ETHNOPHARMACOLOGICAL RELEVANCE: Erzhi Pill (EZP), a traditional Chinese medicine used for various cancers, exhibits antitumor potential, though its role and mechanisms in Triple-Negative Breast Cancer (TNBC) remain unclear.
Hepatocellular carcinoma (HCC) progression and prognosis are influenced by various molecular markers. This study aimed to identify the hub gene associated with HCC clinical characteristics and its role in HCC progression. Differentially expressed gen...
Cell communication and signaling : CCS
Jul 8, 2025
Characterized by high malignancy and limited treatment efficacy, triple-negative breast cancer (TNBC) remains a clinically challenging subtype within breast cancer classifications, marked by rapid progression and high mortality. Abnormal activation o...
High-throughput screening for inhibitors of protein-protein interactions (PPIs) provides vital information for therapeutic intervention in diseases driven by aberrant PPIs. Traditionally, the discovery of PPI inhibitors involves sequential steps: in ...
Phytomedicine : international journal of phytotherapy and phytopharmacology
Jul 6, 2025
BACKGROUND: Lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) is a major contributor to poor prognosis. Prunella vulgaris (P. vulgaris), a traditional medicinal herb, has shown potential in inhibiting PTC metastasis, but its molecular ...
Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into question whether and how new neurons may be generated...
This study aims to determine the optimum extraction conditions that maximize the biological activities of Agaricus campestris and Agaricus bisporus species. In the study, a total of 64 extraction experiments were carried out at different temperatures...
In the field of cancer therapy, the diversity and heterogeneity of cancer genomes in clinical patients complicate and challenge the effective use of non-targeted drugs, as these drugs often fail to address specific genetic events. Recent advancements...
Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide, posing a significant threat to the life and health of people globally. LKB1-AMPK signaling pathway plays a significant role in the regulation of cellular metabolism, prolifera...
Cancer-associated fibroblasts (CAFs) play important roles in the progression of lung adenocarcinoma (LUAD). We examined CAF subgroups via gene ontology, pseudo-time, and cell communication analyses and explored their prognostic value in LUAD using a ...
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