AIMC Topic: Middle Aged

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Precision identification of endometrial malignancy and precancerous lesions: Development of a machine learning model incorporating multidimensional clinical and imaging parameters.

Medicine
To develop and validate a machine learning (ML) model integrating multidimensional clinical, pathomic, and ultrasound radiomic parameters for precise identification of endometrial malignancy and precancerous lesions, with a focus on addressing the di...

[An objective overview of lifestyle and quality of life in the Spanish population: a quantification of nutri-indices and qualitative health nutritypes].

Nutricion hospitalaria
Introduction: precision nutritional epidemiology studies require the development of initiatives to obtain objective population data that enable the implementation of health strategies. Therefore, the integration of health determinants and risk factor...

T-cell Subset Features and Distributions Evolve across the Colorectal Precancer-Cancer Spectrum.

Cancer immunology research
The immune microenvironment is a crucial component of colorectal carcinoma that has been well characterized, but much less is known about the immune microenvironment of colorectal carcinoma precursors. We hypothesized that T-cell infiltrates might di...

Electronic health record-enhanced signal detection using tree-based scan statistic methods.

American journal of epidemiology
Tree-based scan statistics (TBSS) are data mining methods that screen thousands of hierarchically related health outcomes to detect unsuspected adverse drug effects. TBSS traditionally analyze claims data with outcomes defined via diagnosis codes. TB...

Diagnosing migraine from genome-wide genotype data: a machine learning analysis.

Brain : a journal of neurology
Migraine has an assumed polygenic basis, but the genetic risk variants identified in genome-wide association studies only explain a proportion of the heritability. We aimed to develop machine learning models, capturing non-additive and interactive ef...

Improving accuracy in the estimation of probable dementia in racially and ethnically diverse groups with penalized regression and transfer learning.

American journal of epidemiology
Algorithmic estimations of dementia status are widely used in public health and epidemiologic research, but inadequate algorithm performance across racial/ethnic groups has been a barrier. We present improvements in the accuracy of group-specific "pr...

Heterogeneous cardiovascular effects of sodium-glucose cotransporter 2 inhibitors in type 2 diabetes: a causal forest and target trial emulation study.

European journal of preventive cardiology
AIMS: Evidence is limited as to who benefit the most from sodium-glucose cotransporter 2 inhibitors (SGLT2i), especially among people without elevated cardiovascular disease (CVD) risk. To address this knowledge gap, we investigated the heterogeneity...

Adaptive modelling approach for predicting causes of death: insights from verbal autopsy data in Tanzania.

International health
BACKGROUND: The World Health Organization (WHO) has approved the use of a verbal autopsy (VA), a survey-based approach to generate out-of-hospital causes of death (CoDs). Through this study, an adaptive Bayesian networks machine learning model was de...

Generative Artificial Intelligence-based Surveillance for Avian Influenza Across a Statewide Healthcare System.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Among all 2024 emergency department visits for acute respiratory illness or conjunctivitis across a statewide healthcare system (n = 13 494), generative artificial intelligence-based surveillance with adjunctive human review rapidly and cost-effectiv...

Association between exposure to air pollution and kidney function decline.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
BACKGROUND AND HYPOTHESIS: Chronic kidney disease is a major global health concern, with air pollution increasingly recognized as a key contributor to kidney function decline. This study hypothesizes that exposure to air pollution accelerates kidney ...