Interdisciplinary sciences, computational life sciences
Apr 26, 2021
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are both non-coding RNAs (ncRNAs) and their interactions play important roles in biological processes. Computational methods, such as machine learning and various bioinformatics tools, can predict...
IEEE/ACM transactions on computational biology and bioinformatics
Apr 6, 2021
Increasing evidences revealed that microRNAs (miRNAs) play critical roles in important biological processes. The identification of disease-related miRNAs is critical to understand the molecular mechanisms of human diseases. Most existing computationa...
BACKGROUND: Cumulative evidence from biological experiments has confirmed that miRNAs have significant roles to diagnose and treat complex diseases. However, traditional medical experiments have limitations in time-consuming and high cost so that the...
MicroRNAs (miRNAs) play important roles in post-transcriptional gene regulation and phenotype development. Understanding the regulation of miRNA genes is critical to understand gene regulation. One of the challenges to study miRNA gene regulation is ...
BACKGROUND: microRNAs (miRNAs) have been shown to play essential roles in a wide range of biological processes. Many computational methods have been developed to identify targets of miRNAs. However, the majority of these methods depend on pre-defined...
International journal of radiation oncology, biology, physics
Feb 1, 2021
PURPOSE: Novel actuarial deep learning neural network (ADNN) architectures are proposed for joint prediction of radiation therapy outcomes-radiation pneumonitis (RP) and local control (LC)-in stage III non-small cell lung cancer (NSCLC) patients. Unl...
Arteriosclerosis, thrombosis, and vascular biology
Dec 24, 2020
OBJECTIVE: Our aim was to characterize distinctive clinical antiphospholipid syndrome phenotypes and identify novel microRNA (miRNA)-mRNA-intracellular signaling regulatory networks in monocytes linked to cardiovascular disease. Approach and Results:...
Tumor mutation burden (TMB) is considered to be an independent genetic biomarker that can predict the tumor patient's response to immune checkpoint inhibitors (ICIs). Meanwhile, microRNA (miRNA) plays a key role in regulating the anticancer immune re...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 8, 2020
CNN and LSTM have proven their ability in feature extraction and natural language processing, respectively. So, we tried to use their ability to process the language of RNAs, i.e., predicting sequence of microRNAs using the sequence of mRNA. The idea...
MicroRNAs (miRNAs) are single-stranded RNA molecules that control gene expression in various processes, such as cancers, Alzheimer's disease, and bone metabolic diseases. However, the regulatory roles of miRNAs in osteoporosis have not been systemati...