AIMC Topic: Drug Monitoring
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Probing the characteristics and biofunctional effects of disease-affected cells and drug response via machine learning applications.
Critical reviews in biotechnology
Jul 7, 2020
Drug-induced transformations in disease characteristics at the cellular and molecular level offers the opportunity to predict and evaluate the efficacy of pharmaceutical ingredients whilst enabling the optimal design of new and improved drugs with en...
A semi-automated machine-learning based workflow for ellipsoid zone analysis in eyes with macular edema: SCORE2 pilot study.
PloS one
Apr 30, 2020
BACKGROUND AND OBJECTIVE: To develop a semi-automated, machine-learning based workflow to evaluate the ellipsoid zone (EZ) assessed by spectral domain optical coherence tomography (SD-OCT) in eyes with macular edema secondary to central retinal or he...
Humans
Machine Learning
Receptors, Vascular Endothelial Growth Factor
Bevacizumab
Retinal Vein Occlusion
Treatment Outcome
Tomography, Optical Coherence
Middle Aged
Macular Edema
Drug Monitoring
Female
Pilot Projects
Adult
Workflow
Vascular Endothelial Growth Factor A
Image Processing, Computer-Assisted
Recombinant Fusion Proteins
Male
Angiogenesis Inhibitors
Macula Lutea
Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock - rationale and design of a multicenter randomized controlled superiority trial.
Trials
Dec 18, 2019
BACKGROUND: Antibiotic exposure is often inadequate in critically ill patients with severe sepsis or septic shock and this is associated with worse outcomes. Despite markedly altered and rapidly changing pharmacokinetics in these patients, guidelines...
Big Data
Shock, Septic
Treatment Outcome
Dose-Response Relationship, Drug
Adult
Male
Severity of Illness Index
Kaplan-Meier Estimate
Equivalence Trials as Topic
Multicenter Studies as Topic
Randomized Controlled Trials as Topic
Drug Monitoring
Netherlands
Humans
Artificial Intelligence
Research Design
Anti-Bacterial Agents
Intensive Care Units
Female
Initial dosing of intermittent vancomycin in adults: estimation of dosing interval in relation to dose and renal function.
European journal of hospital pharmacy : science and practice
Aug 7, 2019
OBJECTIVES: Due to the high interindividual variability in vancomycin pharmacokinetics, optimisation of its dosing is still challenging. This study aimed to explore vancomycin pharmacokinetics in adult patients and to propose an easy applicable dosin...
Prediction of Chemotherapy Response of Osteosarcoma Using Baseline F-FDG Textural Features Machine Learning Approaches with PCA.
Contrast media & molecular imaging
Jul 24, 2019
PURPOSE: Patients with high-grade osteosarcoma undergo several chemotherapy cycles before surgical intervention. Response to chemotherapy, however, is affected by intratumor heterogeneity. In this study, we assessed the ability of a machine learning ...
UHPLC-MS/MS method for simultaneous determination of carbamazepine and its seven major metabolites in serum of epileptic patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 14, 2018
Carbamazepine (CBZ) was considered as the drug of choice in the treatment for various forms of epilepsy, yet the non-negligible adverse effects of CBZ suspend as the major concern for rational and efficient clinical medication. This study developed a...
A 6 Second Analytical Method for Quantitation of Tacrolimus in Whole Blood by Use of Laser Diode Thermal Desorption Tandem Mass Spectrometry.
The journal of applied laboratory medicine
Dec 7, 2018
BACKGROUND: Therapeutic drug monitoring of immunosuppressive drugs is imperative for organ transplant recipients. High-performance LC-MS/MS is considered gold standard; however, immunoassays provide rapid turnaround time. New technology was developed...
Validation of the Behavior of a Knowledge Base Implementing Clinical Guidelines for Point-of-Care Antiretroviral Toxicity Monitoring.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
This study investigated the automated detection of antiretroviral toxicities in structured electronic health records data. The evaluation compared responses generated by 5 clinical pharmacists and 1 prototype knowledge-based application for 15 random...
Therapeutic drug monitoring of levetiracetam in daily clinical practice: high-performance liquid chromatography versus immunoassay.
European journal of hospital pharmacy : science and practice
Oct 20, 2018
OBJECTIVES: Although levetiracetam presents an easy dosing and tolerability, therapeutic drug monitoring may be recommended in certain situations. Measurement of levetiracetam in serum plasma is commonly done by high performance liquid chromatography...
Fast and easy extraction of antidepressants from whole blood using ionic liquids as extraction solvent.
Talanta
Dec 16, 2017
This study aims to prove that ionic liquids (ILs) can be used as extraction solvents in a liquid-liquid microextraction, coupled to LC-MS/MS, for the quantification of a large group of antidepressants in whole blood samples. The sample preparation pr...
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