AIMC Topic: Treatment Outcome

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Personalized azithromycin treatment rules for children with watery diarrhea using machine learning.

Nature communications
We use machine learning to identify innovative strategies to target azithromycin to the children with watery diarrhea who are most likely to benefit. Using data from a randomized trial of azithromycin for watery diarrhea (NCT03130114), we develop per...

Treatment Response Evaluation in Prostate Cancer Using PSMA PET/CT.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
In recent years, there has been a headlong rush into the use of prostate-specific membrane antigen (PSMA)-targeted PET for the staging and restaging of men with prostate cancer (PC). To date, there have been regulatory approvals for PSMA PET for purp...

Individual muscle strengths in rehabilitation outcomes of distal radius fracture.

Journal of neuroengineering and rehabilitation
BACKGROUND: Distal radius fractures (DRFs) are common fracture types and elderly patients often struggle to achieve functional recovery, which could be overcome by precise rehabilitation. This study aims to develop an innovative approach for acquirin...

Sleep disturbances and PTSD: identifying baseline predictors of insomnia response in an intensive treatment programme.

European journal of psychotraumatology
This study examined whether baseline demographic and clinical variables could predict clinically significant reductions in insomnia symptoms among veterans receiving a 2-week Cognitive Processing Therapy (CPT)-based intensive PTSD treatment programm...

Multimodal deep learning for predicting neoadjuvant treatment outcomes in breast cancer: a systematic review.

Biology direct
BACKGROUND: Pathological complete response (pCR) to neoadjuvant systemic therapy (NAST) is an established prognostic marker in breast cancer (BC). Multimodal deep learning (DL), integrating diverse data sources (radiology, pathology, omics, clinical)...

Neural mechanisms underlying the improvement of gait disturbances in stroke patients through robot-assisted gait training based on QEEG and fNIRS: a randomized controlled study.

Journal of neuroengineering and rehabilitation
BACKGROUND: Robot-assisted gait training is more effective in improving lower limb function and walking ability in stroke patients compared to conventional rehabilitation, but the neural mechanisms remain unclear. This study aims to explore the effec...

Extremity Soft Tissue Sarcoma Reconstruction Nomograms: A Clinicoradiomic, Machine Learning-Powered Predictor of Postoperative Outcomes.

JCO clinical cancer informatics
PURPOSE: The choice of wound closure modality after limb-sparing extremity soft-tissue sarcoma (eSTS) resection is fraught with uncertainty. Leveraging machine learning and clinicoradiomic data, we developed Sarcoma Reconstruction Nomograms (SARCON),...

Cone-beam computed tomography-based online adaptive radiotherapy of esophageal cancer in the neoadjuvant setting: Dosimetric analysis, toxicity and treatment response.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
BACKGROUND AND PURPOSE: Chemoradiotherapy (CRT) followed by surgery is a treatment option for esophageal cancer (EC). However, concerns persist regarding cardiopulmonary toxicity and inconsistent daily target coverage due to anatomical changes. To ad...

Predicting mortality risk following major lower extremity amputation using machine learning.

Journal of vascular surgery
OBJECTIVE: Major lower extremity amputation for advanced vascular disease involves significant perioperative risks. Although outcome prediction tools could aid in clinical decision-making, they remain limited. To address this, we developed machine le...