Journal of computational biology : a journal of computational molecular cell biology
Oct 30, 2017
Pathologists often deal with high complexity and sometimes disagreement over osteosarcoma tumor classification due to cellular heterogeneity in the dataset. Segmentation and classification of histology tissue in H&E stained tumor image datasets is a ...
International journal of molecular medicine
Sep 7, 2017
In this study, gene expression profiles of osteosarcoma (OS) were analyzed to identify critical genes associated with metastasis. Five gene expression datasets were screened and downloaded from Gene Expression Omnibus (GEO). Following assessment by M...
INTRODUCTION: The bone scan index (BSI) was introduced as a quantitative tool for tumor involvement in bone of patients with metastatic prostate cancer (mPCa). The computer-aided diagnosis device for BSI analysis EXINIbone seems to represent technica...
International journal of radiation oncology, biology, physics
Nov 17, 2016
PURPOSE: To evaluate C-11 choline positron emission tomography/computed tomography (CholPET) in staging and determining patterns of recurrence in prostate cancer patients with rising prostate-specific antigen levels after prostatectomy radiation ther...
OBJECTIVE: The accuracy of bone scintigraphy analyzed by computer-assisted diagnosis (CAD) software involving multiple artificial neural network (ANN) systems has not been well established.
Osteosarcoma (OS) calls for early diagnosis to significantly improve patient survival rates. Exosomes hold significant potential as noninvasive biomarkers for the early diagnosis of cancer. Here, we design a microfluidic device to purify and analyze ...
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of...
BACKGROUND AND AIMS: Osteosarcoma (OS) is the most common primary bone malignancy, and neoadjuvant chemotherapy (NAC) improves survival rates. However, OS heterogeneity results in variable treatment responses, highlighting the need for reliable, non-...
Distinguishing osteosarcoma from bone callus remains a clinical challenge due to their morphological similarities. This study proposes J-CAN, a multimodal deep learning framework integrating hyperspectral imaging (HSI) and H&E-stained pathology for r...
Computer methods and programs in biomedicine
Jun 1, 2025
BACKGROUND AND OBJECTIVE: Patients with metastatic bone disease are at risk of pathological femoral fractures and may require prophylactic surgical fixation. Current clinical decision support tools often overestimate fracture risk, leading to overtre...
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