Hypertrophic cardiomyopathy (HCM), a genetic heart disease defined by unexplained cardiac wall thickening, is a leading cause of sudden death worldwide. However, the three-dimensional organization of cardiac tissue underlying left ventricular hypertr...
Biomedical physics & engineering express
Dec 22, 2025
Accurate myocardial segmentation in myocardial contrast echocardiography (MCE) images remains challenging due to the scarcity of publicly available labeled datasets and the pervasive presence of speckle noise.Currently, echocardiographers must manual...
Cardiovascular disease is the leading global cause of death, underscoring the need for accurate assessment of myocardial injury. The current gold standard, bright-blood late gadolinium enhanced MRI, suffers from poor contrast at the blood-scar interf...
Late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging plays a crucial role in assessing myocardial scar tissues, aiding in the diagnosis and prognosis of cardiovascular diseases. However, accurately classifying scar tissue severity...
Understanding the process of fibrotic scarring of the myocardium is critical for the diagnosis and risk stratification of life-threatening cardiac dysfunction. Complex changes in structure, composition, and conductivity occurring at different stages ...
Machine learning (ML) classification of myocardial scarring in cardiac MRI is often hindered by limited explainability, particularly with convolutional neural networks (CNNs). To address this, we developed One Match (OM), an algorithm that builds on ...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Jun 3, 2025
Myocardial fibrosis, a hallmark of heart failure (HF), contributes to disease progression and mortality by impairing cardiac function. Despite the identification of potential anti-fibrotic molecules, there is a lack of effective pharmacological inter...
Although iron is an essential element for vital body functions, iron overload (IO) is accompanied by significant cellular damage due to its accumulation within organs. Thus, early diagnosis and accurate identification of the affected organs are criti...
BACKGROUND: Cardiac magnetic resonance imaging (CMR) provides critical pathological information, such as scars and edema, which are vital for diagnosing myocardial infarction (MI). However, due to the limited pathological information in single-sequen...
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