AIMC Topic: Pancreatic Neoplasms
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Label-free single-cell phenotyping to determine tumor cell heterogeneity in pancreatic cancer in real time.
JCI insight
Jul 8, 2025
Resistance to chemotherapy of pancreatic ductal adenocarcinoma (PDAC) is largely driven by intratumoral heterogeneity (ITH) due to tumor cell plasticity and clonal diversity. To develop alternative strategies to overcome this defined mechanism of res...
Medical management of pancreatic cancer: from personalization to broadening treatment strategies.
Cancer treatment reviews
Jul 1, 2025
Pancreatic ductal adenocarcinoma (PDAC) is one of the most heterogeneous and deadly cancers. This review examines recently implemented strategies to integrate predictive tools and targeted therapies to improve treatments personalization and patient o...
Integrating AI/ML and multi-omics approaches to investigate the role of TNFRSF10A/TRAILR1 and its potential targets in pancreatic cancer.
Computers in biology and medicine
Jul 1, 2025
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival of under 10 % despite current therapies. Aggressive tumor biology, a desmoplastic stroma that limits drug delivery and immune cell infiltra...
Advances in pancreatic cancer diagnosis: from DNA methylation to AI-assisted imaging.
Expert review of molecular diagnostics
Jul 1, 2025
INTRODUCTION: Pancreatic Cancer (PC) is a highly aggressive tumor that is mainly diagnosed at later stages. Various imaging technologies, such as CT, MRI, and EUS, possess limitations in early PC diagnosis. Therefore, this review article explores the...
Computationally Enabled Polychromatic Polarized Imaging Enables Mapping of Matrix Architectures that Promote Pancreatic Ductal Adenocarcinoma Dissemination.
The American journal of pathology
Jul 1, 2025
Pancreatic ductal adenocarcinoma (PDA) is a highly metastatic and lethal disease. In PDA, extracellular matrix (ECM) architectures, known as tumor-associated collagen signatures (TACSs), regulate invasion and metastatic spread in both early dissemina...
Development and validation of a machine learning prognostic model based on an epigenomic signature in patients with pancreatic ductal adenocarcinoma.
International journal of medical informatics
Jul 1, 2025
BACKGROUND: In Pancreatic Ductal Adenocarcinoma (PDAC), current prognostic scores are unable to fully capture the biological heterogeneity of the disease. While some approaches investigating the role of multi-omics in PDAC are emerging, the analysis ...
From classical approaches to artificial intelligence, old and new tools for PDAC risk stratification and prediction.
Seminars in cancer biology
Jul 1, 2025
Pancreatic ductal adenocarcinoma (PDAC) is recognized as one of the most lethal malignancies, characterized by late-stage diagnosis and limited therapeutic options. Risk stratification has traditionally been performed using epidemiological studies an...
LUNETR: Language-Infused UNETR for precise pancreatic tumor segmentation in 3D medical image.
Neural networks : the official journal of the International Neural Network Society
Jul 1, 2025
The identification of early micro-lesions and adjacent blood vessels in CT scans plays a pivotal role in the clinical diagnosis of pancreatic cancer, considering its aggressive nature and high fatality rate. Despite the widespread application of deep...
Pathway Enrichment-Based Unsupervised Learning Identifies Novel Subtypes of Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma.
Interdisciplinary sciences, computational life sciences
Jun 1, 2025
Existing single-cell clustering methods are based on gene expressions that are susceptible to dropout events in single-cell RNA sequencing (scRNA-seq) data. To overcome this limitation, we proposed a pathway-based clustering method for single cells (...
Sociodemographic Profile of People with Diagnosed Pancreatic Cancer in the UK: Retrospective Sentinel Network Cohort Study.
Studies in health technology and informatics
May 15, 2025
Pancreatic cancer is a devasting disease which is an increasing cause of cancer mortality. The aim of this study was to characterise, using descriptive statistics, the sociodemographic, risk and clinical characteristics of who develops pancreatic can...
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