AIMC Topic: Piperidines
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Quantitative structure-retention relationship model for the determination of naratriptan hydrochloride and its impurities based on artificial neural networks coupled with genetic algorithm.
Talanta
Nov 20, 2016
Mathematical modeling of Quantitative Structure - Property Relationships met great interest in fields of in silico drug design and more recently, pharmaceutical analysis. In our approach we proposed automated method of creation Quantitative Structure...
Pharmacokinetics, Safety, and Tolerability of Once-Daily Intranasal Fluticasone Furoate and Levocabastine Administered Alone or Simultaneously as fluticasone Furoate/Levocabastine Fixed-Dose Combination.
Clinical pharmacology in drug development
Dec 4, 2015
PURPOSE: The purpose of this study was to investigate potential systemic pharmacokinetic interactions between intranasal fluticasone furoate (FF) and levocabastine (LEVO) when delivered simultaneously via a metered atomizing spray pump.
Comparison of emergence after deep extubation using desflurane or desflurane with remifentanil in patients undergoing general anesthesia: a randomized trial.
Journal of clinical anesthesia
Nov 11, 2015
STUDY OBJECTIVE: To compare recovery times and respiratory complications during emergence after deep extubation using either desflurane alone or a lower concentration of desflurane with remifentanil.
Desflurane
Pulmonary Alveoli
Respiration Disorders
Piperidines
Airway Extubation
Anesthesia Recovery Period
Anesthetics, Inhalation
Anesthesia, General
Double-Blind Method
Isoflurane
Anesthetics, Intravenous
Humans
Prospective Studies
Female
Young Adult
Middle Aged
Postoperative Complications
Remifentanil
Adult
Male
Preoperative dexmedetomidine attenuates hemodynamic responses to hydrodissection in patients undergoing robotic thyroidectomy.
Journal of anesthesia
Sep 28, 2014
PURPOSE: Percutaneous tunneling (hydrodissection) in the neck and anterior chest in patients undergoing robotic thyroidectomy leads to significant hemodynamic responses such as increases in blood pressure and heart rate. We evaluated whether a single...
Predicting the risk of ibrutinib in combination with R-ICE in patients with relapsed or refractory DLBCL using explainable machine learning algorithms.
Clinical and experimental medicine
May 26, 2025
Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) poses significant therapeutic challenges due to heterogeneous patient outcomes. This study aimed to evaluate the efficacy of the ibrutinib plus R-ICE regimen and to leverage explainable mac...
Explainable machine learning prediction of edema adverse events in patients treated with tepotinib.
Clinical and translational science
Sep 1, 2024
Tepotinib is approved for the treatment of patients with non-small-cell lung cancer harboring MET exon 14 skipping alterations. While edema is the most prevalent adverse event (AE) and a known class effect of MET inhibitors including tepotinib, there...
Long short-term memory neural network for directly inverse design of nanofin metasurface.
Optics letters
Jul 1, 2022
In this Letter, the neural network long short-term memory (LSTM) is used to quickly and accurately predict the polarization sensitivity of a nanofin metasurface. In the forward prediction, we construct a deep neural network (DNN) with the same struct...
Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/ bile salt bilosomes.
Pakistan journal of pharmaceutical sciences
Sep 1, 2020
Although ebastine (EBT) can impede histamine-induced skin allergic reaction and persuade long acting selective H1 receptor antagonistic effects but its poor water solubility circumscribed its clinical application. The main objective of this research ...
Comparative study between UHPLC-UV and UPLC-MS/MS methods for determination of alogliptin and metformin in their pharmaceutical combination.
Die Pharmazie
Feb 1, 2017
A new UPLC-MS/MS method (method A), for simultaneous determination of alogliptin (ALN) and metformin (MET) in their recently approved pharmaceutical combination Kazano® tablets, was developed and compared to a new UHPLC-UV method (method B). Concerni...
[The influence of the sedation based on remifentanil analgesia on the occurrence of delirium in critically ill patients].
Zhonghua wei zhong bing ji jiu yi xue
Oct 1, 2015
OBJECTIVE: To investigate the influence of the midazolam sedation based on remifentanil analgesia on the occurrence of delirium in critically ill patients in intensive care unit (ICU).
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