AIMC Topic: Surface Properties
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Effect of roll compaction on granule size distribution of microcrystalline cellulose-mannitol mixtures: computational intelligence modeling and parametric analysis.
Drug design, development and therapy
Jan 18, 2017
Dry granulation using roll compaction is a typical unit operation for producing solid dosage forms in the pharmaceutical industry. Dry granulation is commonly used if the powder mixture is sensitive to heat and moisture and has poor flow properties. ...
Computational intelligence models to predict porosity of tablets using minimum features.
Drug design, development and therapy
Jan 12, 2017
The effects of different formulations and manufacturing process conditions on the physical properties of a solid dosage form are of importance to the pharmaceutical industry. It is vital to have in-depth understanding of the material properties and g...
Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.
Journal of colloid and interface science
Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Polypropylenes
Surface Properties
Ibuprofen
Anhydrides
Fumarates
Humans
Micelles
Animals
Prodrugs
Nanoparticles
HeLa Cells
Hydrolysis
Hydrophobic and Hydrophilic Interactions
Solubility
Anti-Inflammatory Agents, Non-Steroidal
Drug Liberation
Cell Line
Rabbits
Cell Survival
Hydrogen-Ion Concentration
Drug Carriers
Polyethylene Glycols
Controlled surface morphology and hydrophilicity of polycaprolactone toward human retinal pigment epithelium cells.
Materials science & engineering. C, Materials for biological applications
Nov 24, 2016
Applying scaffolds as a bed to enhance cell proliferation and even differentiation is one of the treatment of retina diseases such as age-related macular degeneration (AMD) which deteriorating photoreceptors and finally happening blindness. In this s...
Estimation of design space for an extrusion-spheronization process using response surface methodology and artificial neural network modelling.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
May 14, 2016
The application of the Quality by Design principles is one of the key issues of the recent pharmaceutical developments. In the past decade a lot of knowledge was collected about the practical realization of the concept, but there are still a lot of u...
Texture- and deformability-based surface recognition by tactile image analysis.
Medical & biological engineering & computing
Mar 23, 2016
Deformability and texture are two unique object characteristics which are essential for appropriate surface recognition by tactile exploration. Tactile sensation is required to be incorporated in artificial arms for rehabilitative and other human-com...
Fuzzy logic inference-based Pavement Friction Management and real-time slippery warning systems: A proof of concept study.
Accident; analysis and prevention
Feb 22, 2016
Minimizing roadway crashes and fatalities is one of the primary objectives of highway engineers, and can be achieved in part through appropriate maintenance practices. Maintaining an appropriate level of friction is a crucial maintenance practice, du...
Nanocomposites of gold nanoparticles and graphene oxide towards an stable label-free electrochemical immunosensor for detection of cardiac marker troponin-I.
Analytica chimica acta
Dec 30, 2015
A stable label-free amperometric immunosensor is presented based on gold nanoparticles and graphene oxide nanocomposites for detection of cardiac troponin-I in the early diagnosis of myocardial infarction. For designing of the sensing platform, first...
Inhibition of bacterial surface colonization by immobilized silver nanoparticles depends critically on the planktonic bacterial concentration.
Journal of colloid and interface science
Dec 23, 2015
Immobilization of antimicrobial silver nanoparticles (AgNPs) on surfaces has been proposed as a method to inhibit biofouling or as a possible route by which incidental releases of AgNPs may interfere with biofilms in the natural environment or in was...
Preparation of Concentrated Chitosan/DNA Nanoparticle Formulations by Lyophilization for Gene Delivery at Clinically Relevant Dosages.
Journal of pharmaceutical sciences
Dec 23, 2015
Chitosan/DNA polyplexes have been optimized for efficient and safe in vitro and in vivo gene delivery. Clinical application of this technology requires the development of formulations with higher concentrations to reach therapeutic dosages. Polyplexe...
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