AIMC Topic: Depressive Disorder, Major

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Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study.

Translational psychiatry
Previous studies have found that major depressive disorder (MDD) may accelerate overall structural brain aging. Nevertheless, it still remains unknown whether anhedonia, a critical negative prognostic indicator in MDD, further leads to advanced brain...

Data-driven cognitive subtypes in major depressive disorder: Grey matter atrophy in the left fusiform gyrus and cerebellum.

Journal of affective disorders
BACKGROUND: This study aims to apply a semi-supervised machine learning approach for classifying major depressive disorder (MDD) patients into more homogeneous cognitive subtypes based on multidimensional cognitive profiles, and to perform multimodal...

Recent developments in omics studies and artificial intelligence in depression and suicide.

Translational psychiatry
Major depressive disorder (MDD) is the most prevalent and severe form of mental illness and is significantly linked to suicide. At present, addressing the treatment and prevention of depression and suicide poses significant challenges, largely due to...

FGDN: A Federated Graph Convolutional Network framework for multi-site major depression disorder diagnosis.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
The vast amount of healthcare data is characterized by its diversity, dynamic nature, and large scale. It is a challenge that directly training a Graph Convolutional Neural Network (GCN) in a multi-site dataset poses to protecting the privacy of Majo...

Dynamic neural network modulation associated with rumination in major depressive disorder: a prospective observational comparative analysis of cognitive behavioral therapy and pharmacotherapy.

Translational psychiatry
Cognitive behavioral therapy (CBT) and pharmacotherapy are primary treatments for major depressive disorder (MDD). However, their differential effects on the neural networks associated with rumination, or repetitive negative thinking, remain poorly u...

Altered effective connectivity in patients with drug-naïve first-episode, recurrent, and medicated major depressive disorder: A multi-site fMRI study.

Behavioural brain research
BACKGROUND: Major depressive disorder (MDD) has been diagnosed through subjective and inconsistent clinical assessments. Resting-state functional magnetic resonance imaging (rs-fMRI) with connectivity analysis has been valuable for identifying neural...

Leveraging stacked classifiers for exploring the role of hedonic processing between major depressive disorder and schizophrenia.

Psychological medicine
BACKGROUND: Anhedonia, a transdiagnostic feature common to both Major Depressive Disorder (MDD) and Schizophrenia (SCZ), is characterized by abnormalities in hedonic experience. Previous studies have used machine learning (ML) algorithms without focu...

Uncertainty aware domain incremental learning for cross domain depression detection.

Scientific reports
Deep learning techniques have demonstrated significant promise for detecting Major Depressive Disorder (MDD) from textual data but they still face limitations in real-world scenarios. Specifically, given the limited data availability, some efforts ha...

Decoding depression: Event related potential dynamics and predictive neural signatures of depression severity.

Journal of affective disorders
Depression is a heterogeneous disorder marked by disruptions in cognitive and affective processing. While self-reported measures and clinical interviews remain the diagnostic standard, integrating objective neurophysiological markers could enhance as...

Detecting schizophrenia, bipolar disorder, psychosis vulnerability and major depressive disorder from 5 minutes of online-collected speech.

Translational psychiatry
Psychosis poses substantial social and healthcare burdens. The analysis of speech is a promising approach for the diagnosis and monitoring of psychosis, capturing symptoms like thought disorder and flattened affect. Recent advancements in Natural Lan...