AIMC Topic: Pyrimidines

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Selective solid-phase extraction using molecularly imprinted polymer as a sorbent for the analysis of fenarimol in food samples.

Food chemistry Dec 29, 2015
In the present communication, a non-covalent fenarimol-imprinted polymer was synthesized by precipitation polymerization technique using methacrylic acid (MAA) as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker, and azo...
Polymers Solid Phase Extraction Molecular Imprinting Pyrimidines Food Quality
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Detection and direct readout of drugs in human urine using dynamic surface-enhanced Raman spectroscopy and support vector machines.

Analytical chemistry Feb 10, 2015
A new, novel, rapid method to detect and direct readout of drugs in human urine has been developed using dynamic surface-enhanced Raman spectroscopy (D-SERS) with portable Raman spectrometer on gold nanorods (GNRs) and a classification algorithm call...
Humans Algorithms Spectrum Analysis, Raman Support Vector Machine Gold Metal Nanoparticles Silver Surface Plasmon Resonance Dimethylnitrosamine Surface Properties Nanotubes Pyrimidines
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Explainable machine learning prediction of edema adverse events in patients treated with tepotinib.

Clinical and translational science Sep 1, 2024
Tepotinib is approved for the treatment of patients with non-small-cell lung cancer harboring MET exon 14 skipping alterations. While edema is the most prevalent adverse event (AE) and a known class effect of MET inhibitors including tepotinib, there...
Humans Machine Learning Female Aged Adult Male Middle Aged Antineoplastic Agents Lung Neoplasms Carcinoma, Non-Small-Cell Lung Clinical Trials, Phase II as Topic Piperidines Protein Kinase Inhibitors Pyrimidines Clinical Trials, Phase I as Topic Edema Pyridazines
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Design, Synthesis and Biological Evaluation of New Thieno[2,3- d]pyrimidines as Anti-inflammatory Agents.

Anti-inflammatory & anti-allergy agents in medicinal chemistry Jan 1, 2015
BACKGROUND: Long term use of NSAIDS is mainly accompanied by major health implications such as gastrointestinal erosions, ulcerations and nephrotoxicity. These side effects arise from local irritation by the carboxylic acid moiety, that is common to ...
Animals Male Drug Design Dinoprostone Rats, Wistar Anti-Inflammatory Agents Carrageenan Pyrimidines Edema
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