AIMC Topic: Randomized Controlled Trials as Topic

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Identification of Non-Small Cell Lung Cancer Sensitive to Systemic Cancer Therapies Using Radiomics.

Clinical cancer research : an official journal of the American Association for Cancer Research Mar 20, 2020
PURPOSE: Using standard-of-care CT images obtained from patients with a diagnosis of non-small cell lung cancer (NSCLC), we defined radiomics signatures predicting the sensitivity of tumors to nivolumab, docetaxel, and gefitinib.
Female Survival Rate Male Disease Progression Machine Learning Prognosis Retrospective Studies Tomography, X-Ray Computed Clinical Trials, Phase II as Topic Nivolumab Docetaxel Clinical Trials, Phase III as Topic Gefitinib Lung Neoplasms Antineoplastic Combined Chemotherapy Protocols Carcinoma, Non-Small-Cell Lung Randomized Controlled Trials as Topic Humans
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Comparing machine and human reviewers to evaluate the risk of bias in randomized controlled trials.

Research synthesis methods Mar 3, 2020
BACKGROUND: Evidence from new health technologies is growing, along with demands for evidence to inform policy decisions, creating challenges in completing health technology assessments (HTAs)/systematic reviews (SRs) in a timely manner. Software can...
Risk Assessment Health Policy Randomized Controlled Trials as Topic Bias Machine Learning Software Reproducibility of Results Sensitivity and Specificity Outcome Assessment, Health Care Observer Variation Pattern Recognition, Automated Risk Humans
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Identifying treatment effects of an informal caregiver education intervention to increase days in the community and decrease caregiver distress: a machine-learning secondary analysis of subgroup effects in the HI-FIVES randomized clinical trial.

Trials Feb 14, 2020
BACKGROUND: Informal caregivers report substantial burden and depressive symptoms which predict higher rates of patient institutionalization. While caregiver education interventions may reduce caregiver distress and decrease the use of long-term inst...
Humans Machine Learning Female Aged Aged, 80 and over Age Factors Randomized Controlled Trials as Topic Data Interpretation, Statistical Veterans Institutionalization Long-Term Care Family Caregivers Male Stress, Psychological Middle Aged Cognitive Dysfunction Quality of Life Treatment Outcome Depression Follow-Up Studies
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How Artificial Intelligence Can Transform Randomized Controlled Trials.

Translational vision science & technology Feb 12, 2020
Artificial Intelligence Research Design Randomized Controlled Trials as Topic
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Machine learning analysis plans for randomised controlled trials: detecting treatment effect heterogeneity with strict control of type I error.

Trials Feb 10, 2020
BACKGROUND: Retrospective exploratory analyses of randomised controlled trials (RCTs) seeking to identify treatment effect heterogeneity (TEH) are prone to bias and false positives. Yet the desire to learn all we can from exhaustive data measurements...
Treatment Outcome Randomized Controlled Trials as Topic Plasmodium falciparum Antimalarials Artesunate Quinine Machine Learning Malaria, Falciparum Humans Algorithms Asia Retrospective Studies Adult
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Integrating machine-generated mortality estimates and behavioral nudges to promote serious illness conversations for cancer patients: Design and methods for a stepped-wedge cluster randomized controlled trial.

Contemporary clinical trials Jan 23, 2020
INTRODUCTION: Patients with cancer often receive care that is not aligned with their personal values and goals. Serious illness conversations (SICs) between clinicians and patients can help increase a patient's understanding of their prognosis, goals...
Neoplasms Randomized Controlled Trials as Topic Physician-Patient Relations Terminal Care Hospice Care Advance Care Planning Humans Machine Learning Oncologists Communication
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Investigating the use of data-driven artificial intelligence in computerised decision support systems for health and social care: A systematic review.

Health informatics journal Jan 22, 2020
There is growing interest in the potential of artificial intelligence to support decision-making in health and social care settings. There is, however, currently limited evidence of the effectiveness of these systems. The aim of this study was to inv...
Humans Artificial Intelligence Quality of Life Social Support Delivery of Health Care Randomized Controlled Trials as Topic Pregnancy Bayes Theorem Female Infant, Newborn
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Beyond the Randomized Clinical Trial: Innovative Data Science to Close the Pediatric Evidence Gap.

Clinical pharmacology and therapeutics Jan 22, 2020
Despite the application of advanced statistical and pharmacometric approaches to pediatric trial data, a large pediatric evidence gap still remains. Here, we discuss how to collect more data from children by using real-world data from electronic heal...
Humans Artificial Intelligence Machine Learning Data Science Child Pediatrics Inventions Randomized Controlled Trials as Topic Evidence-Based Medicine
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Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock - rationale and design of a multicenter randomized controlled superiority trial.

Trials Dec 18, 2019
BACKGROUND: Antibiotic exposure is often inadequate in critically ill patients with severe sepsis or septic shock and this is associated with worse outcomes. Despite markedly altered and rapidly changing pharmacokinetics in these patients, guidelines...
Equivalence Trials as Topic Artificial Intelligence Randomized Controlled Trials as Topic Research Design Drug Monitoring Big Data Female Anti-Bacterial Agents Netherlands Shock, Septic Humans Adult Kaplan-Meier Estimate Treatment Outcome Intensive Care Units Male Dose-Response Relationship, Drug Severity of Illness Index Multicenter Studies as Topic
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Clinical non-superiority of technology-assisted gait training with body weight support in patients with subacute stroke: A meta-analysis.

Annals of physical and rehabilitation medicine Oct 30, 2019
BACKGROUND: Technology-assisted gait training (TAGT) with body weight support (BWS) has been designed to provide high numbers of repetitions during stepping practice, but its benefits have been inconclusive.
Robotics Stroke Rehabilitation Male Gait Humans Middle Aged Exercise Test Body Weight Treatment Outcome Female Stroke Exercise Therapy Randomized Controlled Trials as Topic Aged Walking Orthotic Devices Adult Weight-Bearing Equivalence Trials as Topic
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