AIMC Topic: Squamous Cell Carcinoma of Head and Neck

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Transoral robotic surgery for the management of head and neck squamous cell carcinoma of unknown primary.

Acta oto-laryngologica
CONCLUSION: The addition of transoral robotic surgery (TORS) in the diagnostic management of patients classified with head and neck squamous cell carcinoma of unknown primary (SCCUP) is promising and appears to improve detection rates of the primary ...

Machine learning and explainable artificial intelligence reveals the MicroRNAs associated with survival of head and neck squamous cell carcinoma patients.

Computational biology and chemistry
Dysregulated microRNAs (miRNAs) play a significant role in cancer development and metastasis. In literature, miRNAs have been used for the survival prediction of different types of cancers using AI. Although AI is useful for diagnosis and prognosis p...

Machine learning explainability for survival outcome in head and neck squamous cell carcinoma.

International journal of medical informatics
BACKGROUND: Diagnosis and treatment of head and neck squamous cell carcinoma (HNSCC) induces psychological variables and treatment-related toxicity in patients. The evaluation of outcomes is warranted for effective treatment planning and improved dis...

Development and experimental verification of a prognosis model for hypoxia- and lactate metabolism-associated genes in HNSCC.

Medicine
Hypoxia and lactate metabolism are both distinctive characteristics of cancerous cells. Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent forms of cancer. The objective of this study was to construct a prognostic model of gen...

Transcriptomics-based exploration of ubiquitination-related biomarkers and potential molecular mechanisms in laryngeal squamous cell carcinoma.

BMC medical genomics
BACKGROUND: One of the most common and prevalent cancers is laryngeal squamous cell carcinoma (LSCC), which poses a great threat to the life and health of the patient. Nonetheless, it has been demonstrated that ubiquitination is crucial for the devel...

Multiparameter MRI-based model integrating radiomics and deep learning for preoperative staging of laryngeal squamous cell carcinoma.

Scientific reports
The accurate preoperative staging of laryngeal squamous cell carcinoma (LSCC) provides valuable guidance for clinical decision-making. The objective of this study was to establish a multiparametric MRI model using radiomics and deep learning (DL) to ...

Identification of a telomere-related gene signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma by integrated analysis of machine learning and Mendelian randomization.

Medicine
Telomere-related genes (TRGs) are vital in diverse tumor types. Nevertheless, there is a notable lack of in-depth research concerning their significance in head and neck squamous cell carcinoma (HNSCC). In this context, the present study aims to asse...

Machine learning-driven identification of exosome- related biomarkers in head and neck squamous cell carcinoma.

Frontiers in immunology
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a common cancer associated with elevated mortality rates. Exosomes, diminutive extracellular vesicles, significantly contribute to tumour development, immunological evasion, and treatment r...

A machine learning approach to predict HPV positivity of oropharyngeal squamous cell carcinoma.

Pathologica
HPV status is an important prognostic factor in oropharyngeal squamous cell carcinoma (OPSCC), with HPV-positive tumors associated with better overall survival. To determine HPV status, we rely on the immunohistochemical investigation for expression ...

Tailoring nonsurgical therapy for elderly patients with head and neck squamous cell carcinoma: A deep learning-based approach.

Medicine
To assess deep learning models for personalized chemotherapy selection and quantify the impact of baseline characteristics on treatment efficacy for elderly head and neck squamous cell carcinoma (HNSCC) patients who are not surgery candidates. A comp...