BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) and unstable angina (UA) often coexist in clinical practice, constituting a high-risk cardiovascular phenotype with a markedly increased incidence of major adverse cardiovascular even...
Traditional survival predictions for oral squamous cell carcinoma (OSCC) rely on TNM staging, which lacks individualized prognostic value. Clinical factors such as performance status, age, sex, and lifestyle affect outcomes but are underrepresented i...
Acute kidney injury is a common and critical complication in patients with community-acquired pneumonia who are admitted to intensive care units, substantially increasing their risk of short-term mortality. To enhance early clinical decision-making, ...
Gastric cancer (GC) is a leading cause of cancer-related mortality globally. Histone lactylation, an emerging post-translational modification, holds promise as a therapeutic target and prognostic biomarker, though its expression patterns and clinical...
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a growing global health challenge. Conventional diagnostic tools have limited sensitivity and specificity for early-stage disease. In this context, long non-coding RNAs (lncRNAs) have emerged as promisin...
Prognostic stratification of Hodgkin lymphoma (HL) patients in ICU remains challenging, with conventional scoring systems often overlooking pathophysiological biomarkers. This retrospective cohort study analyzed 1,908 HL patients from the MIMIC-IV da...
Emerging evidence highlights RNA N6-methyladenosine (m6A) modifications as pivotal regulators of tumorigenesis, yet the synergistic roles of m6A readers in the pathogenesis and prognosis of acute myeloid leukemia (AML) remains unclear. By leveraging ...
AJNR. American journal of neuroradiology
Dec 4, 2025
BACKGROUND AND PURPOSE: Predicting long-term clinical outcomes based on early acute ischemic stroke (AIS) information would be useful for many reasons, including patient counseling and clinical trial execution. This study investigates how different r...
INTRODUCTION: Prognostication at 90 and 180 days after thrombolysis for acute ischemic stroke (AIS) is critical, yet the temporal evolution of key predictors remains inadequately understood. The utility of machine learning for systematically comparin...
BACKGROUND: The Left Atrial-Ventricular Coupling Index (LACI), which quantifies the volumetric interaction between the left atrium and ventricle, has emerged as a promising prognostic marker for cardiovascular events.
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