Deep learning for protein function prediction faces significant challenges in identifying disease-specific proteins. We present Extracellular Matrix Protein Predictor (EPOP), an advanced transfer learning framework leveraging protein language models ...
BACKGROUND: Glaucoma is a progressive neurodegenerative disease of the optic nerve and one of the leading causes of irreversible blindness worldwide. Small RNAs (including miRNAs) play an important role in the pathogenesis of the disease. Despite ext...
BACKGROUND: Primary Sjögren's syndrome (pSS) is an autoimmune and inflammatory disorder that may affect the lungs, leading to interstitial lung disease (ILD). However, the diagnosis of progression from pSS to ILD is frequently delayed due to unstanda...
BACKGROUND: Patients with diabetes admitted to emergency care face a higher risk of complications, including prolonged hospital stays, admissions to the intensive care unit and mortality.
BACKGROUND: Preeclampsia (PE) is a serious hypertensive complication during pregnancy characterized by immune dysregulation and vascular dysfunction, however, the precise molecular mechanisms and effective therapeutic strategies remain unclear. This ...
Polycystic Ovarian Disease (PCOD), also known as Polycystic Ovary Syndrome (PCOS), is a prevalent hormonal and metabolic condition primarily affecting women of reproductive age worldwide. It is typically marked by disrupted ovulation, an increase in ...
Periodontitis, a prevalent inflammatory disease, leads to the progressive destruction of periodontal tissues and poses significant systemic health risks. Despite its widespread impact, the molecular mechanisms driving periodontitis remain poorly unde...
Forensic body fluid identification is crucial for reconstructing crime scene events. While DNA analysis provides individualization, it lacks information about the fluid's origin. We developed and evaluated three complementary proteomic approaches usi...
BACKGROUND: Ulcerative colitis (UC) is a chronic nonspecific inflammatory intestinal disease affecting the mucosa and submucosa, characterized by continuous and diffuse active inflammation. However, its underlying pathogenesis remains unclear.
INTRODUCTION: Quantification of amyloid plaques (A), neurofibrillary tangles (T), and neurodegeneration (N) using PET and MRI is critical for Alzheimer's disease (AD) diagnosis and prognosis. Existing pipelines face limitations regarding processing t...
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