AIMC Topic: Disease Models, Animal

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5G ultra-remote robot-assisted laparoscopic surgery in China.

Surgical endoscopy Jul 22, 2020
BACKGROUND: 5G communication technology has been applied to several fields in telemedicine, but its effectiveness, safety, and stability in remote laparoscopic telesurgery have not been established. Here, we conducted four ultra-remote laparoscopic s...
Nephrectomy Intraoperative Complications Wireless Technology Cholecystectomy Robotic Surgical Procedures Telemedicine Hepatectomy Cystectomy Animals Swine China Treatment Outcome Blood Loss, Surgical Disease Models, Animal Robotics Laparoscopy
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Machine learning-based segmentation of ischemic penumbra by using diffusion tensor metrics in a rat model.

Journal of biomedical science Jul 15, 2020
BACKGROUND: Recent trials have shown promise in intra-arterial thrombectomy after the first 6-24 h of stroke onset. Quick and precise identification of the salvageable tissue is essential for successful stroke management. In this study, we examined t...
Machine Learning Rats, Sprague-Dawley Disease Models, Animal Infarction, Middle Cerebral Artery Ischemia Diffusion Tensor Imaging Algorithms Animals Male ROC Curve Rats
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Utilization of a Deep Learning Algorithm for Microscope-Based Fatty Vacuole Quantification in a Fatty Liver Model in Mice.

Toxicologic pathology Jun 8, 2020
Quantification of fatty vacuoles in the liver, with differentiation from lumina of liver blood vessels and bile ducts, is an example where the traditional semiquantitative pathology assessment can be enhanced with artificial intelligence (AI) algorit...
Artificial Intelligence Image Interpretation, Computer-Assisted Vacuoles Machine Learning Algorithms Animals Deep Learning Mice Disease Models, Animal Liver Non-alcoholic Fatty Liver Disease Microscopy
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Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes.

Pharmacological research May 25, 2020
Xiaokewan is a typical Traditional Chinese medicine (TCM) for diabetes and contains various natural chemicals, such as lignans, flavonoids, saponins, polysaccharides, and western medicine glibenclamide. In the current study, a highly efficient system...
Animals, Genetically Modified Diabetes Mellitus Disease Models, Animal Drugs, Chinese Herbal Workflow Artificial Intelligence Zebrafish Chromatography, High Pressure Liquid Tandem Mass Spectrometry Data Mining Spectrometry, Mass, Electrospray Ionization Protein Interaction Maps Gene Regulatory Networks Systems Biology Rats, Wistar Hypoglycemic Agents Biomarkers Animals Male Blood Glucose
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AxoNet: A deep learning-based tool to count retinal ganglion cell axons.

Scientific reports May 15, 2020
In this work, we develop a robust, extensible tool to automatically and accurately count retinal ganglion cell axons in optic nerve (ON) tissue images from various animal models of glaucoma. We adapted deep learning to regress pixelwise axon count de...
Female Reproducibility of Results Animals Male Deep Learning Glaucoma Software Algorithms Axons Retinal Ganglion Cells Optic Nerve Diseases Disease Susceptibility Computational Biology Rats Disease Models, Animal Optic Nerve Models, Biological
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Enabling pregnant women and their physicians to make informed medication decisions using artificial intelligence.

Journal of pharmacokinetics and pharmacodynamics Apr 11, 2020
The role of artificial intelligence (AI) in healthcare for pregnant women. To assess the role of AI in women's health, discover gaps, and discuss the future of AI in maternal health. A systematic review of English articles using EMBASE, PubMed, and S...
Disease Models, Animal Maternal Health Drug-Related Side Effects and Adverse Reactions Pharmacovigilance Physicians Humans Pregnancy Complications Decision Making, Shared Pregnancy Perinatal Care Machine Learning Female Maternal-Fetal Exchange Animals Preconception Care Prenatal Care
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Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington's disease mice.

BMC bioinformatics Feb 24, 2020
BACKGROUND: MicroRNA (miRNA) regulation is associated with several diseases, including neurodegenerative diseases. Several approaches can be used for modeling miRNA regulation. However, their precision may be limited for analyzing multidimensional da...
RNA-Seq Mice RNA, Messenger Proteomics Disease Models, Animal MicroRNAs Neurons Gene Expression Regulation Trinucleotide Repeats Huntington Disease Humans Machine Learning Brain Animals Huntingtin Protein Gene Knock-In Techniques
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Harnessing big 'omics' data and AI for drug discovery in hepatocellular carcinoma.

Nature reviews. Gastroenterology & hepatology Jan 3, 2020
Hepatocellular carcinoma (HCC) is the most common form of primary adult liver cancer. After nearly a decade with sorafenib as the only approved treatment, multiple new agents have demonstrated efficacy in clinical trials, including the targeted thera...
Molecular Targeted Therapy Carcinoma, Hepatocellular Genomics Disease Models, Animal Translational Research, Biomedical Animals Humans Drug Discovery Artificial Intelligence Antineoplastic Agents Machine Learning Cell Line, Tumor Biomarkers Liver Neoplasms Precision Medicine
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Deep learning enables pathologist-like scoring of NASH models.

Scientific reports Dec 5, 2019
Non-alcoholic fatty liver disease (NAFLD) and the progressive form of non-alcoholic steatohepatitis (NASH) are diseases of major importance with a high unmet medical need. Efficacy studies on novel compounds to treat NAFLD/NASH using disease models a...
Biopsy Humans Feasibility Studies Animals Non-alcoholic Fatty Liver Disease Mice Severity of Illness Index Microscopy Rats Deep Learning Datasets as Topic Disease Models, Animal Image Processing, Computer-Assisted Liver
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Data-driven analyses of motor impairments in animal models of neurological disorders.

PLoS biology Nov 21, 2019
Behavior provides important insights into neuronal processes. For example, analysis of reaching movements can give a reliable indication of the degree of impairment in neurological disorders such as stroke, Parkinson disease, or Huntington disease. T...
Movement Rats Neural Networks, Computer Motor Activity Disease Models, Animal Motor Disorders Stroke Animals Forelimb Nervous System Diseases Male Motor Skills Image Processing, Computer-Assisted
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