AIMC Topic: Rats, Sprague-Dawley
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Artificial Neural Network to Predict Varicocele Impact on Male Fertility through Testicular Endocannabinoid Gene Expression Profiles.
BioMed research international
Nov 13, 2018
The relationship between varicocele and fertility has always been a matter of debate because of the absence of predictive clinical indicators or molecular markers able to define the severity of this disease. Even though accumulated evidence demonstra...
A rapid LC-MS/MS method for simultaneous determination of quetiapine and duloxetine in rat plasma and its application to pharmacokinetic interaction study.
Journal of food and drug analysis
Aug 14, 2018
Combinations of new antidepressants like duloxetine and second-generation antipsychotics like quetiapine are used in clinical treatment of major depressive disorder, as well as in forensic toxicology scenarios. The drug-drug interaction (DDI) between...
Neural network-based model predictive control for type 1 diabetic rats on artificial pancreas system.
Medical & biological engineering & computing
Aug 1, 2018
Artificial pancreas system (APS) is a viable option to treat diabetic patients. Researchers, however, have not conclusively determined the best control method for APS. Due to intra-/inter-variability of insulin absorption and action, an individualize...
Determination of Optimal Heart Rate Variability Features Based on SVM-Recursive Feature Elimination for Cumulative Stress Monitoring Using ECG Sensor.
Sensors (Basel, Switzerland)
Jul 23, 2018
Routine stress monitoring in daily life can predict potentially serious health impacts. Effective stress monitoring in medical and healthcare fields is dependent upon accurate determination of stress-related features. In this study, we determined the...
Automated detection of electroencephalography artifacts in human, rodent and canine subjects using machine learning.
Journal of neuroscience methods
Jun 23, 2018
BACKGROUND: Electroencephalography (EEG) invariably contains extra-cranial artifacts that are commonly dealt with based on qualitative and subjective criteria. Failure to account for EEG artifacts compromises data interpretation.
A Capsule-Type Microrobot with Pick-and-Drop Motion for Targeted Drug and Cell Delivery.
Advanced healthcare materials
Feb 20, 2018
A capsule-type microrobot exhibits "pick-and-drop" (P&D) motion to hold a particle within a confined volume and transports it via a corkscrewing motion. The P&D motion is possible because the capsule-type microrobot has two parts: a plunger and a cap...
Determination of IMM-H004 and its active glucuronide metabolite in rat plasma and Ringer's solution by ultra-performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 29, 2017
IMM-H004 is a novel neuroprotective agent and its glucuronide metabolite IMM-H004G has similar protective effects against cerebral ischemic injury in vivo and in vitro. A specific and sensitive ultra-performance liquid chromatography-tandem mass spec...
Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.
European journal of medicinal chemistry
Dec 28, 2017
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheum...
Humans
Animals
Drug Design
Mice
Arthritis, Rheumatoid
Dogs
Rats
Microsomes, Liver
Protein Kinase Inhibitors
Pyrimidines
Agammaglobulinaemia Tyrosine Kinase
Haplorhini
Pyrroles
Protein-Tyrosine Kinases
Cell Proliferation
Structure-Activity Relationship
Rats, Sprague-Dawley
Models, Molecular
Dose-Response Relationship, Drug
Molecular Structure
Cell Line
A novel method for the rapid detection of post-translationally modified visinin-like protein 1 in rat models of brain injury.
Brain injury
Dec 28, 2017
BACKGROUND: Although elevated serum levels of visinin-like protein 1 (VILIP-1), a neuron-specific calcium sensor protein, are associated with ischaemic stroke, only a single study has evaluated VILIP-1 as a biomarker of traumatic brain injury (TBI). ...
Quantification and pharmacokinetics of alpinetin in rat plasma by UHPLC-MS/MS using protein precipitation coupled with dilution approach to eliminate matrix effects.
Journal of pharmaceutical and biomedical analysis
Dec 27, 2017
Alpinetin, a bioactive flavonoid, has attracted great attention due to its diverse therapeutic effects, namely anti-oxidant, anti-tumor and anti-inflammatory effects with low systemic toxicity. Various determination methods have been developed in qua...
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