AIMC Topic: DNA Damage

Clear Filters Showing 21 to 30 of 45 articles

Evaluating genotoxicity of metal oxide nanoparticles: Application of advanced supervised and unsupervised machine learning techniques.

Ecotoxicology and environmental safety Sep 30, 2019
Presence of missing data points in datasets is among main challenges in handling the toxicological data for nanomaterials. As the processing of missing data is an important part of data analysis, we have introduced a read-across approach that uses a ...
Humans Models, Theoretical Oxides DNA Damage Comet Assay Mutagens Quantitative Structure-Activity Relationship Cell Line Salmonella typhimurium Unsupervised Machine Learning Metal Nanoparticles
View on PubMed DOI

Dry olive leaf extract attenuates DNA damage induced by estradiol and diethylstilbestrol in human peripheral blood cells in vitro.

Mutation research. Genetic toxicology and environmental mutagenesis Dec 21, 2018
Phenolic groups of steroidal or nonsteroidal estrogens can redox cycle, leading to oxidative stress, where creation of reactive oxygen species are recognized as the main mechanism of their DNA damage properties. Dry olive (Olea europaea L.) leaf extr...
Free Radical Scavengers Blood Cells Comet Assay Diethylstilbestrol Plant Extracts Male Humans Dose-Response Relationship, Drug Estrogen Antagonists Oxidative Stress Oxidation-Reduction Reactive Oxygen Species Female Estradiol Plant Leaves Young Adult Antioxidants DNA Damage Adult Drug Evaluation, Preclinical Olea
View on PubMed DOI

Manganese oxide nanoparticles induce genotoxicity and DNA hypomethylation in the moss Physcomitrella patens.

Mutation research. Genetic toxicology and environmental mutagenesis Dec 18, 2018
The genotoxicity of nanoparticles is a major concern for nano-safety appraisal in the bryophytes as they are the primary colonizers of bare land, indicators of atmospheric pollution and excellent accumulators of trace metals. The present study for th...
Hydrogen Peroxide Nanoparticles DNA Methylation Bryopsida Manganese Compounds Mutagens Oxides DNA Damage Comet Assay
View on PubMed DOI

Genotoxicity evaluation of titanium dioxide nanoparticles using the mouse lymphoma assay and the Ames test.

Mutation research. Genetic toxicology and environmental mutagenesis Dec 1, 2018
Titanium dioxide nanoparticles (TiO-NPs) are widely used in the cosmetics, health, and food industries, but their safety and genotoxicity remain a matter of debate. We investigated whether TiO-NPs could induce gene mutations in mouse lymphoma L5178Y ...
Animals Cell Line, Tumor Mutagenesis Mice Salmonella typhimurium Mutagenicity Tests Metal Nanoparticles Mutation Rate DNA Damage Titanium
View on PubMed DOI

Biosynthesis of copper nanoparticles using Shewanella loihica PV-4 with antibacterial activity: Novel approach and mechanisms investigation.

Journal of hazardous materials Dec 29, 2017
Metallic nanoparticle based disinfection represents a promising approach for microbial pollution control in drinking water and thus, biosynthesis of non precious metal nanoparticles is of considerable interest. Herein, an original and efficient route...
Lipid Peroxidation Cell Membrane Shewanella Metal Nanoparticles Disinfection DNA Damage Water Purification Copper Escherichia coli Reactive Oxygen Species
View on PubMed DOI

Investigation of genotoxic effects of paraben in cultured human lymphocytes.

Drug and chemical toxicology Dec 27, 2017
Paraben is a phenolic derivative of benzoic acid extensively used as preservatives in food, pharmaceutical, and cosmetic industries due to its antimicrobial characteristics. The objective of this study was to evaluate the in vitro genotoxic effects o...
Humans Chromosome Aberrations Micronuclei, Chromosome-Defective DNA Damage Mitotic Index Lymphocytes Sister Chromatid Exchange Cells, Cultured Healthy Volunteers Parabens Dose-Response Relationship, Drug Comet Assay Mutagens Micronucleus Tests
View on PubMed DOI

From word models to executable models of signaling networks using automated assembly.

Molecular systems biology Nov 24, 2017
Word models (natural language descriptions of molecular mechanisms) are a common currency in spoken and written communication in biomedicine but are of limited use in predicting the behavior of complex biological networks. We present an approach to b...
Proto-Oncogene Proteins B-raf Vemurafenib Enzyme Inhibitors Computer Simulation Humans DNA Damage Signal Transduction Drug Resistance, Neoplasm Neural Networks, Computer Language Natural Language Processing Sulfonamides Tumor Suppressor Protein p53 Antineoplastic Agents Indoles Proto-Oncogene Proteins p21(ras) Cell Line, Tumor Gene Expression Regulation, Neoplastic Models, Genetic Melanoma Skin Neoplasms
View on PubMed DOI

Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles.

Journal of environmental sciences (China) Nov 7, 2017
As well-known persistent organic pollutants (POPs), organofluorine pollutants such as perfluorooctane sulfonate (PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, ...
Reactive Oxygen Species Cell Survival Metal Nanoparticles DNA Damage Fluorocarbons Toxicity Tests Fluorocarbon Polymers Cell Death Alkanesulfonic Acids Nanoparticles Polymethyl Methacrylate
View on PubMed DOI

Evaluation of genotoxic effects in Brazilian agricultural workers exposed to pesticides and cigarette smoke using machine-learning algorithms.

Environmental science and pollution research international Oct 30, 2017
Monitoring exposure to xenobiotics by biomarker analyses, such as a micronucleus assay, is extremely important for the precocious detection and prevention of diseases, such as oral cancer. The aim of this study was to evaluate genotoxic effects in ru...
Humans Machine Learning Brazil Occupational Exposure DNA Damage Pesticides Smoking Female Young Adult Adult Male Mutagens Farmers
View on PubMed DOI

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach.

Environmental and molecular mutagenesis Jan 13, 2016
Several endpoints associated with cellular responses to DNA damage as well as overt cytotoxicity were multiplexed into a miniaturized, "add and read" type flow cytometric assay. Reagents included a detergent to liberate nuclei, RNase and propidium io...
Histones Aneugens Flow Cytometry Tumor Suppressor Protein p53 Mutagens Mutagenicity Tests Humans Machine Learning Algorithms Automation, Laboratory Biomarkers Reproducibility of Results Cell Line DNA Damage
View on PubMed DOI
Popular Topics
Recent Journals