AIMC Topic: Middle Aged

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Analysis of Multiple Programmed Cell Death Patterns and Functional Validations of Apoptosis-Associated Genes in Lung Adenocarcinoma.

Annals of surgical oncology
BACKGROUND: Lung adenocarcinoma (LUAD) is marked by its considerable aggressiveness and pronounced heterogeneity. Programmed cell death (PCD) plays a pivotal role in the progression of tumors, their aggressive behavior, resistance to treatment, and r...

Prediction of PD-L1 expression in NSCLC patients using PET/CT radiomics and prognostic modelling for immunotherapy in PD-L1-positive NSCLC patients.

Clinical radiology
AIM: To develop a positron emission tomography/computed tomography (PET/CT)-based radiomics model for predicting programmed cell death ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) patients and estimating progression-free survival...

Development of Multiparametric Prognostic Models for Stereotactic Magnetic Resonance Guided Radiation Therapy of Pancreatic Cancers.

International journal of radiation oncology, biology, physics
PURPOSE: Stereotactic magnetic resonance guided adaptive radiation therapy (SMART) is a new option for local treatment of unresectable pancreatic ductal adenocarcinoma, showing interesting survival and local control (LC) results. Despite this, some p...

A Quantitative Study of Factors Influencing Myasthenia Gravis Telehealth Examination Score.

Muscle & nerve
INTRODUCTION/AIMS: The adoption of telemedicine is generally considered as advantageous for patients and physicians, but there is limited rigorous assessment of examination strengths and limitations. We set out to perform a quantitative assessment of...

Pancreatic Cancer Detection and Differentiation from Chronic Pancreatitis: Potential Biomarkers Identified through a High-Throughput Multiplex Proteomic Assay and Machine Learning-Based Analysis.

Annals of laboratory medicine
BACKGROUND: Pancreatic cancer (PC)-screening methods have limited accuracy despite their high clinical demand. Differential diagnosis of chronic pancreatitis (CP) poses another challenge for PC diagnosis. Therefore, we aimed to identify blood protein...

Real-time surveillance system for patient deterioration: a pragmatic cluster-randomized controlled trial.

Nature medicine
The COmmunicating Narrative Concerns Entered by RNs (CONCERN) early warning system (EWS) uses real-time nursing surveillance documentation patterns in its machine learning algorithm to identify deterioration risk. We conducted a 1-year, multisite, pr...

Integrative Multi-Omics and Routine Blood Analysis Using Deep Learning: Cost-Effective Early Prediction of Chronic Disease Risks.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Chronic noncommunicable diseases (NCDS) are often characterized by gradual onset and slow progression, but the difficulty in early prediction remains a substantial health challenge worldwide. This study aims to explore the interconnectedness of disea...

Automated segmentation of the dorsal root ganglia in MRI.

NeuroImage
The dorsal root ganglion (DRG) contains all primary sensory neurons, but its functional role in somatosensory and pain processing remains unclear. Recently, MR imaging techniques have been developed for objective in vivo observation of the DRG. In pa...

Deep learning-based reconstruction and superresolution for MR-guided thermal ablation of malignant liver lesions.

Cancer imaging : the official publication of the International Cancer Imaging Society
OBJECTIVE: This study evaluates the impact of deep learning-enhanced T1-weighted VIBE sequences (DL-VIBE) on image quality and procedural parameters during MR-guided thermoablation of liver malignancies, compared to standard VIBE (SD-VIBE).

Improved prediction and risk stratification of major adverse cardiovascular events using an explainable machine learning approach combining plasma biomarkers and traditional risk factors.

Cardiovascular diabetology
BACKGROUND: Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality globally. Traditional risk models, primarily based on established risk factors, often lack the precision needed to accurately predict new-onset major advers...