorouracil inclusion complex-loaded flexible pegylated liposomes for enhanced non-melanoma skin cancer treatment.
International journal of pharmaceutics
Dec 13, 2024
The current study focused on the development of crosslinked hydrogel microneedle patches (cHMNs) incorporating 5-FU-hydroxypropyl beta-cyclodextrin inclusion complex-loaded flexible PEGylated liposomes (5-FU-HPβCD-loaded FP-LPs) to enhance treatment ...
Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 12, 2024
Endometriosis affects over 190 million women globally, and effective therapies are urgently needed to address the burden of endometriosis on women's health. Using an artificial intelligence (AI)-driven target discovery platform, two unreported therap...
3D electron microscopy for analyzing nanoparticles in the tumor endothelium.
Proceedings of the National Academy of Sciences of the United States of America
Dec 12, 2024
Delivering medical agents to diseased tissues has been challenging, leading researchers to study the in vivo transport process in the body for improving delivery. Many imaging techniques exist for mapping the distribution of medical agent-carrying na...
Cross-disease transcriptomic analysis reveals DOK3 and PAPOLA as therapeutic targets for neuroinflammatory and tumorigenic processes.
Frontiers in immunology
Dec 12, 2024
OBJECTIVE: Subarachnoid hemorrhage (SAH) and tumorigenesis share numerous biological complexities; nevertheless, the specific gene expression profiles and underlying mechanisms remain poorly understood. This study aims to identify differentially expr...
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