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Diabetes Mellitus, Type 2

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Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.

Frontiers in immunology
BACKGROUND: Type 2 Diabetes Mellitus (T2DM) represents a major global health challenge, marked by chronic hyperglycemia, insulin resistance, and immune system dysfunction. Immune cells, including T cells and monocytes, play a pivotal role in driving ...

Using a robust model to detect the association between anthropometric factors and T2DM: machine learning approaches.

BMC medical informatics and decision making
BACKGROUND: The aim of this study was to evaluate the potential models to determine the most important anthropometric factors associated with type 2 diabetes mellitus (T2DM).

Deep learning based prediction of depression and anxiety in patients with type 2 diabetes mellitus using regional electronic health records.

International journal of medical informatics
BACKGROUND: Depression and anxiety are prevalent mental health conditions among individuals with type 2 diabetes mellitus (T2DM), who exhibit unique vulnerabilities and etiologies. However, existing approaches fail to fully utilize regional heterogen...

Machine learning-driven Raman spectroscopy: A novel approach to lipid profiling in diabetic kidney disease.

Nanomedicine : nanotechnology, biology, and medicine
Diabetes mellitus is a chronic metabolic disease that increasingly affects people every year. It is known that with its progression and poor management, metabolic changes can lead to organ dysfunctions, including kidneys. The study aimed to combine R...

Nutritional intake of micronutrient and macronutrient and type 2 diabetes: machine learning schemes.

Journal of health, population, and nutrition
BACKGROUND: Diabetes mellitus, an endocrine system disease, is a common disease involving many patients worldwide. Many studies are performed to evaluate the correlation between micronutrients/macronutrients on diabetes but few of them have a high st...

Predicting cardiovascular outcomes in Chinese patients with type 2 diabetes by combining risk factor trajectories and machine learning algorithm: a cohort study.

Cardiovascular diabetology
BACKGROUND: Cardiovascular complications are major concerns for Chinese patients with type 2 diabetes. Accurately predicting these risks remains challenging due to limitations in traditional risk models. We aimed to develop a dynamic prediction model...

Cross-sectional design and protocol for Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI).

BMJ open
INTRODUCTION: Artificial Intelligence Ready and Equitable for Diabetes Insights (AI-READI) is a data collection project on type 2 diabetes mellitus (T2DM) to facilitate the widespread use of artificial intelligence and machine learning (AI/ML) approa...

REMED-T2D: A robust ensemble learning model for early detection of type 2 diabetes using healthcare dataset.

Computers in biology and medicine
Early diagnosis and timely treatment of diabetes are critical for effective disease management and the prevention of complications. Undiagnosed diabetes can lead to an increased risk of several health issues. Although numerous machine learning (ML) m...

Non-Linear Dose-Response Relationship for Metformin in Japanese Patients With Type 2 Diabetes: Analysis of Irregular Longitudinal Data by Interpretable Machine Learning Models.

Pharmacology research & perspectives
The dose-response relationship between metformin and change in hemoglobin A1c (HbA1c) shows a maximum at 1500-2000 mg/day in patients with type 2 diabetes (T2D) in the U.S. In Japan, there is little evidence on the HbA1c-lowering effect of high-dose ...

A mechanism-informed deep neural network enables prioritization of regulators that drive cell state transitions.

Nature communications
Cells are regulated at multiple levels, from regulations of individual genes to interactions across multiple genes. Some recent neural network models can connect molecular changes to cellular phenotypes, but their design lacks modeling of regulatory ...