AIMC Topic: Mitophagy

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An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates.

Nature communications Jun 4, 2025
Mitophagy, the selective autophagic elimination of mitochondria, is essential for maintaining mitochondrial quality and cell homeostasis. Impairment of mitophagy flux, a process involving multiple sequential intermediates, is implicated in the onset ...
Autophagosomes Mice Humans Artificial Intelligence Lysosomes Animals Mitochondria Amyloid beta-Peptides Alzheimer Disease Microscopy, Fluorescence HeLa Cells Mitophagy
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Identification of mitophagy-related biomarkers in severe acute pancreatitis: integration of WGCNA, machine learning algorithms and scRNA-seq.

Frontiers in immunology May 28, 2025
BACKGROUND: Mitophagy is a highly conserved cellular process in eukaryotic cells that selectively clears dysfunctional or damaged mitochondria through autophagy mechanisms to maintain mitochondrial homeostasis. However, the role of mitophagy in the p...
Biomarkers Animals Gene Expression Profiling Single-Cell Analysis Humans Machine Learning Algorithms Computational Biology Disease Models, Animal Pancreatitis Mitophagy RNA-Seq Gene Regulatory Networks Single-Cell Gene Expression Analysis Mice
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The role and machine learning analysis of mitochondrial autophagy-related gene expression in lung adenocarcinoma.

Frontiers in immunology Apr 17, 2025
OBJECTIVE: Lung adenocarcinoma (LUAD) continues to be a primary cause of cancer-related mortality globally, highlighting the urgent need for novel insights finto its molecular mechanisms. This study aims to investigate the relationship between gene e...
Adenocarcinoma of Lung Mitophagy Gene Expression Regulation, Neoplastic Databases, Genetic Autophagy Mitochondria Gene Regulatory Networks Lung Neoplasms Humans Computational Biology Machine Learning Biomarkers, Tumor Gene Expression Profiling
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Integrating single-cell sequencing and machine learning to uncover the role of mitophagy in subtyping and prognosis of esophageal cancer.

Apoptosis : an international journal on programmed cell death Feb 13, 2025
Globally, esophageal cancer stands as a prominent contributor to cancer-related fatalities, distinguished by its poor prognosis. Mitophagy has a significant impact on the process of cancer progression. This study investigated the prognostic significa...
Prognosis Female Tumor Microenvironment Biomarkers, Tumor Humans Machine Learning Male Mitophagy Single-Cell Analysis Gene Expression Regulation, Neoplastic Esophageal Neoplasms
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The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning.

Immunologic research Jan 11, 2025
Mitophagy, the selective degradation of mitochondria by autophagy, plays a crucial role in cancer progression and therapy response. This study aims to elucidate the role of mitophagy-related genes (MRGs) in cutaneous melanoma (CM) through single-cell...
Gene Regulatory Networks Immunotherapy Sequence Analysis, RNA Gene Expression Regulation, Neoplastic Biomarkers, Tumor Gene Expression Profiling Transcriptome Single-Cell Analysis Melanoma, Cutaneous Malignant Mitophagy Humans Machine Learning Prognosis Melanoma Skin Neoplasms Tumor Microenvironment
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Impact of Mitophagy-Related Genes on the Diagnosis and Development of Esophageal Squamous Cell Carcinoma via Single-Cell RNA-seq Analysis and Machine Learning Algorithms.

Journal of microbiology and biotechnology Sep 23, 2024
As a treatment for esophageal squamous cell carcinoma (ESCC), which is common and fatal, mitophagy is a conserved cellular mechanism that selectively removes damaged mitochondria and is crucial for cellular homeostasis. While tumor development and re...
Gene Expression Regulation, Neoplastic Cell Proliferation Cell Movement Esophageal Neoplasms Mitochondria Esophageal Squamous Cell Carcinoma Apoptosis Regulatory Proteins Mitochondrial Proteins Cell Line, Tumor Single-Cell Analysis Humans RNA-Seq Machine Learning Single-Cell Gene Expression Analysis Algorithms Prognosis Biomarkers, Tumor Mitophagy Transcriptome
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Identification of mitophagy-related genes and analysis of immune infiltration in the astrocytes based on machine learning in the pathogenesis of major depressive disorder.

Journal of affective disorders Sep 14, 2024
BACKGROUNDS: Major depressive disorder (MDD) is a pervasive mental and mood disorder with complicated and heterogeneous etiology. Mitophagy, a selective autophagy of cells, specifically eliminates dysfunctional mitochondria. The mitochondria dysfunct...
MicroRNAs Astrocytes Mitochondria Mitophagy Humans Gene Expression Profiling Machine Learning Gene Regulatory Networks Depressive Disorder, Major Computational Biology Transcription Factors
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Multi omics analysis of mitophagy subtypes and integration of machine learning for predicting immunotherapy responses in head and neck squamous cell carcinoma.

Aging Jun 21, 2024
Mitophagy serves as a critical mechanism for tumor cell death, significantly impacting the progression of tumors and their treatment approaches. There are significant challenges in treating patients with head and neck squamous cell carcinoma, undersc...
Prognosis Immunotherapy Multiomics Gene Expression Regulation, Neoplastic Mitophagy Humans Machine Learning Squamous Cell Carcinoma of Head and Neck Head and Neck Neoplasms DNA Copy Number Variations Mutation
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From jeopardy champion to drug discovery; semantic similarity artificial intelligence.

Autophagy May 14, 2023
We have employed artificial intelligence to streamline the small molecule drug screening pipeline and identified the cholesterol-reducing compound probucol in the process. Probucol augmented mitophagy and prevented loss of dopaminergic neurons in fli...
Semantics Humans Mitophagy Artificial Intelligence Animals Drug Discovery
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The NAD-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications.

Mechanisms of ageing and development Dec 5, 2019
Nicotinamide adenine dinucleotide (NAD) is an important natural molecule involved in fundamental biological processes, including the TCA cycle, OXPHOS, β-oxidation, and is a co-factor for proteins promoting healthy longevity. NAD depletion is associa...
NAD Healthy Aging Mitochondria Mitophagy Alzheimer Disease Humans Organelle Biogenesis Homeostasis Artificial Intelligence Longevity Drug Discovery
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