AIMC Topic: Disease Models, Animal

Clear Filters Showing 41 to 50 of 328 articles

Robot-Assisted Stereotactic Microinjection Method for Precision Cell Transplantation in Rat and Canine Models.

Cell transplantation Mar 18, 2025
Cell transplantation is a promising approach for addressing neurodegenerative conditions. In this study, we developed a robot-assisted stereotactic microinjection system for transplanting cells. We evaluated the factors that affect cellular graft via...
Disease Models, Animal Robotics Dogs Stereotaxic Techniques Animals Male Cell Transplantation Rats Microinjections Rats, Sprague-Dawley
View on PubMed DOI

Involvement of disulfidptosis in the pathophysiology of autism spectrum disorder.

Life sciences Mar 5, 2025
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, with oxidative stress recognized as a key pathogenic mechanisms. Oxidative stress disrupts intracellular dynamic- thiol/disulfide homeostasis (DTDH), potentially leading to disu...
Mice Disease Models, Animal Disulfides Child Autism Spectrum Disorder Disulfidptosis Humans Female Oxidative Stress Animals Gene Regulatory Networks Male
View on PubMed DOI

Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke.

ACS nano Mar 5, 2025
Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the cl...
Mice Nanoparticles RNA, Small Interfering Disease Models, Animal Mice, Inbred C57BL Infrared Rays Ischemic Stroke Blood-Brain Barrier NLR Family, Pyrin Domain-Containing 3 Protein Animals Infarction, Middle Cerebral Artery Male Deep Learning
View on PubMed DOI

Identification of ALDH2 as a novel target for the treatment of acute kidney injury in kidney transplantation based on WGCNA and machine learning algorithms and exploration of its potential mechanism of action using animal experiments.

Frontiers in immunology Mar 4, 2025
BACKGROUND: Acute kidney injury (AKI) after kidney transplantation is one of the main causes of graft loss and poor patient prognosis, and it is important to explore new targets for treating AKI in kidney transplantation.
Gene Expression Profiling Gene Regulatory Networks Computational Biology Rats Disease Models, Animal Aldehyde Dehydrogenase, Mitochondrial Kidney Transplantation Humans Acute Kidney Injury Machine Learning Animals Algorithms Male
View on PubMed DOI

Resveratrol in animal models of pancreatitis and pancreatic cancer: A systematic review with machine learning.

Phytomedicine : international journal of phytotherapy and phytopharmacology Feb 23, 2025
BACKGROUND: Resveratrol (RES), a common type of plant polyphenols, has demonstrated promising therapeutic efficacy and safety in animal models of pancreatitis and pancreatic cancer. However, a comprehensive analysis of these data is currently unavail...
Humans Machine Learning Animals Pancreatic Neoplasms Antioxidants Pancreatitis Disease Models, Animal Resveratrol
View on PubMed DOI

Deep Learning-Based Tumor Segmentation of Murine Magnetic Resonance Images of Prostate Cancer Patient-Derived Xenografts.

Tomography (Ann Arbor, Mich.) Feb 22, 2025
BACKGROUND/OBJECTIVE: Longitudinal in vivo studies of murine xenograft models are widely utilized in oncology to study cancer biology and develop therapies. Magnetic resonance imaging (MRI) of these tumors is an invaluable tool for monitoring tumor g...
Tibia Heterografts Magnetic Resonance Imaging Algorithms Disease Models, Animal Animals Liver Humans Male Prostatic Neoplasms Deep Learning Image Processing, Computer-Assisted Mice Kidney
View on PubMed DOI

Machine learning-based characterization of PANoptosis-related biomarkers and immune infiltration in ulcerative colitis: A comprehensive bioinformatics analysis and experimental validation.

International immunopharmacology Feb 21, 2025
Ulcerative colitis (UC) is a heterogeneous autoimmune condition. PANoptosis, a new form of programmed cell death, plays a role in inflammatory diseases. This study aimed to identify differentially expressed PANoptosis-related genes (PRGs) involved in...
Gene Regulatory Networks Humans Mice Machine Learning Computational Biology Disease Models, Animal Biomarkers Colitis, Ulcerative Animals
View on PubMed DOI

Integrating manual preprocessing with automated feature extraction for improved rodent seizure classification.

Epilepsy & behavior : E&B Feb 20, 2025
HYPOTHESIS/OBJECTIVE: Rodent models of epilepsy can help with the search for more effective drug candidates or neuromodulatory therapies. Yet, preclinical screening of candidate options for anti-epileptic drugs (AED) using rodent models may require h...
Video Recording Rats Disease Models, Animal Seizures Animals Male Deep Learning
View on PubMed DOI

ML-AMPs designed through machine learning show antifungal activity against C. albicans and therapeutic potential on mice model with candidiasis.

Life sciences Feb 19, 2025
AIMS: C. albicans resistant strains have led to increasingly severe treatment challenges. Antimicrobial peptides with low resistance-inducing propensity for pathogens have been developed. A series of antimicrobial peptides de novo designed through ma...
Candidiasis Antifungal Agents Drug Resistance, Fungal Antimicrobial Peptides Mice Candida albicans Disease Models, Animal Mice, Inbred BALB C Animals Biofilms Microbial Sensitivity Tests Machine Learning Female
View on PubMed DOI

Key RNA-binding proteins in renal fibrosis: a comprehensive bioinformatics and machine learning framework for diagnostic and therapeutic insights.

Renal failure Feb 16, 2025
BACKGROUND: Renal fibrosis is a critical factor in chronic kidney disease progression, with limited diagnostic and therapeutic options. Emerging evidence suggests RNA-binding proteins (RBPs) are pivotal in regulating cellular mechanisms underlying fi...
Humans Machine Learning Biomarkers Computational Biology RNA-Binding Proteins Kidney Renal Insufficiency, Chronic Animals Single-Cell Analysis Mice Disease Models, Animal Fibrosis Ureteral Obstruction
View on PubMed DOI
Popular Topics
Recent Journals