AIMC Topic: Chemotherapy, Adjuvant

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Immunomarker Support Vector Machine Classifier for Prediction of Gastric Cancer Survival and Adjuvant Chemotherapeutic Benefit.

Clinical cancer research : an official journal of the American Association for Cancer Research Jul 24, 2018
Current tumor-node-metastasis (TNM) staging system cannot provide adequate information for prediction of prognosis and chemotherapeutic benefits. We constructed a classifier to predict prognosis and identify a subset of patients who can benefit from...
Humans Prognosis Neoplasm Staging Neoplasm Grading Survival Analysis Tumor Burden Immunohistochemistry Female Middle Aged Chemotherapy, Adjuvant Aged ROC Curve Stomach Neoplasms Antineoplastic Combined Chemotherapy Protocols Biomarkers, Tumor Treatment Outcome Male Support Vector Machine
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Predicting Post Neoadjuvant Axillary Response Using a Novel Convolutional Neural Network Algorithm.

Annals of surgical oncology Jul 5, 2018
OBJECTIVES: In the postneoadjuvant chemotherapy (NAC) setting, conventional radiographic complete response (rCR) is a poor predictor of pathologic complete response (pCR) of the axilla. We developed a convolutional neural network (CNN) algorithm to b...
Survival Rate Breast Neoplasms Biomarkers, Tumor Middle Aged Humans ROC Curve Neural Networks, Computer Female Algorithms Prognosis Aged Retrospective Studies Axilla Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols Receptor, ErbB-2 Young Adult Neoadjuvant Therapy Carcinoma, Ductal, Breast Adult Follow-Up Studies Receptors, Estrogen Magnetic Resonance Imaging Chemotherapy, Adjuvant Neoplasm Invasiveness Carcinoma, Lobular
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Prediction of Overall Survival and Novel Classification of Patients with Gastric Cancer Using the Survival Recurrent Network.

Annals of surgical oncology Mar 1, 2018
BACKGROUND: Artificial neural networks (ANNs) have been applied to many prediction and classification problems, and could also be used to develop a prediction model of survival outcomes for cancer patients.
Forecasting Female Aged Stomach Neoplasms Survival Rate Humans Neural Networks, Computer Models, Biological Gastrectomy Kaplan-Meier Estimate Chemotherapy, Adjuvant Male Middle Aged ROC Curve Area Under Curve Neoplasm Staging
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Optimal adjuvant endocrine treatment of ER+/HER2+ breast cancer patients by age at diagnosis: A population-based cohort study.

European journal of cancer (Oxford, England : 1990) Dec 21, 2017
BACKGROUND: Prior randomised controlled trials on adjuvant hormonal therapy included HER2 patients; however, a differential effect of aromatase inhibitors (AIs) versus tamoxifen (TAM) may have been missed in ER+/HER2+ patients that comprise 7-15% of ...
Netherlands Humans Age of Onset Female Kaplan-Meier Estimate Adult Receptor, ErbB-2 Aged Receptors, Estrogen Breast Neoplasms Proportional Hazards Models Antineoplastic Agents, Hormonal Middle Aged Aromatase Inhibitors Chemotherapy, Adjuvant Cohort Studies Tamoxifen Disease-Free Survival
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Rate and association of lower urinary tract infection with recurrence after transurethral resection of bladder tumor.

Investigative and clinical urology Dec 15, 2017
PURPOSE: To evaluate the rate of pyuria and bacteriuria after transurethral resection of bladder tumor (TURBT).
Follow-Up Studies Aged, 80 and over Administration, Intravesical Urinary Bladder Neoplasms Male Chemotherapy, Adjuvant Bacteriuria Middle Aged Humans Pyuria Urinary Tract Infections Postoperative Complications Neoplasm Recurrence, Local Retrospective Studies Antineoplastic Agents Female Risk Factors Aged
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Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer drug therapies: a machine learning approach.

BMC cancer Dec 1, 2016
BACKGROUND: Multidisciplinary team (MDT) meetings are used to optimise expert decision-making about treatment options, but such expertise is not digitally transferable between centres. To help standardise medical decision-making, we developed a machi...
Supervised Machine Learning Chemotherapy, Adjuvant Patient Care Team Computer Simulation Clinical Decision-Making Female Aged Aged, 80 and over Adult Breast Neoplasms Middle Aged Models, Theoretical Humans Antineoplastic Combined Chemotherapy Protocols Machine Learning Combined Modality Therapy Algorithms
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Cancer Care Access and Outcomes for American Indian Populations in the United States: Challenges and Models for Progress.

Seminars in radiation oncology Nov 24, 2016
Low socioeconomic and health care access realities of being American Indian/Alaskan Native (AI/AN) in the United States combined with decades of data documenting poor cancer outcomes for this population provide a population nested within the United S...
Radiotherapy Chemotherapy, Adjuvant Humans Neoplasms United States Health Services Accessibility Indians, North American Alaska Natives
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SNRFCB: sub-network based random forest classifier for predicting chemotherapy benefit on survival for cancer treatment.

Molecular bioSystems Feb 11, 2016
Adjuvant chemotherapy (CTX) should be individualized to provide potential survival benefit and avoid potential harm to cancer patients. Our goal was to establish a computational approach for making personalized estimates of the survival benefit from ...
Kaplan-Meier Estimate Chemotherapy, Adjuvant Humans Computational Biology Neural Networks, Computer Treatment Outcome Machine Learning Support Vector Machine Prognosis Models, Statistical Female Reproducibility of Results Area Under Curve Breast Neoplasms Male Neoplasms Antineoplastic Agents Lung Neoplasms
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Adjuvant Carboplatin Treatment in 115 Patients With Stage I Seminoma: Retrospective Multicenter Survey.

Clinical genitourinary cancer Dec 17, 2015
BACKGROUND: The administration of carboplatin AUC 7 has become a standard adjuvant option for patients undergoing orchiectomy for stage I seminoma, in alternative to radiotherapy on retroperitoneal lymphnodes or surveillance. The toxicity of AUC 7 ca...
Testicular Neoplasms Seminoma Dose-Response Relationship, Drug Italy Carboplatin Chemotherapy, Adjuvant Adult Male Middle Aged Antineoplastic Agents Treatment Outcome Humans Retrospective Studies Young Adult
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Postoperative photodynamic therapy as a new adjuvant treatment after robot-assisted salvage surgery of recurrent squamous cell carcinoma of the base of tongue.

World journal of surgical oncology Jul 16, 2015
BACKGROUND: For patients who remain with involved resection margins after transoral robot-assisted salvage surgery (TORS) for recurrent squamous cell carcinoma (SCC) at the base of tongue (BOT) following primary (chemo)radiotherapy, further adjuvant ...
Humans Prognosis Female Carcinoma, Squamous Cell Male Tongue Neoplasms Middle Aged Photochemotherapy Antineoplastic Combined Chemotherapy Protocols Salvage Therapy Robotics Postoperative Period Neoplasm Staging Chemotherapy, Adjuvant Neoplasm Recurrence, Local
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