AIMC Topic: Chemotherapy, Adjuvant

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Machine learning with multiparametric magnetic resonance imaging of the breast for early prediction of response to neoadjuvant chemotherapy.

Breast (Edinburgh, Scotland) Nov 23, 2019
In patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy (NAC), some patients achieve a complete pathologic response (pCR), some achieve a partial response, and some do not respond at all or even progress. Accurate predicti...
Humans Treatment Outcome Neoadjuvant Therapy Predictive Value of Tests Breast Chemotherapy, Adjuvant Multiparametric Magnetic Resonance Imaging Machine Learning Female Adult Breast Neoplasms Middle Aged
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[Prediction of chemotherapy response in primary osteosarcoma using the machine learning technique on radiomic data].

Bulletin du cancer Oct 3, 2019
INTRODUCTION: Osteosarcoma is the most common malignant bone tumor before 25 years of age. Response to neoadjuvant chemotherapy determines continuation of treatment and is also a powerful prognostic factor. There are currently no reliable ways to eva...
Bone Neoplasms Predictive Value of Tests France Analysis of Variance Chemotherapy, Adjuvant Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Neoadjuvant Therapy Magnetic Resonance Imaging Osteosarcoma Machine Learning Retrospective Studies Female Infant, Newborn Young Adult Sensitivity and Specificity Male Infant Adolescent Child, Preschool Child Humans
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Robust identification of molecular phenotypes using semi-supervised learning.

BMC bioinformatics May 28, 2019
BACKGROUND: Modern molecular profiling techniques are yielding vast amounts of data from patient samples that could be utilized with machine learning methods to provide important biological insights and improvements in patient outcomes. Unsupervised ...
Humans Algorithms Phenotype Lymphoma Supervised Machine Learning Prognosis Disease-Free Survival Female Databases as Topic Breast Neoplasms Chemotherapy, Adjuvant RNA, Messenger Gene Expression Regulation, Neoplastic
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Combining multimodal imaging and treatment features improves machine learning-based prognostic assessment in patients with glioblastoma multiforme.

Cancer medicine Dec 18, 2018
BACKGROUND: For Glioblastoma (GBM), various prognostic nomograms have been proposed. This study aims to evaluate machine learning models to predict patients' overall survival (OS) and progression-free survival (PFS) on the basis of clinical, patholog...
Aged Aged, 80 and over Young Adult Adult Brain Neoplasms Male Humans Machine Learning Prognosis Female Positron Emission Tomography Computed Tomography Survival Analysis Chemotherapy, Adjuvant Middle Aged Models, Theoretical Magnetic Resonance Imaging Multimodal Imaging Glioblastoma
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Prediction of postoperative disease-free survival and brain metastasis for HER2-positive breast cancer patients treated with neoadjuvant chemotherapy plus trastuzumab using a machine learning algorithm.

Breast cancer research and treatment Sep 7, 2018
PURPOSE: This study aimed to develop mathematical tools to predict the likelihood of recurrence after neoadjuvant chemotherapy (NAC) plus trastuzumab in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer.
Chemotherapy, Adjuvant Retrospective Studies Female Aged Adult Breast Neoplasms Brain Neoplasms Middle Aged Models, Theoretical Disease-Free Survival Receptor, ErbB-2 Trastuzumab Humans Machine Learning
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Immunomarker Support Vector Machine Classifier for Prediction of Gastric Cancer Survival and Adjuvant Chemotherapeutic Benefit.

Clinical cancer research : an official journal of the American Association for Cancer Research Jul 24, 2018
Current tumor-node-metastasis (TNM) staging system cannot provide adequate information for prediction of prognosis and chemotherapeutic benefits. We constructed a classifier to predict prognosis and identify a subset of patients who can benefit from...
Female Aged Stomach Neoplasms Biomarkers, Tumor Male Middle Aged ROC Curve Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Support Vector Machine Neoplasm Staging Humans Prognosis Neoplasm Grading Survival Analysis Tumor Burden Immunohistochemistry Chemotherapy, Adjuvant
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Predicting Post Neoadjuvant Axillary Response Using a Novel Convolutional Neural Network Algorithm.

Annals of surgical oncology Jul 5, 2018
OBJECTIVES: In the postneoadjuvant chemotherapy (NAC) setting, conventional radiographic complete response (rCR) is a poor predictor of pathologic complete response (pCR) of the axilla. We developed a convolutional neural network (CNN) algorithm to b...
Carcinoma, Ductal, Breast Receptors, Estrogen Chemotherapy, Adjuvant Carcinoma, Lobular Follow-Up Studies Magnetic Resonance Imaging Neoplasm Invasiveness Axilla Receptor, ErbB-2 Aged Aged, 80 and over Young Adult Adult Survival Rate Humans Breast Neoplasms Neural Networks, Computer Biomarkers, Tumor Algorithms Middle Aged Prognosis ROC Curve Retrospective Studies Antineoplastic Combined Chemotherapy Protocols Female Neoadjuvant Therapy
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Prediction of Overall Survival and Novel Classification of Patients with Gastric Cancer Using the Survival Recurrent Network.

Annals of surgical oncology Mar 1, 2018
BACKGROUND: Artificial neural networks (ANNs) have been applied to many prediction and classification problems, and could also be used to develop a prediction model of survival outcomes for cancer patients.
Models, Biological Gastrectomy Kaplan-Meier Estimate Chemotherapy, Adjuvant Male Middle Aged ROC Curve Area Under Curve Neoplasm Staging Neural Networks, Computer Forecasting Female Humans Aged Stomach Neoplasms Survival Rate
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Optimal adjuvant endocrine treatment of ER+/HER2+ breast cancer patients by age at diagnosis: A population-based cohort study.

European journal of cancer (Oxford, England : 1990) Dec 21, 2017
BACKGROUND: Prior randomised controlled trials on adjuvant hormonal therapy included HER2 patients; however, a differential effect of aromatase inhibitors (AIs) versus tamoxifen (TAM) may have been missed in ER+/HER2+ patients that comprise 7-15% of ...
Netherlands Age of Onset Receptor, ErbB-2 Proportional Hazards Models Aromatase Inhibitors Kaplan-Meier Estimate Receptors, Estrogen Adult Humans Antineoplastic Agents, Hormonal Breast Neoplasms Female Chemotherapy, Adjuvant Middle Aged Tamoxifen Cohort Studies Disease-Free Survival Aged
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Rate and association of lower urinary tract infection with recurrence after transurethral resection of bladder tumor.

Investigative and clinical urology Dec 15, 2017
PURPOSE: To evaluate the rate of pyuria and bacteriuria after transurethral resection of bladder tumor (TURBT).
Follow-Up Studies Urinary Bladder Neoplasms Aged, 80 and over Humans Bacteriuria Male Retrospective Studies Urinary Tract Infections Administration, Intravesical Middle Aged Female Neoplasm Recurrence, Local Chemotherapy, Adjuvant Postoperative Complications Risk Factors Pyuria Antineoplastic Agents Aged
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