AIMC Topic: Proline

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Single-Molecule SERS Discrimination of Proline from Hydroxyproline Assisted by a Deep Learning Model.

Nano letters Apr 17, 2025
Discriminating low-abundance hydroxylation is a crucial and unmet need for early disease diagnostics and therapeutic development due to the small hydroxyl group with 17.01 Da. While single-molecule surface-enhanced Raman spectroscopy (SERS) sensors c...
Hydroxylation Neural Networks, Computer Deep Learning Spectrum Analysis, Raman Proline Hydroxyproline
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Deep-learning based repurposing of FDA-approved drugs against dihydrofolate reductase and molecular dynamics study.

Journal of biomolecular structure & dynamics Apr 21, 2021
causes the fatal fungal bloodstream infection in humans called Candidiasis. Most of the species are resistant to the antifungals used to treat them. Drug-resistant poses very serious public health issues. To overcome this, the development of effec...
Humans Molecular Docking Simulation Deep Learning Drug Approval Rifampin Folic Acid Antagonists Aminopyridines Antifungal Agents Tetrahydrofolate Dehydrogenase Molecular Dynamics Simulation Benzodioxoles Sulfonamides United States United States Food and Drug Administration Candida albicans Proline Cyclopropanes Lactams, Macrocyclic Drug Repositioning Candidiasis
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Ritonavir-boosted paritaprevir, ombitasvir plus ribavirin could improve eGFR in patients with renal impairment and HCV: an Egyptian cohort.

Expert review of gastroenterology & hepatology Nov 13, 2018
BACKGROUND: The present study aimed at evaluation of changes in estimated glomerular filtration rate (eGFR) among chronic Hepatitis C virus (HCV) patients with chronic kidney disease (CKD) Stages 3-5 who were treated with 12 weeks of ritonavir-booste...
Glomerular Filtration Rate Humans Cyclopropanes Prospective Studies Recovery of Function Carbamates Female Adult Proline Egypt Lactams, Macrocyclic Antiviral Agents Male Aged Macrocyclic Compounds Genotype Middle Aged Young Adult Drug Therapy, Combination Kidney Hepatitis C, Chronic Ribavirin Renal Insufficiency, Chronic Valine Sustained Virologic Response Treatment Outcome Anilides Sulfonamides Hepacivirus Renal Dialysis Viral Load Time Factors
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Detecting Proline and Non-Proline Cis Isomers in Protein Structures from Sequences Using Deep Residual Ensemble Learning.

Journal of chemical information and modeling Aug 29, 2018
It has been long established that cis conformations of amino acid residues play many biologically important roles despite their rare occurrence in protein structure. Because of this rarity, few methods have been developed for predicting cis isomers f...
Proteins Amino Acid Sequence Proline Machine Learning
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: In Egypt, chronic hepatitis C virus (HCV) infection occurs in around 10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis, hepatocellular carcinoma, and mortality. Although HCV genotype 4 constitu...
Humans Macrocyclic Compounds Ribavirin Sustained Virologic Response Treatment Outcome Male Valine Follow-Up Studies Drug Administration Schedule Middle Aged Female Cyclopropanes Hepacivirus Anilides Adolescent Aged Egypt Administration, Oral Carbamates Antiviral Agents Aged, 80 and over Sulfonamides Proline Genotype Lactams, Macrocyclic Young Adult Ritonavir Liver Cirrhosis Drug Therapy, Combination Adult Hepatitis C, Chronic
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is increasing worldwide through immigration. HCV genotype 4 accounts for 20% of all infections, but clin...
Drug Therapy, Combination Hepatitis C, Chronic Valine Drug Administration Schedule Anilides Carbamates Cyclopropanes Sulfonamides Hepacivirus Proline Ritonavir Lactams, Macrocyclic Macrocyclic Compounds Ribavirin Sustained Virologic Response Aged Aged, 80 and over Young Adult Adult Male Middle Aged Adolescent Antiviral Agents Genotype Treatment Outcome Follow-Up Studies Humans Female
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Modulation of insulin aggregation by betaine and proline directly observed via real-time super-resolution microscopy.

Protein science : a publication of the Protein Society Jun 1, 2025
Protein aggregation is associated with a spectrum of neurodegenerative diseases. Although many small ligands have been found to modulate or inhibit protein aggregation, their molecular mechanisms remain unclear. One reason for this is the inherent he...
Animals Insulin Kinetics Proline Protein Aggregates Betaine Humans
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Examination of the relationship between D-amino acid profiles and cognitive function in individuals with mild cognitive impairment: a machine learning approach.

The international journal of neuropsychopharmacology Apr 11, 2025
BACKGROUND: The global prevalence of dementia is significantly increasing. Early detection and prevention strategies, particularly for mild cognitive impairment (MCI), are crucial but currently hindered by the lack of established biomarkers. Here, we...
Female Aged Aged, 80 and over Cross-Sectional Studies Male Middle Aged Humans Neural Networks, Computer Machine Learning Biomarkers Cognitive Dysfunction Support Vector Machine Proline Alanine
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Choline Proline Ionic Liquid-Functionalized FeO@SiO Nanoparticle Magnetic Solid Phase Extraction Coupled with High-Performance Liquid Chromatography for Analysis of Allura Red in Lipstick Sample.

Journal of cosmetic science Jan 1, 2021
A separation/analysis of allura red based on magnetic solid-phase extraction-high-performance liquid chromatography was developed. The extractant was prepared by functionalizing choline proline ionic liquid on FeO@SiO(FeO@SiO@[Ch][Pro]). Infl uences ...
Solid Phase Extraction Nanoparticles Azo Compounds Silicon Dioxide Choline Limit of Detection Ionic Liquids Magnetic Phenomena Proline Chromatography, High Pressure Liquid
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[A real-world study of paritaprevir/ritonavir-ombitasvir combined with dasabuvir in the treatment of genotype 1b chronic hepatitis C].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Dec 20, 2018
To recognize the efficacy and safety of paritaprevir/ritonavir-ombitasvir combined with dasabuvir (OBV/PTV/RTV+DSV) in the treatment of genotype 1b chronic hepatitis C. Patients with genotype 1b chronic hepatitis C who were admitted to the People's...
Drug Therapy, Combination Hepatitis C, Chronic Valine Anilides Carbamates Lactams, Macrocyclic Macrocyclic Compounds Ribavirin 2-Naphthylamine Uracil Treatment Outcome Humans Cyclopropanes Male Sulfonamides Middle Aged Hepacivirus China Proline Antiviral Agents Ritonavir Genotype
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