AIMC Topic: Area Under Curve

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Using Blood Indexes to Predict Overweight Statuses: An Extreme Learning Machine-Based Approach.

PloS one
The number of the overweight people continues to rise across the world. Studies have shown that being overweight can increase health risks, such as high blood pressure, diabetes mellitus, coronary heart disease, and certain forms of cancer. Therefore...

Classification of radiology reports for falls in an HIV study cohort.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: To identify patients in a human immunodeficiency virus (HIV) study cohort who have fallen by applying supervised machine learning methods to radiology reports of the cohort.

Automated mutual exclusion rules discovery for structured observational codes in echocardiography reporting.

AMIA ... Annual Symposium proceedings. AMIA Symposium
Structured reporting in medicine has been argued to support and enhance machine-assisted processing and communication of pertinent information. Retrospective studies showed that structured echocardiography reports, constructed through point-and-click...

Predicting drug side effects by multi-label learning and ensemble learning.

BMC bioinformatics
BACKGROUND: Predicting drug side effects is an important topic in the drug discovery. Although several machine learning methods have been proposed to predict side effects, there is still space for improvements. Firstly, the side effect prediction is ...

DisPredict: A Predictor of Disordered Protein Using Optimized RBF Kernel.

PloS one
Intrinsically disordered proteins or, regions perform important biological functions through their dynamic conformations during binding. Thus accurate identification of these disordered regions have significant implications in proper annotation of fu...

Bioequivalence of fixed-dose combinations of dapagliflozin and metformin with single-component tablets in healthy subjects and the effect of food on bioavailability.

Clinical pharmacology in drug development
The pharmacokinetics (PK) of dapagliflozin and metformin administered as fixed-dose combination (FDC) tablets (2.5 mg dapagliflozin/850 mg metformin or 5 mg dapagliflozin/1000 mg metformin) or as separate tablets in healthy subjects were evaluated in...

The advantages of combination therapy on hypertension: development of immediate release perindopril-indapamide tablet and assessment of bioequivalence studies.

Pharmaceutical development and technology
Hypertension has a major associated risk for organ damage and mortality, which is further heightened in patients with prior cardiovascular events, comorbid diabetes mellitus, microalbuminuria and renal impairment. Convers Plus tablet including perind...

Real alerts and artifact classification in archived multi-signal vital sign monitoring data: implications for mining big data.

Journal of clinical monitoring and computing
Huge hospital information system databases can be mined for knowledge discovery and decision support, but artifact in stored non-invasive vital sign (VS) high-frequency data streams limits its use. We used machine-learning (ML) algorithms trained on ...

Bioequivalence and comparative pharmacodynamics of insulin lispro 200 U/mL relative to insulin lispro (Humalog®) 100 U/mL.

Clinical pharmacology in drug development
Insulin lispro 200 U/mL (IL200) is a new strength formulation of insulin lispro (Humalog®, IL100), developed as an option for diabetic patients on higher daily mealtime insulin doses. This phase 1, open-label, 2-sequence, 4-period crossover, randomiz...