AIMC Topic: Radiopharmaceuticals

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Classification of amyloid status using machine learning with histograms of oriented 3D gradients.

NeuroImage. Clinical May 10, 2016
Brain amyloid burden may be quantitatively assessed from positron emission tomography imaging using standardised uptake value ratios. Using these ratios as an adjunct to visual image assessment has been shown to improve inter-reader reliability, howe...
Carbon Radioisotopes Ethylene Glycols Reproducibility of Results Positron-Emission Tomography Aged Aged, 80 and over Sensitivity and Specificity Stilbenes Radiopharmaceuticals Amyloid Alzheimer Disease Image Interpretation, Computer-Assisted Aniline Compounds Male Support Vector Machine Humans Brain Female
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Automated electrophilic radiosynthesis of [¹⁸F]FBPA using a modified nucleophilic GE TRACERlab FXFDG.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Jul 2, 2015
We modified a commercially available synthesis module for nucleophilic [(18)F]fluorinations (TRACERlab(TM) FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[(18)F]fluoro-4-borono-L-phenylalanine ([(18)F]FBPA) via direct electrophilic subst...
Boron Compounds Equipment Design Radiopharmaceuticals Electrons Materials Testing Equipment Failure Analysis Robotics Electron Transport Isotope Labeling Fluorine Radioisotopes Phenylalanine
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Enhancing spatial resolution of (18)F positron imaging with the Timepix detector by classification of primary fired pixels using support vector machine.

Physics in medicine and biology Jun 18, 2015
Position-sensitive positron cameras using silicon pixel detectors have been applied for some preclinical and intraoperative clinical applications. However, the spatial resolution of a positron camera is limited by positron multiple scattering in the ...
Fluorodeoxyglucose F18 Monte Carlo Method Vitaceae Radiopharmaceuticals Computer Simulation Electrons Support Vector Machine Positron-Emission Tomography Plant Leaves Image Interpretation, Computer-Assisted Humans Algorithms
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Fully-automated synthesis of 16β-(18)F-fluoro-5α-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine May 21, 2015
Noninvasive in vivo imaging of androgen receptor (AR) levels with positron emission tomography (PET) is becoming the primary tool in prostate cancer detection and staging. Of the potential (18)F-labeled PET tracers, (18)F-FDHT has clinically shown to...
Radiopharmaceuticals Drug Design Equipment Failure Analysis Rheology Robotics Dihydrotestosterone Fluorine Radioisotopes Equipment Design Isotope Labeling Specimen Handling Radionuclide Generators
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Automated radiosynthesis of [(18)F]ciprofloxacin.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Feb 27, 2015
We transferred the previously published manual synthesis of [(18)F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab(TM) FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing th...
Equipment Design Fluorine Radioisotopes Equipment Failure Analysis Ciprofloxacin Isotope Labeling Radiopharmaceuticals Robotics
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Prediction of revascularization after myocardial perfusion SPECT by machine learning in a large population.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Dec 6, 2014
OBJECTIVE: We aimed to investigate if early revascularization in patients with suspected coronary artery disease can be effectively predicted by integrating clinical data and quantitative image features derived from perfusion SPECT (MPS) by machine l...
Retrospective Studies Female Aged Sensitivity and Specificity Humans Machine Learning Algorithms Coronary Angiography Exercise Test Heart Coronary Artery Disease Radiopharmaceuticals Male Middle Aged Image Processing, Computer-Assisted Electrocardiography Thallium Radioisotopes Tomography, Emission-Computed, Single-Photon Myocardial Revascularization Myocardial Perfusion Imaging Technetium Tc 99m Sestamibi
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The method and efficacy of support vector machine classifiers based on texture features and multi-resolution histogram from (18)F-FDG PET-CT images for the evaluation of mediastinal lymph nodes in patients with lung cancer.

European journal of radiology Nov 18, 2014
OBJECTIVES: In clinical practice, image analysis is dependent on simply visual perception and the diagnostic efficacy of this analysis pattern is limited for mediastinal lymph nodes in patients with lung cancer. In order to improve diagnostic efficac...
Algorithms Radiopharmaceuticals Retrospective Studies Positron-Emission Tomography Tomography, X-Ray Computed ROC Curve Fluorodeoxyglucose F18 Female Aged Lung Neoplasms Humans Aged, 80 and over Lymph Nodes Male Support Vector Machine Middle Aged Lymphatic Metastasis
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Manifold regularized multitask feature learning for multimodality disease classification.

Human brain mapping Oct 3, 2014
Multimodality based methods have shown great advantages in classification of Alzheimer's disease (AD) and its prodromal stage, that is, mild cognitive impairment (MCI). Recently, multitask feature selection methods are typically used for joint select...
Aged Cognitive Dysfunction Magnetic Resonance Imaging Brain Mapping Alzheimer Disease Positron-Emission Tomography Pattern Recognition, Automated Multimodal Imaging Radiopharmaceuticals Artificial Intelligence Algorithms Databases, Factual Humans Brain Fluorodeoxyglucose F18
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Machine learning models for the differential diagnosis of vascular parkinsonism and Parkinson's disease using [(123)I]FP-CIT SPECT.

European journal of nuclear medicine and molecular imaging Aug 14, 2014
PURPOSE: The study's objective was to develop diagnostic predictive models using data from two commonly used [(123)I]FP-CIT SPECT assessment methods: region-of-interest (ROI) analysis and whole-brain voxel-based analysis.
Diagnosis, Differential Aged, 80 and over Radiopharmaceuticals Parkinson Disease, Secondary Humans Male Tomography, Emission-Computed, Single-Photon Image Processing, Computer-Assisted Tropanes Artificial Intelligence Parkinson Disease Female Aged
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FDG-PET Intensity Normalization Improves Radiomics-Based Survival Prediction in Patients with Oropharyngeal Cancer: A Comparison of the Standardized Uptake Value with Alternative Normalization Techniques.

AJNR. American journal of neuroradiology Nov 3, 2025
BACKGROUND AND PURPOSE: Despite the widespread research application of radiomics, there is a knowledge gap regarding the optimal voxel intensity normalization strategy for FDG-PET radiomics. We investigated the impact of 3 normalization strategies on...
Humans Machine Learning Prognosis Middle Aged Radiopharmaceuticals Positron-Emission Tomography Fluorodeoxyglucose F18 Oropharyngeal Neoplasms Female Aged Radiomics Male
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