AIMC Topic: Precision Medicine

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Improving the predictive potential of diffusion MRI in schizophrenia using normative models-Towards subject-level classification.

Human brain mapping
Diffusion MRI studies consistently report group differences in white matter between individuals diagnosed with schizophrenia and healthy controls. Nevertheless, the abnormalities found at the group-level are often not observed at the individual level...

In silico saturation mutagenesis of cancer genes.

Nature
Despite the existence of good catalogues of cancer genes, identifying the specific mutations of those genes that drive tumorigenesis across tumour types is still a largely unsolved problem. As a result, most mutations identified in cancer genes acros...

Future of machine learning in paediatrics.

Archives of disease in childhood
Machine learning (ML) is a branch of artificial intelligence (AI) that enables computers to learn without being explicitly programmed, through a combination of statistics and computer science. It encompasses a variety of techniques used to analyse an...

The path to precision medicine for MS, from AI to patient recruitment: an interview with Mauricio Farez and Helen Onuorah.

Communications biology
This year’s World Brain Day is focused on stopping Multiple Sclerosis (MS). Although amazing progress has resulted in the development of relatively successful MS therapies, access to such therapies is a major problem for most of the world. In additio...

The Trifecta of Single-Cell, Systems-Biology, and Machine-Learning Approaches.

Genes
Together, single-cell technologies and systems biology have been used to investigate previously unanswerable questions in biomedicine with unparalleled detail. Despite these advances, gaps in analytical capacity remain. Machine learning, which has re...

Performance Comparisons of AlexNet and GoogLeNet in Cell Growth Inhibition IC50 Prediction.

International journal of molecular sciences
Drug responses in cancer are diverse due to heterogenous genomic profiles. Drug responsiveness prediction is important in clinical response to specific cancer treatments. Recently, multi-class drug responsiveness models based on deep learning (DL) mo...

Patentability challenges associated with emerging pharmaceutical technologies.

Pharmaceutical patent analyst
According to the recent patent filing trends, it has been observed that certain pharmaceutical technologies are more popular than others and are commonly referred to as emerging technologies. The emerging technologies in the pharmaceutical sector inc...

Artificial intelligence-the future is now.

Journal of assisted reproduction and genetics
The pros and cons of artificial intelligence in assisted reproductive technology are presented.

Bone mineral density response prediction following osteoporosis treatment using machine learning to aid personalized therapy.

Scientific reports
Osteoporosis is a global health problem for ageing populations. The goals of osteoporosis treatment are to improve bone mineral density (BMD) and prevent fractures. One major obstacle that remains a great challenge to achieve the goals is how to sele...

A deep look into radiomics.

La Radiologia medica
Radiomics is a process that allows the extraction and analysis of quantitative data from medical images. It is an evolving field of research with many potential applications in medical imaging. The purpose of this review is to offer a deep look into ...