AIMC Topic: Biomarkers

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Circulating microRNAs in viral myocarditis: Advancements in biological understanding and potential clinical applications.

Gene
Viral myocarditis (VMC) is a prevalent inflammatory cardiac condition, characterized by highly variable clinical manifestations that present significant challenges for early diagnosis and the development of personalized treatment strategies. Conseque...

A machine learning model including pentraxin-3 as predictor of outcomes in community-acquired pneumonia.

Journal of translational medicine
BACKGROUND: The clinical diagnosis, severity assessment, and outcome prognostication of community-acquired pneumonia (CAP) remain challenging due to the complex disease pathophysiology. Accurate outcome prediction is crucial for optimizing patient ma...

Optic disc morphometrics as a potential ocular biomarker for depression: evidence from two cross-sectional cohort studies.

Translational psychiatry
Depression, which is increasingly prevalent among older adults, has traditionally been diagnosed through symptom-based questionnaires. However, emerging evidence suggests that retinal changes could serve as objective biomarkers for depression. In thi...

Reliable biomarkers for diabetic nephropathy using machine learning-assisted contrast-enhanced ultrasonography and clinical characteristics.

Clinical and experimental medicine
OBJECTIVE: To utilize machine learning techniques to screen contrast-enhanced ultrasound (CEUS) parameters and clinical characteristics, aiming to differentiate diabetic nephropathy (DN) from non-diabetic renal disease (NDRD) in patients with diabeti...

Identification of potential biomarkers for Lyme disease using bioinformatics and machine learning.

Clinical and experimental medicine
Lyme disease (LD) presents significant diagnostic challenges due to the absence of a reliable screening method for initial detection. This study aimed to identify potential biomarkers using bioinformatics and machine learning algorithms, which may co...

Predictive value of systemic inflammation response index for atherosclerotic cardiovascular disease risk in patients with hypercholesterolemia: a machine learning study with dual-cohort validation.

Lipids in health and disease
BACKGROUND: Residual cardiovascular risk persists in patients with hypercholesterolemia despite lipid-lowering therapy, underscoring the importance of inflammation in ASCVD development. This study evaluated the relationship between Systemic Inflammat...

Evaluation of normalized T1 signal intensity obtained using an automated segmentation model in lower leg MRI as a potential imaging biomarker in Charcot-Marie-Tooth disease type 1 A.

Scientific reports
We evaluated the potential utility of imaging parameters derived by normalizing muscle signal intensity on T1-weighted lower leg MRIs in Charcot-Marie-Tooth disease type 1 A (CMT1A) patients, using a deep learning-based automated muscle segmentation ...

Multi-omics and machine learning identify FN1 and ALDH2 as diagnostic biomarkers and therapeutic targets in early and late diabetic kidney disease.

Renal failure
Diabetic kidney disease (DKD), the leading cause of end-stage kidney disease worldwide, demands deeper molecular characterization to improve clinical management. This study employed an integrated multi-omics approach to identify stage-specific biomar...

Comprehensive analysis of metabolic and molecular alterations in the blood of patients with Sjögren's syndrome based on untargeted metabolomics analysis.

BMC medical genomics
BACKGROUND: Sjögren's syndrome (SS) is a chronic autoimmune disorder marked by lymphocytic infiltration of exocrine glands, leading to xerostomia, keratoconjunctivitis sicca, and systemic involvement including fatigue, arthralgia, and visceral organ ...

Identifying EEG-based neurobehavioral risk markers of gaming addiction using machine learning and iowa gambling task.

Biomedical physics & engineering express
Internet Gaming Disorder (IGD), Gaming Disorder (GD), and Internet Addiction represent behavioral patterns with significant psychological and neurological consequences. Affected individuals often disengage from routine activities and exhibit distress...