AIMC Topic: Carcinoma, Non-Small-Cell Lung

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Comprehensive Analysis of Epigenetic Signatures in Non-Small Cell Lung Cancer: Development and Validation of an Epigenetics-Based Prognostic Model for Drug Sensitivity Prediction.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Non-small cell lung cancer (NSCLC) exhibits complex epigenetic dysregulation that impacts treatment response and prognosis, yet comprehensive analysis linking epigenetic signatures to clinical outcomes remains limited. We integrated single-cell RNA s...

Knowledge-based trade-off prediction for NSCLC treatment planning using multi-output regression.

Medical physics
BACKGROUND: Knowledge-based planning (KBP) is a data-driven approach that utilizes the knowledge from previous high-quality treatment plans to predict dose-volume histogram (DVH) parameters for organs-at-risk (OARs) in new cases. Research has demonst...

External Validation of a CT-Based Radiogenomics Model for the Detection of EGFR Mutation in NSCLC and the Impact of Prevalence in Model Building by Using Synthetic Minority Over Sampling (SMOTE): Lessons Learned.

Academic radiology
RATIONALE AND OBJECTIVES: Radiogenomics holds promise in identifying molecular alterations in nonsmall cell lung cancer (NSCLC) using imaging features. Previously, we developed a radiogenomics model to predict epidermal growth factor receptor (EGFR) ...

A robust machine learning model based on ribosomal-subunit-derived piRNAs for diagnostic potential of nonsmall cell lung cancer across multicentre, large-scale of sequencing data.

Clinical and translational medicine
Nonsmall cell lung cancer (NSCLC) is a lethal cancer and lacks robust biomarkers for noninvasive clinical diagnosis. Detecting NSCLC at the early stage can decrease the mortality rate and minimise harm caused by various treatments. We curated 2050 sa...

Non-invasive CT based multiregional radiomics for predicting pathologic complete response to preoperative neoadjuvant chemoimmunotherapy in non-small cell lung cancer.

European journal of radiology
PURPOSE: This study aims to develop and validate a multiregional radiomics model to predict pathological complete response (pCR) to neoadjuvant chemoimmunotherapy in non-small cell lung cancer (NSCLC), and further evaluate the performance of the mode...

Development and Validation of a Machine Learning-Based Predictive Model for Postoperative Frailty in Patients with Non-Small Cell Lung Cancer and Its Relation to Early Recovery.

Annals of surgical oncology
PURPOSE: This study was designed to evaluate the postoperative frailty status of patients with non-small cell lung cancer, identify influencing factors, establish a machine learning-based prediction model, and explore the correlation between frailty ...

Application of Fourier transform infrared (FTIR) spectroscopy in liquid biopsy to predict the response to the first-line immunotherapy in non-small-cell lung cancer (NSCLC) patients.

Biochemical and biophysical research communications
The direction of anticancer therapies has changed in recent years, including the increasing use of immunotherapy. However, around 50 % of non-small-cell lung cancer (NSCLC) patients do not respond to immunotherapy. Therefore, it is important to find ...

Trustworthy AI for stage IV non-small cell lung cancer: Automatic segmentation and uncertainty quantification.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Accurate segmentation of lung tumors is essential for advancing personalized medicine in non-small cell lung cancer (NSCLC). However, stage IV NSCLC presents significant challenges due to heterogeneous tumor morphology and the presence of associated ...

Evaluating an information theoretic approach for selecting multimodal data fusion methods.

Journal of biomedical informatics
OBJECTIVE: Interest has grown in combining radiology, pathology, genomic, and clinical data to improve the accuracy of diagnostic and prognostic predictions toward precision health. However, most existing works choose their datasets and modeling appr...