AIMC Topic: Polymorphism, Genetic

Clear Filters Showing 21 to 30 of 30 articles

Functional connectivity correlates of response inhibition impairment in anorexia nervosa.

Psychiatry research. Neuroimaging Dec 2, 2015
Anorexia nervosa (AN) is a disorder characterized by high levels of cognitive control and behavioral perseveration. The present study aims at exploring inhibitory control abilities and their functional connectivity correlates in patients with AN. Inh...
Executive Function Serotonin Plasma Membrane Transport Proteins Rest Polymorphism, Genetic Anorexia Nervosa Catechol O-Methyltransferase Brain Magnetic Resonance Imaging Female Attention Adult Psychomotor Performance Middle Aged Case-Control Studies Humans Body Mass Index Neural Networks, Computer Phenotype
View on PubMed DOI

Hierarchical boosting: a machine-learning framework to detect and classify hard selective sweeps in human populations.

Bioinformatics (Oxford, England) Aug 26, 2015
MOTIVATION: Detecting positive selection in genomic regions is a recurrent topic in natural population genetic studies. However, there is little consistency among the regions detected in several genome-wide scans using different tests and/or populati...
Humans Genetics, Population Machine Learning Genomics Polymorphism, Genetic Selection, Genetic Demography
View on PubMed DOI

Predicting Methylphenidate Response in ADHD Using Machine Learning Approaches.

The international journal of neuropsychopharmacology May 10, 2015
BACKGROUND: There are no objective, biological markers that can robustly predict methylphenidate response in attention deficit hyperactivity disorder. This study aimed to examine whether applying machine learning approaches to pretreatment demographi...
Central Nervous System Stimulants Attention Deficit Disorder with Hyperactivity Methylphenidate Drug Therapy, Computer-Assisted Stroop Test Norepinephrine Plasma Membrane Transport Proteins Receptors, Adrenergic, alpha-2 Cotinine Body Weight Rest Polymorphism, Genetic Support Vector Machine Prognosis Age Factors Humans Female Male Magnetic Resonance Imaging Brain Child Lead Treatment Outcome
View on PubMed DOI

Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

European journal of drug metabolism and pharmacokinetics Dec 1, 2020
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorph...
Predictive Value of Tests Area Under Curve Asian People Cross-Over Studies Healthy Volunteers Male Middle Aged Adolescent Polymorphism, Single Nucleotide Female Iron Chelating Agents Young Adult Glucuronosyltransferase Adult Multidrug Resistance-Associated Proteins Humans Half-Life Multidrug Resistance-Associated Protein 2 Neural Networks, Computer Drug Compounding Cytochrome P-450 CYP1A1 Polymorphism, Genetic Deferasirox
View on PubMed DOI

Functional interpretation of genetic variants using deep learning predicts impact on chromatin accessibility and histone modification.

Nucleic acids research Nov 18, 2019
Identifying functional variants underlying disease risk and adoption of personalized medicine are currently limited by the challenge of interpreting the functional consequences of genetic variants. Predicting the functional effects of disease-associa...
Sequence Analysis, DNA Humans Polymorphism, Genetic Deep Learning Chromatin Assembly and Disassembly Genome-Wide Association Study Histone Code Epigenesis, Genetic
View on PubMed DOI

Interaction Effects of Gene Polymorphisms and Obesity on Nonalcoholic Fatty Liver Disease.

Biomedical and environmental sciences : BES Oct 1, 2019
Aged, 80 and over Male Middle Aged China Models, Theoretical Humans Female Aged Obesity Non-alcoholic Fatty Liver Disease Polymorphism, Genetic Multifactor Dimensionality Reduction
View on PubMed DOI

Using Machine Learning and Natural Language Processing to Review and Classify the Medical Literature on Cancer Susceptibility Genes.

JCO clinical cancer informatics Sep 1, 2019
PURPOSE: The medical literature relevant to germline genetics is growing exponentially. Clinicians need tools that help to monitor and prioritize the literature to understand the clinical implications of pathogenic genetic variants. We developed and ...
Natural Language Processing Polymorphism, Genetic Knowledge Discovery Oncogenes Prevalence ROC Curve Genetic Predisposition to Disease Support Vector Machine Medicine in Literature Machine Learning Reproducibility of Results Neoplasms Humans
View on PubMed DOI

Endometriosis Knowledgebase: a gene-based resource on endometriosis.

Database : the journal of biological databases and curation Jan 1, 2019
Endometriosis is a complex, benign, estrogen-dependent gynecological disorder with an incidence of ~10% women in reproductive age. The implantation and growth of endometrial cells outside the uterus leads to the development of endometriosis. Endometr...
Databases, Genetic Endometriosis Polymorphism, Genetic Gene Ontology Data Curation Humans Female
View on PubMed DOI

[HIGH FREQUENCY OF CYP2C19 ULTRARAPID METABOLIZERS IN RUSSIAN PATIENTS WITH PEPTIC ULCER].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Jan 1, 2015
INTRODUCTION: The main enzyme responsible for metabolism of proton pump inhibitors (PPI) is cytochrome P-4502C19 (CYP2C19). Among all CYP2C19 polymorphisms ulrarapid CYP2C19*17 allele plays an important role in clinical practice as in CYP2C19*17 alle...
Polymorphism, Genetic Proton Pump Inhibitors Humans Peptic Ulcer Male Cytochrome P-450 CYP2C19 Moscow Middle Aged Retrospective Studies Genotype Female Gene Frequency Adult
View on PubMed

Application of artificial neural networks to link genetic and environmental factors to DNA methylation in colorectal cancer.

Epigenomics Jan 1, 2015
AIMS: We applied artificial neural networks (ANNs) to understand the connections among polymorphisms of genes involved in folate metabolism, clinico-pathological features and promoter methylation levels of MLH1, APC, CDKN2A(INK4A), MGMT and RASSF1A i...
DNA Methylation Colorectal Neoplasms Folic Acid Humans Neural Networks, Computer Life Style Male Female Gene-Environment Interaction Polymorphism, Genetic Aged Middle Aged Promoter Regions, Genetic Diet
View on PubMed DOI
Popular Topics
Recent Journals