Cancer pharmacogenetics has become a cornerstone of precision oncology. It offers the potential to optimize therapeutic outcomes by tailoring treatments to individual genetic profiles. This review explores the central role of pharmacogenomics in addr...
Proceedings of the National Academy of Sciences of the United States of America
Jul 31, 2025
Ocular adnexal lymphoma (OAL) is the most common orbital malignancy in adults. Advanced tools for precise diagnosis and prognosis of OAL are in demand. Here, the nanoparticle-enhanced laser desorption/ionization mass spectrometry was applied for the ...
BACKGROUND: Although the clinical outcome of ER + breast cancer patients receiving tamoxifen after surgery is favorable, a proportion of patients experience recurrence or death due to disease progression.
BACKGROUND: Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Although immune checkpoint inhibitors (ICIs) have brought new treatment options for advanced patients, a considerable proportion still shows limited resp...
DNA damage response (DDR) and crotonylation occur frequently in lung adenocarcinoma (LUAD), but their relationship is yet to be elucidated. RNA sequencing data from LUAD patients in GSE27262 and GSE140797 datasets were obtained. DDR-crotonylation-rel...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jul 29, 2025
Immunotherapy has revolutionized lung cancer treatment, yet predicting patient response remains a challenge. This study used Raman spectroscopy to differentiate between non-small-cell lung cancer patients with short-lasting and long-lasting responses...
The integration of heterogeneous multi-omics datasets at a systems level remains a central challenge for developing analytical and computational models in precision cancer diagnostics. This paper introduces Multi-Omics Graph Kolmogorov-Arnold Network...
The Ki67 score is a crucial prognostic biomarker for neuroendocrine tumors, but its manual assessment is labor-intensive, requiring the counting of 500-2,000 cells in hotspots. Digital image analysis could streamline this process, yet few comprehensi...
DNA methylation is a common epigenetic modification that maintains the integrity of the DNA sequence while profoundly influencing gene expression and phenotypic variation. Aberrant DNA methylation has been associated with the onset and progression of...
International journal of biological macromolecules
Jul 28, 2025
Enzyme-triggered polymersomes have emerged as a transformative platform in liquid biopsy and cancer diagnostics, enabling high-accuracy biomarker detection through precise enzymatic responsiveness. This review comprehensively examines the rational de...
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