AIMC Topic: DNA Methylation
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The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer.
Genome medicine
Dec 22, 2017
BACKGROUND: Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant methylation patterns of linked CpGs analyzed in DNA fragments shed by cancer...
Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC).
Clinical epigenetics
Dec 15, 2017
BACKGROUND: DNA methylation has been implicated as a promising biomarker for precise cancer diagnosis. However, limited DNA methylation-based biomarkers have been described in esophageal squamous cell carcinoma (ESCC).
Epigenesis, Genetic
Databases, Genetic
Sequence Analysis, DNA
DNA Methylation
DNA-Binding Proteins
Esophageal Neoplasms
CpG Islands
Early Detection of Cancer
Protein Serine-Threonine Kinases
Biomarkers, Tumor
Male
Middle Aged
Logistic Models
Female
Humans
Carcinoma, Squamous Cell
Serine-Threonine Kinase 3
Machine Learning
Aged
Promoter Regions, Genetic
Sensitivity and Specificity
Esophageal Squamous Cell Carcinoma
Pseudogenes
Repressor Proteins
Commercial glucometer as signal transducer for simple evaluation of DNA methyltransferase activity and inhibitors screening.
Analytica chimica acta
Nov 23, 2017
DNA methyltransferase (MTase) plays an important role in many biological processes and has been recognized as a predictive cancer biomarker far before other signs of malignancy and a therapeutic target in cancer treatment. Thus simple and sensitive d...
Multi-label Inductive Matrix Completion for Joint MGMT and IDH1 Status Prediction for Glioma Patients.
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Sep 4, 2017
MGMT promoter methylation and IDH1 mutation in high-grade gliomas (HGG) have proven to be the two important molecular indicators associated with better prognosis. Traditionally, the statuses of MGMT and IDH1 are obtained via surgical biopsy, which is...
Artificial Intelligence, DNA Mimicry, and Human Health.
Medical science monitor : international medical journal of experimental and clinical research
Aug 14, 2017
The molecular evolution of genomic DNA across diverse plant and animal phyla involved dynamic registrations of sequence modifications to maintain existential homeostasis to increasingly complex patterns of environmental stressors. As an essential cor...
DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing.
Forensic science international. Genetics
Feb 28, 2017
The ability to estimate the age of the donor from recovered biological material at a crime scene can be of substantial value in forensic investigations. Aging can be complex and is associated with various molecular modifications in cells that accumul...
Learning MRI-based classification models for MGMT methylation status prediction in glioblastoma.
Computer methods and programs in biomedicine
Dec 30, 2016
BACKGROUND AND OBJECTIVE: The O-methylguanine-DNA-methyltransferase (MGMT) promoter methylation has been shown to be associated with improved outcomes in patients with glioblastoma (GBM) and may be a predictive marker of sensitivity to chemotherapy. ...
Sensitive detection of DNA methyltransferase using the dendritic rolling circle amplification-induced fluorescence.
Analytica chimica acta
Dec 27, 2016
The analysis of DNA methylation and MTase activities is very important in the early clinical diagnosis of cancer, on purposes of providing insights into the mechanism of gene repression and developing novel drugs of treating methylation-related disea...
The method for breast cancer grade prediction and pathway analysis based on improved multiple kernel learning.
Journal of bioinformatics and computational biology
Nov 29, 2016
Breast cancer histologic grade represents the morphological assessment of the tumor's malignancy and aggressiveness, which is vital in clinically planning treatment and estimating prognosis for patients. Therefore, the prediction of breast cancer gra...
Comprehensive analysis of epigenetically regulated genes in anergic T cells.
Cellular immunology
Nov 2, 2016
T cell anergy is one of the important mechanisms for immune tolerance. The results of many studies investigating the mechanism for T cell anergy induction have revealed that the expression of several genes was up-regulated in anergic T cells. It has ...
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