AIMC Topic: Pancreatic Neoplasms
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Serum peptide biomarkers by MALDI-TOF MS coupled with machine learning for diagnosis and classification of hepato-pancreato-biliary cancers.
Scientific reports
Aug 9, 2025
This study aimed to investigate the potential of peptide mass fingerprints (PMFs) of the serum peptidome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), in combination with machine learning algorithm...
Human multiethnic radiogenomics reveals low-abundancy microRNA signature in plasma-derived extracellular vesicles for early diagnosis and molecular subtyping of pancreatic cancer.
eLife
Aug 8, 2025
Pancreatic cancer (PC) is a highly aggressive malignancy in humans, where early diagnosis significantly improves patient outcomes. However, effective methods for accurate and early detection remain limited. In this multiethnic study involving human s...
The development of a multimodal prediction model based on CT and MRI for the prognosis of pancreatic cancer.
BMC gastroenterology
Aug 6, 2025
PURPOSE: To develop and validate a hybrid radiomics model to predict the overall survival in pancreatic cancer patients and identify risk factors that affect patient prognosis.
Effectiveness of Radiomics-Based Machine Learning Models in Differentiating Pancreatitis and Pancreatic Ductal Adenocarcinoma: Systematic Review and Meta-Analysis.
Journal of medical Internet research
Jul 31, 2025
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) and mass-forming pancreatitis (MFP) share similar clinical, laboratory, and imaging features, making accurate diagnosis challenging. Nevertheless, PDAC is highly malignant with a poor prognosis, whe...
SPP1 + macrophages facilitate pancreatic cancer progression via ITGB6-mediated interactions: evidence from integrated multi-omics analysis and experimental validation.
Immunologic research
Jul 28, 2025
Basement membranes (BMs) and tumor-associated macrophages (TAMs) are crucial stromal components in pancreatic cancer (PC), critically influencing disease progression. Bulk and single-cell RNA-seq (scRNA-seq) data were acquired from publicly available...
Interpretable machine learning-guided single-cell mapping deciphers multi-lineage pancreatic dysregulation in type 2 diabetes.
Cardiovascular diabetology
Jul 24, 2025
BACKGROUND: Pancreatic cellular heterogeneity is fundamental to systemic metabolic regulation, yet its pathological remodeling in diabetes remains poorly characterized.
Early neoplastic lesions of the pancreas: initiation, progression, and opportunities for precancer interception.
The Journal of clinical investigation
Jul 15, 2025
Pancreatic ductal adenocarcinoma (PDAC) is known to progress from one of two main precursor lesions: pancreatic intraepithelial neoplasia (PanIN) or intraductal papillary mucinous neoplasm (IPMN). The poor survival rates for patients with PDAC, even ...
Machine-Learning-Driven Discovery of -Phenylbenzenesulfonamides as a Novel Chemotype for Lactate Dehydrogenase A Inhibition with Anti-Pancreatic Cancer Activity.
Journal of medicinal chemistry
Jul 11, 2025
Lactate dehydrogenase A (LDHA) is a promising target for cancer therapy due to its crucial role in aerobic glycolysis. Despite extensive efforts, the structural diversity of LDHA inhibitors remains limited. Here, we utilized machine learning techniqu...
Multi-omics integration and machine learning uncover molecular basal-like subtype of pancreatic cancer and implicate A2ML1 in promoting tumor epithelial-mesenchymal transition.
Journal of translational medicine
Jul 4, 2025
BACKGROUND: Pancreatic cancer (PC) represents a highly heterogeneous malignancy with poor prognosis, where precise molecular subtyping facilitates comprehensive understanding of disease progression.
Unveiling the mechanisms and promising molecular targets of curcumin in pancreatic cancer through multi-dimensional data.
Scientific reports
Jul 1, 2025
Pancreatic cancer (PC) is a highly aggressive and fatal malignancy, primarily affecting older males. Curcumin, a potential anti-cancer agent, has been shown to regulate key molecules in cancer progression, but its specific mechanisms in PC remain unc...
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