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Prioritizing and characterizing functionally relevant genes across human tissues.

PLoS computational biology
Knowledge of genes that are critical to a tissue's function remains difficult to ascertain and presents a major bottleneck toward a mechanistic understanding of genotype-phenotype links. Here, we present the first machine learning model-FUGUE-combini...

The neural representation of abstract words may arise through grounding word meaning in language itself.

Human brain mapping
In order to describe how humans represent meaning in the brain, one must be able to account for not just concrete words but, critically, also abstract words, which lack a physical referent. Hebbian formalism and optimization are basic principles of b...

Deep neural network for automatic volumetric segmentation of whole-body CT images for body composition assessment.

Clinical nutrition (Edinburgh, Scotland)
BACKGROUND & AIMS: Body composition analysis on CT images is a valuable tool for sarcopenia assessment. We aimed to develop and validate a deep neural network applicable to whole-body CT images of PET-CT scan for the automatic volumetric segmentation...

Systems biology informed neural networks (SBINN) predict response and novel combinations for PD-1 checkpoint blockade.

Communications biology
Anti-PD-1 immunotherapy has recently shown tremendous success for the treatment of several aggressive cancers. However, variability and unpredictability in treatment outcome have been observed, and are thought to be driven by patient-specific biology...

A fuzzy rank-based ensemble of CNN models for classification of cervical cytology.

Scientific reports
Cervical cancer affects more than 0.5 million women annually causing more than 0.3 million deaths. Detection of cancer in its early stages is of prime importance for eradicating the disease from the patient's body. However, regular population-wise sc...

Prediction of well-being and insight into work-life integration among physicians using machine learning approach.

PloS one
There has been increasing interest in examining physician well-being and its predictive factors. However, few studies have revealed the characteristics associated with physician well-being and work-life integration using a machine learning approach. ...

Development of MRI-Based Radiomics Model to Predict the Risk of Recurrence in Patients With Advanced High-Grade Serous Ovarian Carcinoma.

AJR. American journal of roentgenology
The purpose of our study was to develop a radiomics model based on preoperative MRI and clinical information for predicting recurrence-free survival (RFS) in patients with advanced high-grade serous ovarian carcinoma (HGSOC). This retrospective stu...

Predicting survival in heart failure: a risk score based on machine-learning and change point algorithm.

Clinical research in cardiology : official journal of the German Cardiac Society
OBJECTIVE: Machine learning (ML) algorithm can improve risk prediction because ML can select features and segment continuous variables effectively unbiased. We generated a risk score model for mortality with ML algorithms in East-Asian patients with ...

Combining Genetic Algorithms and SVM for Breast Cancer Diagnosis Using Infrared Thermography.

Sensors (Basel, Switzerland)
Breast cancer is one of the leading causes of mortality globally, but early diagnosis and treatment can increase the cancer survival rate. In this context, thermography is a suitable approach to help early diagnosis due to the temperature difference ...

Automatic segmentation of uterine endometrial cancer on multi-sequence MRI using a convolutional neural network.

Scientific reports
Endometrial cancer (EC) is the most common gynecological tumor in developed countries, and preoperative risk stratification is essential for personalized medicine. There have been several radiomics studies for noninvasive risk stratification of EC us...