Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially expressed genes, and appl...
Journal of agricultural and food chemistry
Sep 16, 2025
Glabridin (GLA), a characteristic polyphenolic extracted from the renowned sweet plant L., demonstrates potent anticancer effects. This study aims to investigate the effects of GLA on triple-negative breast cancer (TNBC) and its underlying mechanisms...
Endoplasmic reticulum (ER) stress and its associated unfolded protein response (UPR) have been demonstrated to play a crucial role in cancer's progression, but their prognostic significance in breast cancer (BC) remains unclear. In this study, a reli...
Immunogenic cell death (ICD) is capable of activating both innate and adaptive immune responses. In this study, we aimed to develop an ICD-related signature in glioma patients and facilitate the assessment of their prognosis and drug sensitivity. Con...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Aug 7, 2025
BET inhibitor is a novel strategy in tumor therapy based on targeting epigenetic mechanism. In recent decades, dozens of clinical trials have been conducted to validate the potential efficacy of the first-generation BET inhibitors in refractory cance...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Aug 2, 2025
Despite therapeutic advancements, metastatic and nonmetastatic castration-resistant prostate cancer (mCRPC and nmCRPC) remain incurable due to drug resistance, partly due to Androgen receptor (AR) gene abnormalities and splice variants. An Augmented ...
Papillary thyroid carcinoma (PTC) is the main pathological subtype of thyroid cancer. Given the strong association between T cells and PTC, this study focused on the prognostic value and potential molecular mechanisms of T cell proliferation-related ...
The intrinsic complexity of biological processes often hides the role of dynamic microenvironmental cues in the development of pathological states. Microphysiological systems (MPSs) are emerging technological platforms that model dynamics of tissue-...
PURPOSE: Colorectal cancer is a highly aggressive malignancy characterized by complex tumor micro-environments and significant drug resistance. We highlighted the critical role of curcumin in inhibiting tumor growth and migration, inducing cuproptosi...
Monitoring cellular spatiotemporal dynamics is essential for understanding complex biological processes such as organ development and cancer progression. Using live-cell fluorescence microscopy to track cellular dynamics is often limited by dye-induc...
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