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Androgen Antagonists

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[Downregulation of PTTG1 expression inhibits the proliferation and invasiveness and promotes the apoptosis of human prostate cancer LNCaP-AI cells].

Zhonghua nan ke xue = National journal of andrology 29723450
OBJECTIVE: To investigate the effects of down-regulation of PTTG1 expression on the proliferation, invasiveness and apoptosis of androgen-independent human prostate cancer LNCaP-AI cells and their sensitivity to androgen antagonists.
Androgen Antagonists Apoptosis Cell Line, Tumor Cell Proliferation Down-Regulation Humans Male Neoplasm Invasiveness Prostatic Neoplasms RNA, Small Interfering Securin Time Factors Transfection
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Post prostatectomy outcomes of patients with high-risk prostate cancer treated with neoadjuvant androgen blockade.

Prostate cancer and prostatic diseases 29263420
BACKGROUND: Patients with high-risk prostate cancer have an increased likelihood of experiencing a relapse following radical prostatectomy (RP). We previously conducted three neoadjuvant androgen-deprivation therapy (ADT) trials prior to RP in unfavo...
Aged Androgen Antagonists Disease-Free Survival Follow-Up Studies Humans Kallikreins Male Middle Aged Multicenter Studies as Topic Neoadjuvant Therapy Neoplasm Recurrence, Local Neoplasm Staging Prostate Prostate-Specific Antigen Prostatectomy Prostatic Neoplasms Randomized Controlled Trials as Topic Treatment Outcome
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Seven-Month Prostate-Specific Antigen Is Prognostic in Metastatic Hormone-Sensitive Prostate Cancer Treated With Androgen Deprivation With or Without Docetaxel.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29261442
Purpose We evaluated the relationship between prostate-specific antigen (PSA) and overall survival in the context of a prospectively randomized clinical trial comparing androgen-deprivation therapy (ADT) plus docetaxel with ADT alone for initial meta...
Adult Aged Aged, 80 and over Androgen Antagonists Antineoplastic Combined Chemotherapy Protocols Databases, Factual Docetaxel Humans Kallikreins Male Middle Aged Neoplasm Metastasis Neoplasms, Hormone-Dependent Prostate-Specific Antigen Prostatic Neoplasms Randomized Controlled Trials as Topic Retrospective Studies Time Factors Treatment Outcome
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Effect of Long-Term Hormonal Therapy (vs Short-Term Hormonal Therapy): A Secondary Analysis of Intermediate-Risk Prostate Cancer Patients Treated on NRG Oncology RTOG 9202.

International journal of radiation oncology, biology, physics 28126300
PURPOSE: NRG Oncology RTOG 9202 was a randomized trial testing long-term adjuvant androgen deprivation (LTAD) versus initial androgen deprivation only (STAD) with external beam radiation therapy (RT) in mostly high-risk and some intermediate-risk pro...
Adenocarcinoma Aged Aged, 80 and over Androgen Antagonists Antineoplastic Agents, Hormonal Combined Modality Therapy Disease-Free Survival Drug Administration Schedule Humans Kaplan-Meier Estimate Male Middle Aged Neoplasm Grading Prostate-Specific Antigen Prostatic Neoplasms Radiotherapy, Conformal Retrospective Studies Risk Survival Rate Time Factors Treatment Outcome
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Sentinel Lymph Node Dissection to Select Clinically Node-negative Prostate Cancer Patients for Pelvic Radiation Therapy: Effect on Biochemical Recurrence and Systemic Progression.

International journal of radiation oncology, biology, physics 28068243
PURPOSE: To assess the efficacy of robotic-assisted laparoscopic sentinel lymph node (SLN) dissection (SLND) to select those patients with prostate cancer (PCa) who would benefit from additional pelvic external beam radiation therapy and long-term an...
Aged Androgen Antagonists Disease Progression Humans Lymphatic Irradiation Lymphatic Metastasis Male Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Nomograms Patient Selection Pelvis Prostate-Specific Antigen Prostatic Neoplasms Radiotherapy, Conformal Robotic Surgical Procedures Sentinel Lymph Node Biopsy Statistics, Nonparametric
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Duration of Androgen Deprivation Therapy for High-Risk Prostate Cancer: Application of Randomized Trial Data in a Tertiary Referral Cancer Center.

Clinical genitourinary cancer 26778006
INTRODUCTION: We evaluated the incidence and predictors of the use of long-term (2-3 years) versus shorter term androgen deprivation therapy (ADT) in radiation-managed men with high-risk prostate cancer.
Androgen Antagonists Drug Administration Schedule Humans Male Neoplasm Grading Practice Patterns, Physicians' Prostate-Specific Antigen Prostatic Neoplasms Regression Analysis Tertiary Care Centers Treatment Outcome
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Is modern external beam radiotherapy with androgen deprivation therapy still a viable alternative for prostate cancer in an era of robotic surgery and brachytherapy: a comparison of Australian series.

Journal of medical imaging and radiation oncology 25588566
INTRODUCTION: We compare the results of modern external-beam radiotherapy (EBRT), using combined androgen deprivation and dose-escalated intensity-modulated radiotherapy with MRI-CT fusion and daily image guidance with fiducial markers (DE-IG-IMRT), ...
Aged Aged, 80 and over Androgen Antagonists Australia Brachytherapy Chemoradiotherapy Disease-Free Survival Humans Male Middle Aged Prevalence Prostatic Neoplasms Radiotherapy, Conformal Retrospective Studies Risk Factors Robotics Surgery, Computer-Assisted Survival Rate Treatment Outcome
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Machine Learning on a Genome-wide Association Study to Predict Late Genitourinary Toxicity After Prostate Radiation Therapy.

International journal of radiation oncology, biology, physics 29502932
PURPOSE: Late genitourinary (GU) toxicity after radiation therapy limits the quality of life of prostate cancer survivors; however, efforts to explain GU toxicity using patient and dose information have remained unsuccessful. We identified patients w...
Androgen Antagonists Area Under Curve Brachytherapy Confidence Intervals Genome-Wide Association Study Genotyping Techniques Humans Lower Urinary Tract Symptoms Machine Learning Male Nocturia Polymorphism, Single Nucleotide Predictive Value of Tests Prostatic Neoplasms Quality of Life Regression Analysis Reproducibility of Results Risk Symptom Assessment Urinary Retention Urination Urination Disorders Urogenital System
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