AIMC Topic: Polyethylene Glycols
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Growth Factor Delivery for the Repair of a Critical Size Tibia Defect Using an Acellular, Biodegradable Polyethylene Glycol-Albumin Hydrogel Implant.
ACS biomaterials science & engineering
Nov 5, 2019
Growth factor delivery using acellular matrices presents a promising alternative to current treatment options for bone repair in critical-size injuries. However, supra-physiological doses of the factors can introduce safety concerns that must be alle...
Application of artificial neural networks for Process Analytical Technology-based dissolution testing.
International journal of pharmaceutics
Jun 25, 2019
This work proposes the application of artificial neural networks (ANN) to non-destructively predict the in vitro dissolution of pharmaceutical tablets from Process Analytical Technology (PAT) data. An extended release tablet formulation was studied, ...
A highly effective, recyclable, and novel host-guest nanocomposite for Triclosan removal: A comprehensive modeling and optimization-based adsorption study.
Journal of colloid and interface science
May 3, 2019
In this research paper, response surface methodology (RSM), generalized regression neural network (GRNN), and Adaptive Neuro-Fuzzy Inference System (ANFIS) were employed to develop prediction models for Triclosan (TCS) removal by a novel inclusion co...
Hypoxia-responsive micelles self-assembled from amphiphilic block copolymers for the controlled release of anticancer drugs.
Journal of materials chemistry. B
Dec 12, 2018
Amphiphilic block copolymers poly(ethylene glycol)-block-poly(methacrylic acid-co-2-nitroimidazole methacrylate) (PEG-b-P(MAA-co-NIMA)) were synthesized by the combination of atom transfer radical polymerization (ATRP), hydrolysis and EDC reactions. ...
Artificial neural networks (ANNs) and partial least squares (PLS) regression in the quantitative analysis of cocrystal formulations by Raman and ATR-FTIR spectroscopy.
Journal of pharmaceutical and biomedical analysis
Jun 4, 2018
The present work describes the development of an efficient, fast and accurate method for the quantification of polymer-based cocrystal formulations. Specifically, the content of carbamazepine-nicotinamide (CBZ/NIC) and ibuprofen-nicotinamide (IBU/NIC...
Neural Networks, Computer
Least-Squares Analysis
Polyethylene Glycols
Drug Compounding
Absorption, Physicochemical
Machine Learning
Spectrum Analysis, Raman
Drug Combinations
Spectroscopy, Fourier Transform Infrared
Calibration
Polyvinyls
Crystallization
Ibuprofen
Chemistry, Pharmaceutical
Niacinamide
Carbamazepine
A method for optical imaging and monitoring of the excretion of fluorescent nanocomposites from the body using artificial neural networks.
Nanomedicine : nanotechnology, biology, and medicine
Apr 12, 2018
In this study, a new approach to the implementation of optical imaging of fluorescent nanoparticles in a biological medium using artificial neural networks is proposed. The studies were carried out using new synthesized nanocomposites - nanometer gra...
Aminolated and Thiolated PEG-Covered Gold Nanoparticles with High Stability and Antiaggregation for Lateral Flow Detection of Bisphenol A.
Small (Weinheim an der Bergstrasse, Germany)
Dec 27, 2017
The few lateral flow assays (LFAs) established for detecting the endocrine disrupting chemical bisphenol A (BPA) have employed citrate-stabilized gold nanoparticles (GNPs), which have inevitable limitations and instability issues. To address these li...
Toltrazuril mixed nanomicelle delivery system based on sodium deoxycholate-Brij C20 polyethylene ether-triton x100: Characterization, solubility, and bioavailability study.
Colloids and surfaces. B, Biointerfaces
Dec 16, 2017
Toltrazuril (Tol) is a broad-spectrum anticoccidiosis drug that is widely used in the prevention and treatment of coccidiosis infection in poultry and mammals. However, the drug has poor aqueous solubility (25 °C, 0.41 μg/mL), and its dose escalation...
Salinomycin-loaded lipid-polymer nanoparticles with anti-CD20 aptamers selectively suppress human CD20+ melanoma stem cells.
Acta pharmacologica Sinica
Dec 14, 2017
Melanoma is the deadliest type of skin cancer. CD20+ melanoma stem cells (CSCs) are pivotal for metastasis and initiation of melanoma. Therefore, selective elimination of CD20+ melanoma CSCs represents an effective treatment to eradicate melanoma. Sa...
Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.
Journal of colloid and interface science
Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Prodrugs
HeLa Cells
Hydrophobic and Hydrophilic Interactions
Polypropylenes
Surface Properties
Ibuprofen
Anhydrides
Fumarates
Hydrolysis
Solubility
Drug Liberation
Micelles
Rabbits
Hydrogen-Ion Concentration
Polyethylene Glycols
Humans
Animals
Nanoparticles
Cell Line
Cell Survival
Drug Carriers
Anti-Inflammatory Agents, Non-Steroidal
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