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The Role of PANoptosis-Related Genes in Predicting Breast Cancer Survival and Immune Prospect.
BioMed research international
May 28, 2025
The function of PANoptosis in breast cancer (BC) remains indistinct. We constructed a nomogram model to predict the prognosis of BC to identify high-risk patients and help them receive more accurate treatment. We used Cox regression and least absol...
Advanced predictive modeling for enhanced mortality prediction in ICU stroke patients using clinical data.
PloS one
May 28, 2025
Background Stroke is second-leading cause of disability and death among adults. Approximately 17 million people suffer from a stroke annually, with about 85% being ischemic strokes. Predicting mortality of ischemic stroke patients in intensive care u...
The risk factors for relapse behavior in individuals with substance use disorders: An interpretable machine learning study.
Journal of affective disorders
May 27, 2025
BACKGROUND: Substance abuse has become a serious public health problem worldwide, and finding effective prevention and treatment strategies is undoubtedly an urgent need. This study addresses the risk factors that lead to relapse behaviors among subs...
Hemoglobin - to - red cell distribution width ratio in depression symptoms: Threshold effects and metabolic - inflammatory mediation revealed by multimodal machine learning and symptom network analysis in 196,260 adults.
Journal of affective disorders
May 27, 2025
OBJECTIVE: To investigate the association between hemoglobin to red blood cell distribution width ratio (HRR) and depression symptoms.
Machine learning models of depression in middle-aged and older adults with cardiovascular metabolic diseases.
Journal of affective disorders
May 27, 2025
BACKGROUND: The incidence of cardiovascular metabolic diseases (CMD) is increasing, and depression in CMD patients significantly impacts prognosis. Therefore, this study aimed to develop and validate a predictive model for depression in CMD patients ...
Functional connectome-based predictive modeling of suicidal ideation.
Journal of affective disorders
May 27, 2025
Suicide represents an egregious threat to society despite major advancements in medicine, in part due to limited knowledge of the biological mechanisms of suicidal behavior. We apply a connectome predictive modeling machine learning approach to ident...
Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy.
EBioMedicine
May 27, 2025
BACKGROUND: The impact of high body mass index (BMI) states and associated proteomic factors on brain ageing and Alzheimer's disease (AD) remains unclear.
Automatic identification of Parkinsonism using clinical multi-contrast brain MRI: a large self-supervised vision foundation model strategy.
EBioMedicine
May 27, 2025
BACKGROUND: Valid non-invasive biomarkers for Parkinson's disease (PD) and Parkinson-plus syndrome (PPS) are urgently needed. Based on our recent self-supervised vision foundation model the Shift Window UNET TRansformer (Swin UNETR), which uses clini...
Mechanisms and management of self-resolving lumbar disc herniation: bridging molecular pathways to non-surgical clinical success.
Journal of orthopaedic surgery and research
May 27, 2025
Spontaneous resorption of lumbar disk herniation (LDH) presents a promising avenue for the non-surgical management of herniated disks. Here we present a 40-year-old female with severe L5/S1 herniation who experienced spontaneous resorption confirmed ...
Rapid diagnosis of TERT promoter mutation using Terahertz absorption spectroscopy in glioblastoma.
Scientific reports
May 27, 2025
Glioblastoma (GBM) is a highly aggressive brain tumor with poor outcomes and limited treatment options. The telomerase reverse transcriptase (TERT) promoter mutation, one of the key biomarkers in GBM, is linked to tumor progression and prognosis. Thi...
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