AIMC Topic: Disease Progression

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Profiling short-term longitudinal severity progression and associated genes in COVID-19 patients using EHR and single-cell analysis.

Scientific reports
Here we propose CovSF, a deep learning model designed to track and forecast short-term severity progression of COVID-19 patients using longitudinal clinical records. The motivation stems from the need for timely medical resource allocation, improved ...

Regulatory T cells and matrix-producing cancer associated fibroblasts contribute on the immune resistance and progression of prognosis related tumor subtypes in ccRCC.

Scientific reports
Clear cell renal cell carcinoma (ccRCC) is a prevalent malignant tumor in the field of urology. The effect of cell heterogeneity on the prognosis and reaction to treatment of ccRCC in large populations is still unclear. By analyzing public single cel...

The Cost-Effectiveness of an Artificial Intelligence-Based Population-Wide Screening Program for Primary Open-Angle Glaucoma in The Netherlands.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
OBJECTIVES: Population-wide screening for primary open-angle glaucoma (glaucoma) is typically not cost-effective because of low prevalence and high costs. We evaluated the cost-effectiveness of repeated artificial intelligence (AI)-based glaucoma scr...

Unraveling the role of perineural invasion in cancer progression across multiple tumor types.

Medical oncology (Northwood, London, England)
Perineural invasion (PNI) refers to the infiltration of tumor cells into the connective tissue of nerves and is increasingly recognized as a pathological hallmark of multiple cancers, including pancreatic, prostate, colorectal, breast, and head and n...

Epicardial adipose tissue, myocardial remodelling and adverse outcomes in asymptomatic aortic stenosis: a post hoc analysis of a randomised controlled trial.

Heart (British Cardiac Society)
BACKGROUND: Epicardial adipose tissue represents a metabolically active visceral fat depot that is in direct contact with the left ventricular myocardium. While it is associated with coronary artery disease, little is known regarding its role in aort...

Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population.

PloS one
BACKGROUND: Atypical Parkinsonian Syndromes (APS) form the third largest group of neurodegenerative disorders including Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), and Corticobasal Syndrome (CBS). These conditions are charact...

Your turn: At home turning angle estimation for Parkinson's disease severity assessment.

Artificial intelligence in medicine
People with Parkinson's Disease (PD) often experience progressively worsening gait, including changes in how they turn around, as the disease progresses. Existing clinical rating tools are not capable of capturing hour-by-hour variations of PD sympto...

Multi-omics reveals the polyethylene terephthalate carcinogenicity: Cancer progression and immune microenvironment.

Ecotoxicology and environmental safety
Polyethylene terephthalate (PET), a polymer widely used in consumer products, has recently been implicated in cancer progression, though its mechanistic underpinnings remain elusive. This multidisciplinary study systematically investigates PET's carc...

A novel predictive model and therapeutic potential of quercetin derivatives in chronic kidney disease progression.

Biochemical pharmacology
Chronic kidney disease (CKD) remains a pressing global health issue with limited therapeutic options. The loss of nephrons is a crucial pathological change driving CKD progression, influenced by diverse programmed cell death (PCD) pathways, yet the p...

A machine-learning-based approach to predict early hallmarks of progressive hearing loss.

Hearing research
Machine learning (ML) techniques are increasingly being used to improve disease diagnosis and treatment. However, the application of these computational approaches to the early diagnosis of age-related hearing loss (ARHL), the most common sensory def...