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Mitochondrial haplogroup A2 is associated with increased COVID-19 mortality in an admixed Brazilian population.
Scientific reports
Jul 1, 2025
Mitochondria play a crucial role in cellular respiration and immune responses. Mitochondrial DNA (mtDNA) haplogroups and variants have been associated with various diseases, including COVID-19. This study analyzed complete mtDNA sequences from 467 Br...
Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.
Nature communications
Jul 1, 2025
Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detect...
Automatic pain classification in older patients with hip fracture based on multimodal information fusion.
Scientific reports
Jul 1, 2025
Given the limitations of unimodal pain recognition approaches, this study aimed to develop a multimodal pain recognition system for older patients with hip fractures using multimodal information fusion. The proposed system employs ResNet-50 for facia...
Auto-Segmentation via deep-learning approaches for the assessment of flap volume after reconstructive surgery or radiotherapy in head and neck cancer.
Scientific reports
Jul 1, 2025
Reconstructive flap surgery aims to restore the substance and function losses associated with tumor resection. Automatic flap segmentation could allow quantification of flap volume and correlations with functional outcomes after surgery or post-opera...
Predicting diabetic peripheral neuropathy through advanced plantar pressure analysis: a machine learning approach.
Scientific reports
Jul 1, 2025
Diabetic foot Ulceration (DFU) is a severe complication of diabetic foot syndrome, often leading to amputation. In patients with neuropathy, ulcer formation is facilitated by elevated plantar tissue stress under insensate feet. This study presents a ...
Integrated artificial intelligence in healthcare and the patient's experience of care.
Scientific reports
Jul 1, 2025
Healthcare is plagued with many problems that Artificial Intelligence (AI) can ameliorate or sometimes amplify. Regardless, AI is changing the way we reason towards solutions, especially at the frontier of public health applications where autonomous ...
Preoperative prediction of major adverse outcomes after total arch replacement in acute type A aortic dissection based on machine learning ensemble.
Scientific reports
Jul 1, 2025
A machine learning model was developed and validated to predict postoperative complications in patients with acute type A aortic dissection (ATAAD) who underwent total arch replacement combined with frozen elephant trunk (TAR + FET), with the goal of...
Integrated analysis of shared gene expression signatures and immune microenvironment heterogeneity in type 2 diabetes mellitus and colorectal cancer.
Scientific reports
Jul 1, 2025
Emerging evidence suggests a bidirectional relationship between colorectal cancer (CRC) and type 2 diabetes mellitus (T2DM), yet the shared molecular mechanisms and prognostic biomarkers remain poorly characterized. This study aimed to identify novel...
Machine learning to improve predictive performance of prehospital early warning scores.
Scientific reports
Jul 1, 2025
Early warning scores are used to assess acute patients' risk of being in a critical situation, allowing for early appropriate treatment, avoiding critical outcomes. The early warning scores use changes in vital signs to provide an assessment, however...
Proteomic risk scores for predicting common diseases using linear and neural network models in the UK biobank.
Scientific reports
Jul 1, 2025
Plasma proteomics provides a unique opportunity to enhance disease prediction by capturing protein expression patterns linked to diverse pathological processes. Leveraging data from 2,923 proteins measured in 53,030 UK Biobank participants, we develo...
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