AIMC Topic: DNA Damage
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Sperm quality of rats exposed to difenoconazole using classical parameters and surface-enhanced Raman scattering: classification performance by machine learning methods.
Environmental science and pollution research international
Nov 7, 2019
Difenoconazole is a fungicide extensively used in agriculture. The aim of this study was to evaluate the effects of difenoconazole fungicide on the sperm quality of rats. Wistar rats were divided into four groups: control and exposed to 5 (D5), 10 (D...
Classification of DNA damages on segmented comet assay images using convolutional neural network.
Computer methods and programs in biomedicine
Nov 6, 2019
BACKGROUND AND OBJECTIVE: Identification and quantification of DNA damage is a very significant subject in biomedical research area which still needs more robust and effective methods. One of the cheapest, easy to use and most successful method for D...
Evaluating genotoxicity of metal oxide nanoparticles: Application of advanced supervised and unsupervised machine learning techniques.
Ecotoxicology and environmental safety
Sep 30, 2019
Presence of missing data points in datasets is among main challenges in handling the toxicological data for nanomaterials. As the processing of missing data is an important part of data analysis, we have introduced a read-across approach that uses a ...
Dry olive leaf extract attenuates DNA damage induced by estradiol and diethylstilbestrol in human peripheral blood cells in vitro.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 21, 2018
Phenolic groups of steroidal or nonsteroidal estrogens can redox cycle, leading to oxidative stress, where creation of reactive oxygen species are recognized as the main mechanism of their DNA damage properties. Dry olive (Olea europaea L.) leaf extr...
Free Radical Scavengers
Plant Extracts
Dose-Response Relationship, Drug
Reactive Oxygen Species
Blood Cells
Male
Oxidation-Reduction
Plant Leaves
Humans
Comet Assay
Oxidative Stress
DNA Damage
Female
Estradiol
Diethylstilbestrol
Drug Evaluation, Preclinical
Young Adult
Antioxidants
Estrogen Antagonists
Olea
Adult
Manganese oxide nanoparticles induce genotoxicity and DNA hypomethylation in the moss Physcomitrella patens.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 18, 2018
The genotoxicity of nanoparticles is a major concern for nano-safety appraisal in the bryophytes as they are the primary colonizers of bare land, indicators of atmospheric pollution and excellent accumulators of trace metals. The present study for th...
Genotoxicity evaluation of titanium dioxide nanoparticles using the mouse lymphoma assay and the Ames test.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 1, 2018
Titanium dioxide nanoparticles (TiO-NPs) are widely used in the cosmetics, health, and food industries, but their safety and genotoxicity remain a matter of debate. We investigated whether TiO-NPs could induce gene mutations in mouse lymphoma L5178Y ...
Biosynthesis of copper nanoparticles using Shewanella loihica PV-4 with antibacterial activity: Novel approach and mechanisms investigation.
Journal of hazardous materials
Dec 29, 2017
Metallic nanoparticle based disinfection represents a promising approach for microbial pollution control in drinking water and thus, biosynthesis of non precious metal nanoparticles is of considerable interest. Herein, an original and efficient route...
Investigation of genotoxic effects of paraben in cultured human lymphocytes.
Drug and chemical toxicology
Dec 27, 2017
Paraben is a phenolic derivative of benzoic acid extensively used as preservatives in food, pharmaceutical, and cosmetic industries due to its antimicrobial characteristics. The objective of this study was to evaluate the in vitro genotoxic effects o...
From word models to executable models of signaling networks using automated assembly.
Molecular systems biology
Nov 24, 2017
Word models (natural language descriptions of molecular mechanisms) are a common currency in spoken and written communication in biomedicine but are of limited use in predicting the behavior of complex biological networks. We present an approach to b...
Natural Language Processing
DNA Damage
Sulfonamides
Indoles
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Models, Genetic
Signal Transduction
Proto-Oncogene Proteins B-raf
Vemurafenib
Enzyme Inhibitors
Drug Resistance, Neoplasm
Tumor Suppressor Protein p53
Proto-Oncogene Proteins p21(ras)
Humans
Neural Networks, Computer
Computer Simulation
Language
Melanoma
Skin Neoplasms
Antineoplastic Agents
Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles.
Journal of environmental sciences (China)
Nov 7, 2017
As well-known persistent organic pollutants (POPs), organofluorine pollutants such as perfluorooctane sulfonate (PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, ...
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