AIMC Topic: Middle Aged

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CT radiomics-based explainable machine learning model for accurate differentiation of malignant and benign endometrial tumors: a two-center study.

Biomedical engineering online
OBJECTIVES: This study aimed to develop and validate a CT radiomics-based explainable machine learning model for precise diagnosing of malignancy and benignity specifically in endometrial cancer (EC) patients.

Development and validation of a multidimensional and interpretable artificial intelligence model to predict gout recurrence in hospitalised patients: a real-world, ambispective multicentre cohort study in China.

BMC medicine
BACKGROUND: Gout is the most common inflammatory arthritis. Recurrent flares are common among hospitalised patients and contribute to substantial clinical and economic burden. However, the accurate prediction of inpatient recurrence remains challengi...

Morphological alterations of peridroplet mitochondria in human liver biopsy.

Scientific reports
Mitochondrial dysfunction and the accumulation of lipid droplets (LD) contribute to the pathogenesis of liver diseases. Mitochondria bound to LD, termed peridroplet mitochondria (PDM), form a subpopulation with distinct functions compared to cytoplas...

Novel morphological indexes for quantitative evaluation of cerebral aneurysm irregularity.

Scientific reports
A cerebral aneurysm may present irregularities associated with rupture risks. However, conventional morphological parameters are limited in evaluating the aneurysm irregularity. Although the mass moment of inertia has been devised for the irregularit...

Development and validation of an interpretable machine learning model for early prediction in patients with diabetes and sepsis.

Scientific reports
We aimed to identify and validate key predictive factors influencing 28-day survival rates in patients with diabetes and sepsis and to develop a predictive model based on these factors to assist clinical decision-making. In this retrospective cohort ...

The Genetic Architecture of the Human Corpus Callosum and its Subregions.

Nature communications
The corpus callosum (CC) is the largest set of white matter fibers connecting the two hemispheres of the brain. In humans, it is essential for coordinating sensorimotor responses and performing associative or executive functions. Identifying which ge...

Prognostic prediction in soft-tissue sarcomas using deep learning and digital pathology of tumor and margin areas.

Scientific reports
The histological FNCLCC grade is the primary prognostic factor in soft-tissue sarcoma (STS) but fails to fully capture high risk patients. This study aimed to develop and validate a deep learning (DL) model to predict metastatic relapse-free survival...

Interpretable radiomics-based machine learning model for differentiating glioblastoma from primary central nervous system lymphoma using contrast-enhanced T1-weighted imaging.

Scientific reports
This study aimed to develop and validate an interpretable radiomics-based machine learning model using contrast-enhanced T1-weighted imaging (CE-T1WI) to differentiate glioblastoma (GB) from primary central nervous system lymphoma (PCNSL), while comp...

Deep learning-based non-invasive differential diagnosis of eyelid basal cell and sebaceous gland carcinomas using photographic images.

International ophthalmology
PURPOSE: Pathological examination, the current gold standard for differentiating eyelid basal cell carcinoma (BCC) and sebaceous gland carcinoma (SGC), is invasive, time-consuming, and often inaccessible in primary care hospitals. Therefore, a non-in...