AIMC Topic: Non-alcoholic Fatty Liver Disease
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Deep Learning Reveals Liver MRI Features Associated With PNPLA3 I148M in Steatotic Liver Disease.
Liver international : official journal of the International Association for the Study of the Liver
Jul 1, 2025
BACKGROUND: Steatotic liver disease (SLD) is the most common liver disease worldwide, affecting 30% of the global population. It is strongly associated with the interplay of genetic and lifestyle-related risk factors. The genetic variant accounting f...
The machine learning prediction model of non-alcoholic fatty liver; the role of hydrogen and methane breath tests.
Journal of breath research
Jun 13, 2025
Nonalcoholic fatty liver disease (NAFLD) is now the leading cause of global chronic liver disease, affecting approximately 32.4% of the population in various regions and imposing healthcare and economic burdens. The gold standard for the diagnosis of...
Identifying shared hub genes in LIRI and MASLD through bioinformatics analysis and machine learning.
Scientific reports
May 27, 2025
Patients with metabolic dysfunction-associated steatotic liver disease (MASLD) are more susceptible to liver ischemia-reperfusion injury (LIRI), complicating liver surgery outcomes. This study aimed to uncover shared hub genes and mechanisms linking ...
Machine learning for predicting all-cause mortality of metabolic dysfunction-associated fatty liver disease: a longitudinal study based on NHANES.
BMC gastroenterology
May 15, 2025
BACKGROUND: The mortality burden of metabolic dysfunction-associated fatty liver disease (MAFLD) is rising, making it crucial to predict mortality and identify the factors influencing it. While advanced machine learning algorithms are gaining recogni...
Identification of potential metabolic biomarkers and immune cell infiltration for metabolic associated steatohepatitis by bioinformatics analysis and machine learning.
Scientific reports
May 13, 2025
BACKGROUND: Metabolic associated steatohepatitis (MASH) represents a severe subtype of metabolic associated fatty liver disease (MASLD), with an increased risk of progression to cirrhosis and hepatocellular carcinoma. The nomenclature shift from nona...
Multiple machine learning algorithms identify 13 types of cell death-critical genes in large and multiple non-alcoholic steatohepatitis cohorts.
Lipids in health and disease
May 8, 2025
BACKGROUND: Dysregulated programmed cell death pathways mechanistically contribute to hepatic inflammation and fibrogenesis in non-alcoholic steatohepatitis (NASH). Identification of cell death genes may offer insights into diagnostic and therapeutic...
Mitochondrial mt12361A>G increased risk of metabolic dysfunction-associated steatotic liver disease among non-diabetes.
World journal of gastroenterology
Mar 14, 2025
BACKGROUND: Insulin resistance, lipotoxicity, and mitochondrial dysfunction contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). Mitochondrial dysfunction impairs oxidative phosphorylation and increases ...
Machine learning-based models for advanced fibrosis in non-alcoholic steatohepatitis patients: A cohort study.
World journal of gastroenterology
Mar 7, 2025
BACKGROUND: The global prevalence of non-alcoholic steatohepatitis (NASH) and its associated risk of adverse outcomes, particularly in patients with advanced liver fibrosis, underscores the importance of early and accurate diagnosis.
The impact of multipollutant exposure on hepatic steatosis: a machine learning-based investigation into multipollutant synergistic effects.
Frontiers in public health
Jan 1, 2025
INTRODUCTION: This study examines the synergistic effects of multi-pollutant exposure on hepatic lipid accumulation in non-alcoholic fatty liver disease (NAFLD) through the application of an explainable machine learning framework. This approach addre...
Identification of regulatory cell death-related genes during MASH progression using bioinformatics analysis and machine learning strategies.
Frontiers in immunology
Jan 1, 2025
BACKGROUND: Metabolic dysfunction-associated steatohepatitis (MASH) is becoming increasingly prevalent. Regulated cell death (RCD) has emerged as a significant disease phenotype and may act as a marker for liver fibrosis. The present study aimed to i...
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