Whole-slide imaging of histologic sections captures tissue microenvironments and cytologic details in expansive high-resolution images. These images can be mined to extract quantitative features that describe tissues, yielding measurements for hundre...
BACKGROUND: Pathological angiogenesis has been identified in many malignancies as a potential prognostic factor and target for therapy. In most cases, angiogenic analysis is based on the measurement of microvessel density (MVD) detected by immunostai...
IEEE transactions on bio-medical engineering
29993447
UNLABELLED: Vascular ageing is known to be accompanied by arterial stiffening and vascular endothelial dysfunction, and represents an independent factor contributing to the development of cardiovascular disease. The microvascular pulse is affected by...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
30440483
Segmentation of microvessels measured using two-photon microscopy has been studied in the literature with limited success due to uneven intensities associated with optical imaging and shadowing effects. In this work, we address this problem using a c...
IEEE/ACM transactions on computational biology and bioinformatics
31056516
While coronary microvascular dysfunction (CMD) is a major cause of ischemia, it is very challenging to diagnose due to lack of CMD-specific screening measures. CMD has been identified as one of the five priority areas of investigation in a 2014 Natio...
Laboratory investigation; a journal of technical methods and pathology
31201368
Microvascularity is highly correlated with the grading and subtyping of gliomas, making this one of its most important histological features. Accurate quantitative analysis of microvessels is helpful for the development of a targeted therapy for anti...
Hypertension is the leading risk factor of cardiovascular disease and has profound effects on both the structure and function of the microvasculature. Abnormalities of the retinal vasculature may reflect the degree of microvascular damage due to hype...
OBJECTIVES/HYPOTHESIS: Machine learning (ML) is a type of artificial intelligence wherein a computer learns patterns and associations between variables to correctly predict outcomes. The objectives of this study were to 1) use a ML platform to identi...