AIMC Topic: Epigenesis, Genetic
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Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease.
Cardiovascular diabetology
Jun 23, 2025
BACKGROUND: Coronary angiography remains the gold standard for diagnosing coronary artery disease (CAD), but its invasive nature limits its applicability for widespread screening. Identifying non-invasive molecular markers could improve CAD classific...
Risk Assessment
Severity of Illness Index
Epigenesis, Genetic
Inflammation
Aged
Male
Middle Aged
ST Elevation Myocardial Infarction
Coronary Artery Disease
Inflammation Mediators
5-Methylcytosine
Humans
DNA Methylation
Cell-Free Nucleic Acids
Machine Learning
Non-ST Elevated Myocardial Infarction
Biomarkers
Predictive Value of Tests
Prognosis
Female
Reproducibility of Results
Artificial Intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine.
Epigenetics & chromatin
Jun 14, 2025
DNA methylation is a fundamental epigenetic modification that regulates gene expression and maintains genomic stability. Consequently, DNA methylation remains a key biomarker in cancer research, playing a vital role in diagnosis, prognosis, and tailo...
Integrative analysis of epigenetic and transcriptional interrelations identifies histotype-specific biomarkers in early-stage ovarian carcinoma.
Journal of ovarian research
May 19, 2025
BACKGROUND: Epithelial ovarian cancer (EOC) is a deadly and heterogenous disease comprising five major histotypes: clear cell carcinoma (CCC), endometrioid carcinoma (EC), low- and high-grade serous carcinoma (LGSC, HGSC), and mucinous carcinoma (MC)...
Artificial intelligence-driven genotype-epigenotype-phenotype approaches to resolve challenges in syndrome diagnostics.
EBioMedicine
Apr 24, 2025
BACKGROUND: Decisions to split two or more phenotypic manifestations related to genetic variations within the same gene can be challenging, especially during the early stages of syndrome discovery. Genotype-based diagnostics with artificial intellige...
Pathogenomic fingerprinting to identify associations between tumor morphology and epigenetic states.
European journal of cancer (Oxford, England : 1990)
Apr 14, 2025
INTRODUCTION: Measuring the chromatin state of a tumor provides a powerful map of its epigenetic commitments; however, as these are generally bulk measurements, it has not yet been possible to connect changes in chromatin accessibility to the patholo...
Genome-wide methylome modeling via generative AI incorporating long- and short-range interactions.
Science advances
Apr 11, 2025
Using millions of methylation segments, we developed DiffuCpG, a generative artificial intelligence (AI) diffusion model designed to solve the critical challenge of missing data in high-throughput methylation technologies. DiffuCpG goes beyond conven...
DeepMethyGene: a deep-learning model to predict gene expression using DNA methylations.
BMC bioinformatics
Apr 8, 2025
Gene expression is the basis for cells to achieve various functions, while DNA methylation constitutes a critical epigenetic mechanism governing gene expression regulation. Here we propose DeepMethyGene, an adaptive recursive convolutional neural net...
The relationship between epigenetic biomarkers and the risk of diabetes and cancer: a machine learning modeling approach.
Frontiers in public health
Mar 21, 2025
INTRODUCTION: Epigenetic biomarkers are molecular indicators of epigenetic changes, and some studies have suggested that these biomarkers have predictive power for disease risk. This study aims to analyze the relationship between 30 epigenetic biomar...
Spatial recognition and semi-quantification of epigenetic events in pancreatic cancer subtypes with multiplexed molecular imaging and machine learning.
Scientific reports
Feb 22, 2025
Genomic alterations are the driving force behind pancreatic cancer (PC) tumorigenesis, but they do not fully account for its diverse phenotypes. Investigating the epigenetic landscapes of PC offers a more comprehensive understanding and could identif...
Deep learning imputes DNA methylation states in single cells and enhances the detection of epigenetic alterations in schizophrenia.
Cell genomics
Feb 21, 2025
DNA methylation (DNAm) is a key epigenetic mark with essential roles in gene regulation, mammalian development, and human diseases. Single-cell technologies enable profiling DNAm at cytosines in individual cells, but they often suffer from low covera...
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