The intrinsic complexity of biological processes often hides the role of dynamic microenvironmental cues in the development of pathological states. Microphysiological systems (MPSs) are emerging technological platforms that model dynamics of tissue-...
Immunogenic cell death (ICD) can enhance the immunogenicity of cold tumors, convert them into immune-responsive hot tumors, and improve the efficacy of cancer immunotherapy. Because ICD inducers cause cell swelling, membrane rupture, and the release ...
Ecotoxicology and environmental safety
Jul 22, 2025
BACKGROUND: Breast cancer (BRCA) is the most common malignancy in women worldwide. Selenium (Se), a crucial trace element, significantly impacts BRCA patient survival, although its roles in tumorigenesis, the tumor immune microenvironment (TIME), and...
The tumor microenvironment plays a critical role in tumor progression and immune response, with the extracellular matrix (ECM) regulating immune cell infiltration. However, the interplay between ECM dynamics and tumor immunity remains poorly understo...
BACKGROUND: Ferroptosis and disulfidptosis are newly discovered forms of regulated cell death that play critical roles in cancer progression, metabolism, and immune evasion. However, their interplay and combined influence on colorectal cancer (CRC) p...
PURPOSE: Colorectal cancer is a highly aggressive malignancy characterized by complex tumor micro-environments and significant drug resistance. We highlighted the critical role of curcumin in inhibiting tumor growth and migration, inducing cuproptosi...
Disturbances in transcriptional regulation during hematopoiesis can lead to aberrant hematopoietic differentiation and potential leukemogenesis. Given the high relapse risk of acute myeloid leukemia (AML), understanding its progression mechanisms and...
Monitoring cellular spatiotemporal dynamics is essential for understanding complex biological processes such as organ development and cancer progression. Using live-cell fluorescence microscopy to track cellular dynamics is often limited by dye-induc...
Journal of molecular neuroscience : MN
Jul 16, 2025
DNA methylation plays a crucial role in the onset and progression of Alzheimer's disease (AD). Genome-wide methylation analysis of multi-tissue data can provide insights into the pathology and diagnostic biomarkers of AD. Computational tools were emp...
Mathematical models are conventionally used to understand the of tumor behaviors, but they generally lack in precisely correlating drug efficacy with tumor response. Artificial intelligence (AI) has forged a new avenue in cancer management, but requi...
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