AIMC Topic: Androgen Antagonists

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Post prostatectomy outcomes of patients with high-risk prostate cancer treated with neoadjuvant androgen blockade.

Prostate cancer and prostatic diseases Dec 20, 2017
BACKGROUND: Patients with high-risk prostate cancer have an increased likelihood of experiencing a relapse following radical prostatectomy (RP). We previously conducted three neoadjuvant androgen-deprivation therapy (ADT) trials prior to RP in unfavo...
Prostate-Specific Antigen Prostate Androgen Antagonists Neoplasm Recurrence, Local Disease-Free Survival Follow-Up Studies Humans Multicenter Studies as Topic Aged Prostatectomy Randomized Controlled Trials as Topic Male Kallikreins Prostatic Neoplasms Middle Aged Neoplasm Staging Treatment Outcome Neoadjuvant Therapy
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Seven-Month Prostate-Specific Antigen Is Prognostic in Metastatic Hormone-Sensitive Prostate Cancer Treated With Androgen Deprivation With or Without Docetaxel.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology Dec 20, 2017
Purpose We evaluated the relationship between prostate-specific antigen (PSA) and overall survival in the context of a prospectively randomized clinical trial comparing androgen-deprivation therapy (ADT) plus docetaxel with ADT alone for initial meta...
Kallikreins Neoplasms, Hormone-Dependent Prostatic Neoplasms Prostate-Specific Antigen Androgen Antagonists Docetaxel Neoplasm Metastasis Aged Time Factors Antineoplastic Combined Chemotherapy Protocols Aged, 80 and over Treatment Outcome Adult Randomized Controlled Trials as Topic Humans Male Databases, Factual Middle Aged Retrospective Studies
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Effect of Long-Term Hormonal Therapy (vs Short-Term Hormonal Therapy): A Secondary Analysis of Intermediate-Risk Prostate Cancer Patients Treated on NRG Oncology RTOG 9202.

International journal of radiation oncology, biology, physics Nov 8, 2016
PURPOSE: NRG Oncology RTOG 9202 was a randomized trial testing long-term adjuvant androgen deprivation (LTAD) versus initial androgen deprivation only (STAD) with external beam radiation therapy (RT) in mostly high-risk and some intermediate-risk pro...
Humans Retrospective Studies Aged Aged, 80 and over Survival Rate Male Middle Aged Time Factors Risk Kaplan-Meier Estimate Antineoplastic Agents, Hormonal Androgen Antagonists Combined Modality Therapy Disease-Free Survival Radiotherapy, Conformal Drug Administration Schedule Treatment Outcome Adenocarcinoma Prostatic Neoplasms Prostate-Specific Antigen Neoplasm Grading
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Sentinel Lymph Node Dissection to Select Clinically Node-negative Prostate Cancer Patients for Pelvic Radiation Therapy: Effect on Biochemical Recurrence and Systemic Progression.

International journal of radiation oncology, biology, physics Oct 19, 2016
PURPOSE: To assess the efficacy of robotic-assisted laparoscopic sentinel lymph node (SLN) dissection (SLND) to select those patients with prostate cancer (PCa) who would benefit from additional pelvic external beam radiation therapy and long-term an...
Statistics, Nonparametric Sentinel Lymph Node Biopsy Lymphatic Irradiation Humans Aged Pelvis Male Androgen Antagonists Middle Aged Neoplasm Recurrence, Local Prostatic Neoplasms Disease Progression Patient Selection Neoplasm Staging Nomograms Radiotherapy, Conformal Prostate-Specific Antigen Lymphatic Metastasis Robotic Surgical Procedures
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Duration of Androgen Deprivation Therapy for High-Risk Prostate Cancer: Application of Randomized Trial Data in a Tertiary Referral Cancer Center.

Clinical genitourinary cancer Dec 17, 2015
INTRODUCTION: We evaluated the incidence and predictors of the use of long-term (2-3 years) versus shorter term androgen deprivation therapy (ADT) in radiation-managed men with high-risk prostate cancer.
Tertiary Care Centers Androgen Antagonists Practice Patterns, Physicians' Drug Administration Schedule Humans Male Treatment Outcome Regression Analysis Prostatic Neoplasms Prostate-Specific Antigen Neoplasm Grading
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Is modern external beam radiotherapy with androgen deprivation therapy still a viable alternative for prostate cancer in an era of robotic surgery and brachytherapy: a comparison of Australian series.

Journal of medical imaging and radiation oncology Jan 15, 2015
INTRODUCTION: We compare the results of modern external-beam radiotherapy (EBRT), using combined androgen deprivation and dose-escalated intensity-modulated radiotherapy with MRI-CT fusion and daily image guidance with fiducial markers (DE-IG-IMRT), ...
Retrospective Studies Risk Factors Aged Aged, 80 and over Survival Rate Humans Robotics Prostatic Neoplasms Surgery, Computer-Assisted Androgen Antagonists Disease-Free Survival Male Middle Aged Prevalence Treatment Outcome Australia Radiotherapy, Conformal Brachytherapy Chemoradiotherapy
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Recent advancements in personalized management of prostate cancer biochemical recurrence after radical prostatectomy.

Current opinion in urology Sep 1, 2025
PURPOSE OF REVIEW: Biochemical recurrence (BCR) after radical prostatectomy exhibits heterogeneous prognostic implications. Recent advancements in imaging and biomarkers have high potential for personalizing care.
Precision Medicine Prognosis Biomarkers, Tumor Male Risk Assessment Humans Artificial Intelligence Androgen Antagonists Neoplasm Recurrence, Local Salvage Therapy Prostatectomy Kallikreins Positron Emission Tomography Computed Tomography Prostatic Neoplasms Prostate-Specific Antigen Neoplasm Grading Prostate
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Pilot study of an artificial intelligence-based deep learning algorithm to predict time to castration-resistant prostate cancer for metastatic hormone-naïve prostate cancer.

Japanese journal of clinical oncology Sep 18, 2022
The object in this study is to develop an artificial intelligence-based deep learning algorithm for prediction of time to castration-resistant prostate cancer by combined androgen blockade therapy in metastatic hormone-naïve prostate cancer. We inclu...
Androgen Antagonists Humans Prostatic Neoplasms, Castration-Resistant Artificial Intelligence Androgens Male Deep Learning Pilot Projects
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Low Risk of Venous Thromboembolism After Robot-assisted Radical Prostatectomy Through Systemic Image Assessment: A Prospective Study.

In vivo (Athens, Greece) Jan 1, 2022
BACKGROUND/AIM: The aim of the study was to evaluate the risk of venous thromboembolism (VTE) after robot-assisted radical prostatectomy (RARP) and discuss whether a uniform prophylaxis for VTE after radical prostatectomy is also suitable for robotic...
Prostatic Neoplasms Androgen Antagonists Venous Thromboembolism Lymphocele Prostatectomy Prospective Studies Risk Factors Male Urinary Bladder Neoplasms Robotics Humans
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[Downregulation of PTTG1 expression inhibits the proliferation and invasiveness and promotes the apoptosis of human prostate cancer LNCaP-AI cells].

Zhonghua nan ke xue = National journal of andrology Jul 1, 2017
OBJECTIVE: To investigate the effects of down-regulation of PTTG1 expression on the proliferation, invasiveness and apoptosis of androgen-independent human prostate cancer LNCaP-AI cells and their sensitivity to androgen antagonists.
RNA, Small Interfering Cell Proliferation Humans Transfection Apoptosis Male Neoplasm Invasiveness Securin Time Factors Prostatic Neoplasms Cell Line, Tumor Down-Regulation Androgen Antagonists
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