AIMC Topic: Signal Transduction

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Melatonin Alleviates Retina Angiogenesis by Targeting Fibronectin and the VEGF Pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Diabetic retinopathy (DR) and retinopathy of prematurity (ROP) continue to be significant causes of vision impairment despite the well-established role of vascular endothelial growth factor (VEGF) in pathological angiogenesis. We still need to deeply...

Knockdown of CDKN1A Suppresses the IL-17 Pathway to Inhibit Oxidative Stress and Alleviate Autism Spectrum Disorder.

Journal of biochemical and molecular toxicology
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social interaction, communication deficits, and repetitive behaviors. However, the underlying molecular mechanisms remain elusive. This study aims to i...

Discovery of protein lactylation-associated biomarkers and their potential pathogenic mechanisms in recurrent spontaneous abortion.

International journal of biological macromolecules
Protein lactylation plays a critical regulatory role in various human diseases; however, its function in recurrent spontaneous abortion (RSA) remains unclear. In this study, we integrated scRNA-seq (GSE214607), bulk RNA-seq (GSE26787 and GSE165004) d...

Current concepts in the pathogenesis and clinical management of lymphangioleiomyomatosis.

Current opinion in pulmonary medicine
PURPOSE OF REVIEW: Lymphangioleiomyomatosis (LAM) is a systemic, low-grade, metastasizing neoplasm that predominantly affects women. This review demonstrates recent progression in this rare disease, from improved understanding of pathogenesis, to nov...

Computational modelling of aggressive B-cell lymphoma.

Biochemical Society transactions
Decades of research into the molecular signalling determinants of B cell fates, and recent progress in characterising the genetic drivers of lymphoma, has led to a detailed understanding of B cell malignancies but also revealed daunting heterogeneity...

Integrative exome sequencing and machine learning identify MICB and interferon pathway genes as contributors to SSc risk.

Annals of the rheumatic diseases
OBJECTIVES: Systemic sclerosis (SSc) is a complex autoimmune disease with both known and unidentified genetic contributors. While genome-wide association studies (GWAS) have implicated multiple loci, many reside in noncoding regions. We aimed to iden...

Integrating network pharmacology and experimental validation to advance psoriasis treatment: Multi-target mechanistic elucidation of medicinal herbs and natural compounds.

Autoimmunity reviews
BACKGROUND: Psoriasis, a chronic immune-mediated inflammatory disease (IMID), presents significant therapeutic challenges, necessitating exploration of alternative treatments like medicinal herbs (MH) and natural compounds (NC). Network pharmacology ...

Multi-omics identifies OSM-OSMR as a key receptor-ligand in the tumor environment of endometrial adenocarcinoma.

International immunopharmacology
Endometrial adenocarcinoma carries a bleak prognosis, and the molecular markers that evaluate the progression of endometrial adenocarcinoma to advanced stages remain uncertain. Cell-cell communication plays a crucial role in the tumor microenvironmen...

[Advances in mechanotransduction signaling pathways in distraction osteogenesis].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
OBJECTIVE: To review the role and research progress of mechanotransduction signaling pathway in distraction osteogenesis, so as to provide theoretical basis and reference for clinical treatment.

Artificial Intelligence Captures Pseudo-Intelligence Evolved in the Chemical Architecture of the Multifaceted Signal Transducer, TAK1.

Journal of chemical information and modeling
TAK1, a multifunctional kinase, possesses intramolecular interactions that are capacitated to recognize and process diverse forms of chemical and mechanical forces, which ultimately translate into a convergent catalytic function. By elucidating a dua...